Proliferation potential and histological features in neurofibromatosis 2-associated and sporadic meningiomas

Restricted access

✓ The authors compared the histological appearance and proliferation potential of 35 meningiomas in patients with neurofibromatosis 2 (NF2) and 30 sporadic meningiomas in age- and gender-matched patients without NF2. The NF2 meningiomas showed more mitotic figures (p < 0.001) and nuclear pleomorphism (p = 0.003) than the sporadic meningiomas; however, the incidence of meningothelial, fibroblastic, and transitional subtypes occurred equally in both groups. The proliferation potential was significantly higher in the 35 meningiomas removed from 23 patients with NF2 than in the 30 sporadic meningiomas removed in the 30 patients without NF2 (mean MIB-1 labeling indices: 2.5 vs. 1.75, p = 0.0147). The higher proliferation potential of the NF2 meningiomas may reflect differences in molecular biology between sporadic and NF2 meningiomas and may be related to an earlier onset, multiplicity, and more aggressive behavior of NF2 tumors.

Article Information

Address reprint requests to: Jussi Antinheimo, M.D., Department of Pathology, University of Helsinki, Haartman Institute, POB 21 (Haartmaninkatu 3), FIN-00014 Helsinki, Finland. email: jussi.antinheimo@helsinki.fi.

© AANS, except where prohibited by US copyright law.

Headings

References

  • 1.

    Aguiar PHTatagiba MSamii Met al: The comparison between the growth fraction of bilateral vestibular schwannomas in neurofibromatosis 2 (NF2) and unilateral vestibular schwannomas using the monoclonal antibody MIB 1. Acta Neurochir 134:40451995Aguiar PH Tatagiba M Samii M et al: The comparison between the growth fraction of bilateral vestibular schwannomas in neurofibromatosis 2 (NF2) and unilateral vestibular schwannomas using the monoclonal antibody MIB 1. Acta Neurochir 134:40–45 1995

    • Search Google Scholar
    • Export Citation
  • 2.

    Antinheimo JHaapasalo HSeppälä Met al: Proliferative potential of sporadic and neurofibromatosis 2-associated schwannomas as studied by MIB-1 (Ki-67) and PCNA labeling. J Neuropathol Exp Neurol 54:7767821995Antinheimo J Haapasalo H Seppälä M et al: Proliferative potential of sporadic and neurofibromatosis 2-associated schwannomas as studied by MIB-1 (Ki-67) and PCNA labeling. J Neuropathol Exp Neurol 54:776–782 1995

    • Search Google Scholar
    • Export Citation
  • 3.

    Bourn DCarter SAEvans DGRet al: A mutation in the neurofibromatosis 2 tumor-suppressor gene, giving rise to widely different clinical phenotypes in two unrelated individuals. Am J Hum Genet 55:69731994Bourn D Carter SA Evans DGR et al: A mutation in the neurofibromatosis 2 tumor-suppressor gene giving rise to widely different clinical phenotypes in two unrelated individuals. Am J Hum Genet 55:69–73 1994

    • Search Google Scholar
    • Export Citation
  • 4.

    Cattoretti GBecker MHGKey G: Monoclonal antibodies against recombinant parts of the Ki -67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168:3573631992Cattoretti G Becker MHG Key G: Monoclonal antibodies against recombinant parts of the Ki -67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168:357–363 1992

    • Search Google Scholar
    • Export Citation
  • 5.

    De Vitis LRTedde AVitelli Fet al: Screening for mutations in the neurofibromatosis type 2 (NF2) gene in sporadic meningiomas. Hum Genet 97:6326371996De Vitis LR Tedde A Vitelli F et al: Screening for mutations in the neurofibromatosis type 2 (NF2) gene in sporadic meningiomas. Hum Genet 97:632–637 1996

    • Search Google Scholar
    • Export Citation
  • 6.

    Deen HG JrScheithauer BWEbersold MJ: Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg 56:3173221982Deen HG Jr Scheithauer BW Ebersold MJ: Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg 56:317–322 1982

    • Search Google Scholar
    • Export Citation
  • 7.

    Evans DGRBlair VStrachan Tet al: Variation of expression of the gene for type 2 neurofibromatosis: absence of a gender effect on vestibular schwannomas, but confirmation of a preponderance of meningiomas in females. J Laryngol Otol 109:8308351995Evans DGR Blair V Strachan T et al: Variation of expression of the gene for type 2 neurofibromatosis: absence of a gender effect on vestibular schwannomas but confirmation of a preponderance of meningiomas in females. J Laryngol Otol 109:830–835 1995

    • Search Google Scholar
    • Export Citation
  • 8.

    Evans DGRHuson SMDonnai D et al: A clinical study of type 2 neurofibromatosis. Q J Med 84:6036181992Evans DGR Huson SM Donnai D et al: A clinical study of type 2 neurofibromatosis. Q J Med 84:603–618 1992

    • Search Google Scholar
    • Export Citation
  • 9.

    Jääskeläinen JHaltia MServo M: Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome. Surg Neurol 25:2332421986Jääskeläinen J Haltia M Servo M: Atypical and anaplastic meningiomas: radiology surgery radiotherapy and outcome. Surg Neurol 25:233–242 1986

    • Search Google Scholar
    • Export Citation
  • 10.

    Jääskeläinen JPaetau APyykkö Iet al: Interface between the facial nerve and large acoustic neurinomas. Immunohistochemical study of the cleavage plane in NF2 and non-NF2 cases. J Neurosurg 80:5415471994Jääskeläinen J Paetau A Pyykkö I et al: Interface between the facial nerve and large acoustic neurinomas. Immunohistochemical study of the cleavage plane in NF2 and non-NF2 cases. J Neurosurg 80:541–547 1994

    • Search Google Scholar
    • Export Citation
  • 11.

    Jellinger KSlowik F: Histological subtypes and prognostic problems in meningiomas. J Neurol 208:2792981975Jellinger K Slowik F: Histological subtypes and prognostic problems in meningiomas. J Neurol 208:279–298 1975

    • Search Google Scholar
    • Export Citation
  • 12.

    Karamitopoulou EPerentes EDiamantis Iet al: Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal antibody on archival material. Acta Neuropathol 87:47541994Karamitopoulou E Perentes E Diamantis I et al: Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal antibody on archival material. Acta Neuropathol 87:47–54 1994

    • Search Google Scholar
    • Export Citation
  • 13.

    Kleihues PBurger PCScheithauer BW: Histological Typing of Tumours of the Central Nervous Systemed 2. New York: Springer-Verlag1993 pp 3342Kleihues P Burger PC Scheithauer BW: Histological Typing of Tumours of the Central Nervous System ed 2. New York: Springer-Verlag 1993 pp 33–42

    • Search Google Scholar
    • Export Citation
  • 14.

    Kolles HNiedermayer ISchmitt Cet al: Triple approach for diagnosis and grading of meningiomas: histology, morphometry of Ki-67/feulgen stainings, and cytogenetics. Acta Neurochir 137:1741811995Kolles H Niedermayer I Schmitt C et al: Triple approach for diagnosis and grading of meningiomas: histology morphometry of Ki-67/feulgen stainings and cytogenetics. Acta Neurochir 137:174–181 1995

    • Search Google Scholar
    • Export Citation
  • 15.

    Lekanne Deprez RHBianchi ABGroen NAet al: Frequent NF2 gene transcript mutations in sporadic meningiomas and vestibular schwannomas. Am J Hum Genet 54:102210291994Lekanne Deprez RH Bianchi AB Groen NA et al: Frequent NF2 gene transcript mutations in sporadic meningiomas and vestibular schwannomas. Am J Hum Genet 54:1022–1029 1994

    • Search Google Scholar
    • Export Citation
  • 16.

    Louis DNRamesh VGusella JF: Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol 5:1631721995Louis DN Ramesh V Gusella JF: Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol 5:163–172 1995

    • Search Google Scholar
    • Export Citation
  • 17.

    Mautner VFLindenau MBaser MEet al: The neuroimaging and clinical spectrum of neurofibromatosis 2. Neurosurgery 38:8808861996Mautner VF Lindenau M Baser ME et al: The neuroimaging and clinical spectrum of neurofibromatosis 2. Neurosurgery 38:880–886 1996

    • Search Google Scholar
    • Export Citation
  • 18.

    Mérel PHoang-Xuan KSanson Met al: Screening for germline mutations in the NF2 gene. Genes Chromosom Cancer 12:1171271995Mérel P Hoang-Xuan K Sanson M et al: Screening for germline mutations in the NF2 gene. Genes Chromosom Cancer 12:117–127 1995

    • Search Google Scholar
    • Export Citation
  • 19.

    Nagashima GAoyagi MWakimoto Het al: Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labeling indices in paraffin-embedded sections of meningiomas. Neurosurgery 37:4784831995Nagashima G Aoyagi M Wakimoto H et al: Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labeling indices in paraffin-embedded sections of meningiomas. Neurosurgery 37:478–483 1995

    • Search Google Scholar
    • Export Citation
  • 20.

    Nakasu SNakajima MMatsumura Ket al: Meningioma: proliferating potential and clinicoradiological features. Neurosurgery 37:104910551995Nakasu S Nakajima M Matsumura K et al: Meningioma: proliferating potential and clinicoradiological features. Neurosurgery 37:1049–1055 1995

    • Search Google Scholar
    • Export Citation
  • 21.

    National Institutes of Health Consensus Development Conference: Neurofibromatosis 1 (Recklinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis). An update. Ann Intern Med 113:39521990National Institutes of Health Consensus Development Conference: Neurofibromatosis 1 (Recklinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis). An update. Ann Intern Med 113:39–52 1990

    • Search Google Scholar
    • Export Citation
  • 22.

    Ng HLau KTse JYMet al: Combined molecular genetic studies of chromosome 22q and the neurofibromatosis type 2 gene in central nervous system tumors. Neurosurgery 37:7647731995Ng H Lau K Tse JYM et al: Combined molecular genetic studies of chromosome 22q and the neurofibromatosis type 2 gene in central nervous system tumors. Neurosurgery 37:764–773 1995

    • Search Google Scholar
    • Export Citation
  • 23.

    Parry DMEldridge RKaiser-Kupfer MIet al: Neurofibromatosis 2 (NF2): clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity. Am J Med Genet 52:4504611994Parry DM Eldridge R Kaiser-Kupfer MI et al: Neurofibromatosis 2 (NF2): clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity. Am J Med Genet 52:450–461 1994

    • Search Google Scholar
    • Export Citation
  • 24.

    Peyrard MFransson IXie YGet al: Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Hum Mol Genet 3:139313991994Peyrard M Fransson I Xie YG et al: Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12 a candidate meningioma gene. Hum Mol Genet 3:1393–1399 1994

    • Search Google Scholar
    • Export Citation
  • 25.

    Rohringer MSutherland GRLouw DFet al: Incidence and clinicopathological features of meningioma. J Neurosurg 71:6656721989Rohringer M Sutherland GR Louw DF et al: Incidence and clinicopathological features of meningioma. J Neurosurg 71:665–672 1989

    • Search Google Scholar
    • Export Citation
  • 26.

    Rouleau GAMerel PLutchman Met al: Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature 363:5155211993Rouleau GA Merel P Lutchman M et al: Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature 363:515–521 1993

    • Search Google Scholar
    • Export Citation
  • 27.

    Ruttledge MHAndermann AAPhelan CMet al: Type of mutation in the neurofibromatosis type 2 gene (NF2) frequently determines severity of disease. Am J Hum Genet 59:3313421996Ruttledge MH Andermann AA Phelan CM et al: Type of mutation in the neurofibromatosis type 2 gene (NF2) frequently determines severity of disease. Am J Hum Genet 59:331–342 1996

    • Search Google Scholar
    • Export Citation
  • 28.

    Ruttledge MHSarrazin JRangaratnam Set al: Evidence of complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet 6:1801841994Ruttledge MH Sarrazin J Rangaratnam S et al: Evidence of complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet 6:180–184 1994

    • Search Google Scholar
    • Export Citation
  • 29.

    Seppälä MTHaltia MJSankila RJet al: Long-term outcome after removal of spinal schwannoma: a clinicopathological study of 187 cases. J Neurosurg 83:6216261995Seppälä MT Haltia MJ Sankila RJ et al: Long-term outcome after removal of spinal schwannoma: a clinicopathological study of 187 cases. J Neurosurg 83:621–626 1995

    • Search Google Scholar
    • Export Citation
  • 30.

    Simon Mvon Deimling ALarson JJet al: Allelic losses on chromosome 14, 10, and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression. Cancer Res 55:469647011995Simon M von Deimling A Larson JJ et al: Allelic losses on chromosome 14 10 and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression. Cancer Res 55:4696–4701 1995

    • Search Google Scholar
    • Export Citation
  • 31.

    Sobel RA: Vestibular (acoustic) schwannomas: histologic features in neurofibromatosis 2 and unilateral cases. J Neuropathol Exp Neurol 52:1061131993Sobel RA: Vestibular (acoustic) schwannomas: histologic features in neurofibromatosis 2 and unilateral cases. J Neuropathol Exp Neurol 52:106–113 1993

    • Search Google Scholar
    • Export Citation
  • 32.

    Trofatter JAMacCollin MMRutter JLet al: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72:7918001993Trofatter JA MacCollin MM Rutter JL et al: A novel moesin- ezrin- radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72:791–800 1993

    • Search Google Scholar
    • Export Citation
  • 33.

    Wellenreuther RKraus JALenartz Det al: Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningiomas. Am J Pathol 146:8278321995Wellenreuther R Kraus JA Lenartz D et al: Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningiomas. Am J Pathol 146:827–832 1995

    • Search Google Scholar
    • Export Citation

Cited By

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 64 64 6
Full Text Views 122 122 0
PDF Downloads 74 74 0
EPUB Downloads 0 0 0

PubMed

Google Scholar