Diffuse vertebral body metastasis from a glioblastoma multiforme: a technetium-99m Sestamibi single-photon emission computerized tomography study

Case report

Patrick Beauchesne Services de Neurochirurgie, Médecine Nucléaire, et Anatomie Pathologique, Hôpital de Bellevue, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France

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 M.D.
,
Claude Soler Services de Neurochirurgie, Médecine Nucléaire, et Anatomie Pathologique, Hôpital de Bellevue, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France

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 M.D.
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Jean-François Mosnier Services de Neurochirurgie, Médecine Nucléaire, et Anatomie Pathologique, Hôpital de Bellevue, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France

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 M.D.
Page Range:
887–890
Volume/Issue:
Volume 93: Issue 5
DOI link:
https://doi.org/10.3171/jns.2000.93.5.0887
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✓ The authors report on a case of right temporal glioblastoma multiforme (GBM) that metastasized to multiple bone regions (dorsolumbar vertebrae and iliac bone) 8 months after initial diagnosis, despite combined radio- and chemotherapy. Results of a whole-bone single-photon emission computerized tomography (SPECT) study using the imaging agent Sestamibi (MIBI) revealed extracranial metastases from the GBM. A magnetic resonance imaging study of the dorsolumbar spinal region completed the radiological investigation. Cells immunoreactive to glial fibrillary acidic protein were observed in a specimen obtained from the right iliac bone. Postmortem examination confirmed metastasis to extracranial bone and revealed two other metastatic localizations in the lung and heart. This is the first reported case of extracranial bone metastasis from a GBM demonstrated on a whole-bone MIBI SPECT scan. In patients with malignant glioma and lower-back pain (especially prolonged pain), bone metastasis, although uncommon, does occasionally occur and its possibility should be investigated; a MIBI SPECT study may prove useful in this regard.

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Contributor Notes

Address reprint requests to: Patrick Beauchesne, M.D., Service de Neurochirurgie, Hôpital de Bellevue, Centre Hospitalier Universitaire de Saint-Etienne, 42055 Saint-Etienne Cedex 2, France. email: Patrick.Beauchesne@fr.packardbell.org.
  • 1.

    Bagni B, , Pinna L, & Tamarozzi R, et al: SPET imaging of intracranial tumours with 99Tcm-sestamibi. Nucl Med Commun 16:258–264, 1995 Bagni B, Pinna L, Tamarozzi R, et al: SPET imaging of intracranial tumours with 99Tcm-sestamibi. Nucl Med Commun 16:258–264, 1995

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Baillet G, , Albuquerque L, & Chen Q, et al: Evaluation of single-photon emission tomography imaging of supratentorial brain gliomas with technetium-99m sestamibi. Eur J Nucl Med 21:1061–1066, 1994 Baillet G, Albuquerque L, Chen Q, et al: Evaluation of single-photon emission tomography imaging of supratentorial brain gliomas with technetium-99m sestamibi. Eur J Nucl Med 21:1061–1066, 1994

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Black KL, , Emerick T, & Hoh C: Thallium-201 SPECT and positron emission tomography equal predictors of glioma grade and recurrence. Neurol Res 16:93–96, 1994 Black KL, Emerick T, Hoh C: Thallium-201 SPECT and positron emission tomography equal predictors of glioma grade and recurrence. Neurol Res 16:93–96, 1994

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Black PM: Brain tumors. I. N Engl J Med 21:1471–1476, 1991 Black PM: Brain tumors. I. N Engl J Med 21:1471–1476, 1991

  • 5.

    Black PM: Brain tumors (2). N Engl J Med 324:1555–1564, 1991 Black PM: Brain tumors (2). N Engl J Med 324:1555–1564, 1991

  • 6.

    Chiu ML, , Kronauge JF, & Piwnica-Worms D: Effects of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium (I) in cultured mouse fibroblasts. J. Nucl Med 31:1646–1653, 1990 Chiu ML, Kronauge JF, Piwnica-Worms D: Effects of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium (I) in cultured mouse fibroblasts. J. Nucl Med 31:1646–1653, 1990

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Chretien F, , Gray F, & Funalot B, et al: Métastases extranévraxiques d'un glioblastome, en l'absence de chirurgie. Arch Anat Cytol Pathol 43:342–349, 1995 Chretien F, Gray F, Funalot B, et al: Métastases extranévraxiques d'un glioblastome, en l'absence de chirurgie. Arch Anat Cytol Pathol 43:342–349, 1995

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Daumas-Duport C, , Scheithauer B, & O'Fallon J: Grading of astrocytomas. A simple and reproducible method. Cancer 62:2152–2165, 1988 Daumas-Duport C, Scheithauer B, O'Fallon J: Grading of astrocytomas. A simple and reproducible method. Cancer 62:2152–2165, 1988

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Finsterer J, , Breiteneder S, & Mueller MR, et al: Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. Oncology 55:345–348, 1998 Finsterer J, Breiteneder S, Mueller MR, et al: Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III. Oncology 55:345–348, 1998

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Hoffman HJ, & Duffner PK: Extraneural metastases of central nervous system tumors. Cancer 56 (Suppl):1178–1182, 1985 Hoffman HJ, Duffner PK: Extraneural metastases of central nervous system tumors. Cancer 56 (Suppl):1178–1182, 1985

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Hsu E, , Keene D, & Ventureyra E, et al: Bone marrow metastasis in astrocytic gliomata. J Neurooncol 37:285–293, 1998 Hsu E, Keene D, Ventureyra E, et al: Bone marrow metastasis in astrocytic gliomata. J Neurooncol 37:285–293, 1998

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Kahn D, , Follett KA, & Bushnell DL: Diagnosis of recurrent brain tumor: value of 201Tl SPECT vs 18F-Fluorodeoxyglucose PET. AJR 163:1459–1465, 1994 Kahn D, Follett KA, Bushnell DL: Diagnosis of recurrent brain tumor: value of 201Tl SPECT vs 18F-Fluorodeoxyglucose PET. AJR 163:1459–1465, 1994

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Longee DC, , Friedman HS, & Phillips PC, et al: Osteoblastic metastasis from astrocytomas: a report of two cases. Med Pediatr Oncol 19:318–324, 1991 Longee DC, Friedman HS, Phillips PC, et al: Osteoblastic metastasis from astrocytomas: a report of two cases. Med Pediatr Oncol 19:318–324, 1991

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Maffioli L, , Gasparini M, & Chiti A, et al: Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours. Eur J Nucl Med 23:308–311, 1996 Maffioli L, Gasparini M, Chiti A, et al: Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours. Eur J Nucl Med 23:308–311, 1996

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Malca SA, , Roche PH, & Pellet W: Les localisations secondaires du glioblastome cérébral. Mise au point pathogénique et anatomo-clinique. A propos d'un cas de métastases osseuses multiples révélé par une atteinte vertébrale. Neurochirugie 39:315–321, 1993 Malca SA, Roche PH, Pellet W: Les localisations secondaires du glioblastome cérébral. Mise au point pathogénique et anatomo-clinique. A propos d'un cas de métastases osseuses multiples révélé par une atteinte vertébrale. Neurochirugie 39:315–321, 1993

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Mihara F, , Ikeda M, & Rothman MI, et al: Vertebral body metastasis of glioblastoma multiforme with epidural mass formation. Contrast-enhanced MRI study. Clin Imaging 18:386–389, 1994 Mihara F, Ikeda M, Rothman MI, et al: Vertebral body metastasis of glioblastoma multiforme with epidural mass formation. Contrast-enhanced MRI study. Clin Imaging 18:386–389, 1994

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Pasquier B, , Pasquier D, & N'Golet A, et al: Extraneural metastases of astrocytomas and glioblastomas. Clinicopathological study of two cases and review of literature. Cancer 45:112–125, 1980 Pasquier B, Pasquier D, N'Golet A, et al: Extraneural metastases of astrocytomas and glioblastomas. Clinicopathological study of two cases and review of literature. Cancer 45:112–125, 1980

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Piwnica-Worms D, , Kronauge JF, & Chiu ML: Enhancement by tetraphenylborate of technetium-99m-MIBI uptake kinetics and accumulation in cultured chick myocardial cells. J Nucl Med 32:1992–1999, 1991 Piwnica-Worms D, Kronauge JF, Chiu ML: Enhancement by tetraphenylborate of technetium-99m-MIBI uptake kinetics and accumulation in cultured chick myocardial cells. J Nucl Med 32:1992–1999, 1991

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Schatzki SC, , McIlmoyle G, & Lowis S: Diffuse osteoblastic metastases from an intracranial glioma. AJR 128:321–323, 1977 Schatzki SC, McIlmoyle G, Lowis S: Diffuse osteoblastic metastases from an intracranial glioma. AJR 128:321–323, 1977

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Smith DR, , Hardman JM, & Earle KM: Metastasizing neuroectodermal tumors of the central nervous system J Neurosurg 31:50–58, 1969 Smith DR, Hardman JM, Earle KM: Metastasizing neuroectodermal tumors of the central nervous system J Neurosurg 31:50–58, 1969

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Soler C, , Beauchesne P, & Maatougui K, et al: Technetium-99m sestamibi brain single-photon emission tomography for detection of recurrent gliomas after radiation therapy. Eur J Nucl Med 25:1649–1657, 1998 Soler C, Beauchesne P, Maatougui K, et al: Technetium-99m sestamibi brain single-photon emission tomography for detection of recurrent gliomas after radiation therapy. Eur J Nucl Med 25:1649–1657, 1998

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Soler C, , Perrot JL, & Thiffet O, et al: The role of technetium-99m sestamibi single photon emission tomography in the follow-up of malignant melanoma and the detection of lymph node metastases. Eur J Nucl Med 24:1522–1525, 1997 Soler C, Perrot JL, Thiffet O, et al: The role of technetium-99m sestamibi single photon emission tomography in the follow-up of malignant melanoma and the detection of lymph node metastases. Eur J Nucl Med 24:1522–1525, 1997

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Vural G, , Hagmar B, & Walaas L: Extracranial metastasis of glioblastoma multiforme diagnosed by fine-needle aspiration: a report of two cases and a review of the literature. Diagn Cytopathol 15:60–65, 1996 Vural G, Hagmar B, Walaas L: Extracranial metastasis of glioblastoma multiforme diagnosed by fine-needle aspiration: a report of two cases and a review of the literature. Diagn Cytopathol 15:60–65, 1996

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Yanagawa Y, , Miyazawa T, & Ishihara S, et al: Pontine glioma with osteoblastic skeletal metastases in a child. Surg Neurol 46:481–484, 1996 Yanagawa Y, Miyazawa T, Ishihara S, et al: Pontine glioma with osteoblastic skeletal metastases in a child. Surg Neurol 46:481–484, 1996

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation

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