Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders

Alim Louis BenabidDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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Pierre PollakDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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Dongming GaoDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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Dominique HoffmannDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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Patricia LimousinDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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Emmanuel GayDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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Isabelle PayenDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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Abdhelhamid BenazzouzDepartment of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Grenoble, France; and Department of Physiology, Jinzhou Medical College, Jinzhou, Liaoning, Peoples Republic of China

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203–214
Volume/Issue:
Volume 84: Issue 2
DOI link:
https://doi.org/10.3171/jns.1996.84.2.0203
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✓ Tremor was suppressed by test stimulation of the thalamic ventralis intermedius (VIM) nucleus at high frequency (130 Hz) during stereotaxy in nonanesthetized patients suffering from Parkinson's disease or essential tremor. Ventralis intermedius stimulation has since been used by the authors over the last 8 years as a treatment in 117 patients with movement disorders (80 cases of Parkinson's disease, 20 cases of essential tremor, and 17 cases of various dyskinesias and dystonias including four multiple sclerosis). Chronic electrodes were stereotactically implanted in the VIM and connected to a programmable stimulator. Results depend on the indication. In Parkinson's disease patients, tremor, but not bradykinesia and rigidity, was selectively suppressed for as long as 8 years. Administration ofl-Dopa was decreased by more than 30% in 40 Parkinson's disease patients. In essential tremor patients, results were satisfactory but deteriorated with time in 18.5% of cases, mainly for patients who presented an action component of their tremor. In other types of dyskinesias (except multiple sclerosis), results were much less favorable. Fifty-nine patients underwent bilateral implantation and 14 other patients received implantation contralateral to a previous thalamotomy. Thirty-seven patients (31.6%) experienced minor side effects, which were always well tolerated and immediately reversible. Three secondary scalp infections led to temporary removal of the implanted material. There was no permanent morbidity. This tremor suppression effect could be due to the inhibition or jamming of a retroactive loop. Chronic VIM stimulation, which is reversible, adaptable, and well tolerated even by patients undergoing bilateral surgery (74 of 117 patients) and by elderly patients, should replace thalamotomy in the regular surgical treatment of parkinsonian and essential tremors.

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Contributor Notes

Address reprint requests to: Alim Louis Benabid, M.D., Department of Clinical and Biological Neurosciences, INSERM Pre-clinical Neurobiology U-318, Joseph Fourier University of Grenoble, Hôpital A. Michallon, Pavilion B, BP 217, 38043 Grenoble, France.
  • 1.

    Adams JE, , Hosobuchi Y, & Fields HL: Stimulation of internal capsule for relief of chronic pain. J Neurosurg 41:740–744, 1974 Adams JE, Hosobuchi Y, Fields HL: Stimulation of internal capsule for relief of chronic pain. J Neurosurg 41:740–744, 1974

    • Search Google Scholar
    • Export Citation
  • 2.

    Akimoto H, , Yamaguchi N, & Pkabe K, et al: On sleep induced through electrical stimulation on dog thalamus. Folia Psychiatr Neurol Jpn 10:117–146, 1956 Akimoto H, Yamaguchi N, Pkabe K, et al: On sleep induced through electrical stimulation on dog thalamus. Folia Psychiatr Neurol Jpn 10:117–146, 1956

    • Search Google Scholar
    • Export Citation
  • 3.

    Albe-Fessard D: Interactions entre recherches fondamentale et clinique. Deux exemples tirés d'une expérience personnelle. Can J Neurol Sci 15:324–332, 1988 Albe-Fessard D: Interactions entre recherches fondamentale et clinique. Deux exemples tirés d'une expérience personnelle. Can J Neurol Sci 15:324–332, 1988

    • Search Google Scholar
    • Export Citation
  • 4.

    Albe-Fessard D: Physiopathologie du Parkinson, in: Le Point sur la Maladie de Parkinson. Bruxelles: Merck Sharp & Dohme, 1973, pp 1–20 Albe-Fessard D: Physiopathologie du Parkinson, in: Le Point sur la Maladie de Parkinson. Bruxelles: Merck Sharp & Dohme, 1973, pp 1–20

    • Search Google Scholar
    • Export Citation
  • 5.

    Albe-Fessard D, , Arfel G, & Guiot G: Activités électriques caractéristiques de quelques structures cérébrales chez l'homme. Ann Chir 17:1185–1214, 1963 Albe-Fessard D, Arfel G, Guiot G: Activités électriques caractéristiques de quelques structures cérébrales chez l'homme. Ann Chir 17:1185–1214, 1963

    • Search Google Scholar
    • Export Citation
  • 6.

    Albe-Fessard D, , Arfel G, & Guiot G, et al: Dérivations d'activités spontanées et évoquées dans les structures cérébrales profondes de l'homme. Rev Neurol 106:89–105, 1962 Albe-Fessard D, Arfel G, Guiot G, et al: Dérivations d'activités spontanées et évoquées dans les structures cérébrales profondes de l'homme. Rev Neurol 106:89–105, 1962

    • Search Google Scholar
    • Export Citation
  • 7.

    Albe-Fessard D, , Arfel G, & Guiot G, et al: [Identification and precise delimitation of certain subcortical structures in man by electrophysiology. Its importance in stereotaxic surgery of dyskinesia.] C R Acad Sci Paris 253:2412–2414, 1961 (Fr) Albe-Fessard D, Arfel G, Guiot G, et al: [Identification and precise delimitation of certain subcortical structures in man by electrophysiology. Its importance in stereotaxic surgery of dyskinesia.] C R Acad Sci Paris 253:2412–2414, 1961 (Fr)

    • Search Google Scholar
    • Export Citation
  • 8.

    Alberts WW, , Feinstein B, & Levin G, et al: Electrical stimulation of therapeutic targets in waking dyskinetic patients. Electroencephalogr Clin Neurophysiol 20:559–566, 1966 Alberts WW, Feinstein B, Levin G, et al: Electrical stimulation of therapeutic targets in waking dyskinetic patients. Electroencephalogr Clin Neurophysiol 20:559–566, 1966

    • Search Google Scholar
    • Export Citation
  • 9.

    Andrew J: Surgical treatment of tremor, in Findley LJ, & Capildeo R (eds): Movement Disorders: Tremor. London: MacMillan, 1984, pp 339–351 Andrew J: Surgical treatment of tremor, in Findley LJ, Capildeo R (eds): Movement Disorders: Tremor. London: MacMillan, 1984, pp 339–351

    • Search Google Scholar
    • Export Citation
  • 10.

    Andrew J, , Fowler CJ, & Harrison MJG: Stereotaxic thalamotomy in 55 cases of dystonia. Brain 106:981–1000, 1983 Andrew J, Fowler CJ, Harrison MJG: Stereotaxic thalamotomy in 55 cases of dystonia. Brain 106:981–1000, 1983

    • Search Google Scholar
    • Export Citation
  • 11.

    Andy OJ: Parafascicular-center median nuclei stimulation for intractable pain and dyskinesia (painful-dyskinesia). App Neurophysiol 43:133–144, 1980 Andy OJ: Parafascicular-center median nuclei stimulation for intractable pain and dyskinesia (painful-dyskinesia). App Neurophysiol 43:133–144, 1980

    • Search Google Scholar
    • Export Citation
  • 12.

    Andy OJ: Thalamic stimulation for control of movement disorders. Appl Neurophysiol 46:107–111, 1983 Andy OJ: Thalamic stimulation for control of movement disorders. Appl Neurophysiol 46:107–111, 1983

    • Search Google Scholar
    • Export Citation
  • 13.

    Benabid AL, , Pollak P, & Gervason C, et al: Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 337:403–406, 1991 Benabid AL, Pollak P, Gervason C, et al: Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 337:403–406, 1991

    • Search Google Scholar
    • Export Citation
  • 14.

    Benabid AL, , Pollak P, & Hommel M, et al: Traitement du tremblement parkinsonien par stimulation chronique du noyau ventral intermédaire du thalamus. Rev Neurol 145:320–323, 1989 Benabid AL, Pollak P, Hommel M, et al: Traitement du tremblement parkinsonien par stimulation chronique du noyau ventral intermédaire du thalamus. Rev Neurol 145:320–323, 1989

    • Search Google Scholar
    • Export Citation
  • 15.

    Benabid AL, , Pollak P, & Louveau A, et al: Chronic VIM-thalamic stimulation in movement disorders, in Crossman AR, & Sambrook MA (eds): Neural Mechanisms in Disorders of Movement. Current Problems in Neurology, Vol 9. London: John Libbey, 1988, pp 413–415 Benabid AL, Pollak P, Louveau A, et al: Chronic VIM-thalamic stimulation in movement disorders, in Crossman AR, Sambrook MA (eds): Neural Mechanisms in Disorders of Movement. Current Problems in Neurology, Vol 9. London: John Libbey, 1988, pp 413–415

    • Search Google Scholar
    • Export Citation
  • 16.

    Benabid AL, , Pollak P, & Louveau A, et al: Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 50:344–346, 1987 Benabid AL, Pollak P, Louveau A, et al: Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 50:344–346, 1987

    • Search Google Scholar
    • Export Citation
  • 17.

    Bertrand G, , Jasper H, & Wong A: Microelectrode study of the human thalamus: functionnal organization in the ventro-basal complex. Confin Neurol 29:81–86, 1967 Bertrand G, Jasper H, Wong A: Microelectrode study of the human thalamus: functionnal organization in the ventro-basal complex. Confin Neurol 29:81–86, 1967

    • Search Google Scholar
    • Export Citation
  • 18.

    Blond S, , Caparros-Lefebvre D, & Parker F, et al: Control of tremor and involuntary movement disorders by chronic stereotactic stimulation of the ventral intermediate thalamic nucleus. J Neurosurg 77:62–68, 1992 Blond S, Caparros-Lefebvre D, Parker F, et al: Control of tremor and involuntary movement disorders by chronic stereotactic stimulation of the ventral intermediate thalamic nucleus. J Neurosurg 77:62–68, 1992

    • Search Google Scholar
    • Export Citation
  • 19.

    Brice J, & McLellan L: Suppression of intention tremor by contingent deep-brain stimulation. Lancet 1:1221–1222, 1980 Brice J, McLellan L: Suppression of intention tremor by contingent deep-brain stimulation. Lancet 1:1221–1222, 1980

    • Search Google Scholar
    • Export Citation
  • 20.

    Burleigh AL, , Horak FB, & Burchiel KJ, et al: Effects of thalamic stimulation on tremor, balance, and step initiation: a single subject study. Mov Disord 8:519–524, 1993 Burleigh AL, Horak FB, Burchiel KJ, et al: Effects of thalamic stimulation on tremor, balance, and step initiation: a single subject study. Mov Disord 8:519–524, 1993

    • Search Google Scholar
    • Export Citation
  • 21.

    Cheshire WP, & Ehle AL: Hemiparkinsonism as a complication of an Ommaya reservoir. Case report. J Neurosurg 73:774–776, 1990 Cheshire WP, Ehle AL: Hemiparkinsonism as a complication of an Ommaya reservoir. Case report. J Neurosurg 73:774–776, 1990

    • Search Google Scholar
    • Export Citation
  • 22.

    Cooper IS: Ligation of anterior choroidal artery for involuntary movements—parkinsonism. Psychiatric Quart 27:317–319, 1953 Cooper IS: Ligation of anterior choroidal artery for involuntary movements—parkinsonism. Psychiatric Quart 27:317–319, 1953

    • Search Google Scholar
    • Export Citation
  • 23.

    Cooper IS: The Neurosurgical Alleviation of Parkinsonism. Springfield, Ill: Charles C Thomas, 1956 Cooper IS: The Neurosurgical Alleviation of Parkinsonism. Springfield, Ill: Charles C Thomas, 1956

    • Search Google Scholar
    • Export Citation
  • 24.

    Cooper IS, & Bravo GJ: Anterior choroidal occlusion, chemo-pallidectomy and chemo-thalamectomy in Parkinsonism, in Fields WS (ed): Pathogenesis and Treatment of Parkinsonism. Springfield, Ill: CC Thomas, 1958, p 325 Cooper IS, Bravo GJ: Anterior choroidal occlusion, chemo-pallidectomy and chemo-thalamectomy in Parkinsonism, in Fields WS (ed): Pathogenesis and Treatment of Parkinsonism. Springfield, Ill: CC Thomas, 1958, p 325

    • Search Google Scholar
    • Export Citation
  • 25.

    Cooper IS, , Upton ARM, & Amin I: Chronic cerebellar stimulation (CCS) and deep brain stimulation (DBS) in involuntary movement disorders. Appl Neurophysiol 45:209–217, 1982 Cooper IS, Upton ARM, Amin I: Chronic cerebellar stimulation (CCS) and deep brain stimulation (DBS) in involuntary movement disorders. Appl Neurophysiol 45:209–217, 1982

    • Search Google Scholar
    • Export Citation
  • 26.

    Coppée G: La pararésonance dans l'excitation par les courants alternatifs sinusoïdaux. Arch Int Physiol Biochim Biophys 40:1–58, 1934 Coppée G: La pararésonance dans l'excitation par les courants alternatifs sinusoïdaux. Arch Int Physiol Biochim Biophys 40:1–58, 1934

    • Search Google Scholar
    • Export Citation
  • 27.

    Cotzias GC, , Van Woert MH, & Schiffer LM: Aromatic amino acids and modification of Parkinsonism. N Engl J Med 276:374–379, 1967 Cotzias GC, Van Woert MH, Schiffer LM: Aromatic amino acids and modification of Parkinsonism. N Engl J Med 276:374–379, 1967

    • Search Google Scholar
    • Export Citation
  • 28.

    Deiber MP, , Pollak P, & Passingham R, et al: Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography. Brain 116:267–279, 1993 Deiber MP, Pollak P, Passingham R, et al: Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography. Brain 116:267–279, 1993

    • Search Google Scholar
    • Export Citation
  • 29.

    Derôme P: Le Noyau Ventral Postérieur de l'Homme. Thesis. Paris, 1965 Derôme P: Le Noyau Ventral Postérieur de l'Homme. Thesis. Paris, 1965

    • Search Google Scholar
    • Export Citation
  • 30.

    Derôme PJ, , Jedynak CP, & Visot A, et al: Traitement des mouvements anormaux par lésions thalamiques. Rev Neurol 142:391–397, 1986 Derôme PJ, Jedynak CP, Visot A, et al: Traitement des mouvements anormaux par lésions thalamiques. Rev Neurol 142:391–397, 1986

    • Search Google Scholar
    • Export Citation
  • 31.

    Fahn S, , Tolosa E, & Marin C: Clinical rating scale for tremor, in Jankovic J, & Tolosa E (eds): Parkinson's Disease and Movement Disorders. Munich: Urban and Schwarzenberg, 1988, pp 225–234 Fahn S, Tolosa E, Marin C: Clinical rating scale for tremor, in Jankovic J, Tolosa E (eds): Parkinson's Disease and Movement Disorders. Munich: Urban and Schwarzenberg, 1988, pp 225–234

    • Search Google Scholar
    • Export Citation
  • 32.

    Fox MW, , Ahlskog JE, & Kelly PJ: Stereotactic ventrolateralis thalamotomy for medically refractory tremor in post-levodopa era Parkinson's disease patients. J Neurosurg 75:723–730, 1991 Fox MW, Ahlskog JE, Kelly PJ: Stereotactic ventrolateralis thalamotomy for medically refractory tremor in post-levodopa era Parkinson's disease patients. J Neurosurg 75:723–730, 1991

    • Search Google Scholar
    • Export Citation
  • 33.

    Goldman MS, , Ahlskog JE, & Kelly PJ: The symptomatic and functional outcome of stereotactic thalamotomy for medically intractable essential tremor. J Neurosurg 76:924–928, 1992 Goldman MS, Ahlskog JE, Kelly PJ: The symptomatic and functional outcome of stereotactic thalamotomy for medically intractable essential tremor. J Neurosurg 76:924–928, 1992

    • Search Google Scholar
    • Export Citation
  • 34.

    Guiot G, , Arfel G, & Derôme P: La chirurgie stéréotaxique des tremblements de repos et d'attitude. Gaz Med 75:4029–4056, 1968 Guiot G, Arfel G, Derôme P: La chirurgie stéréotaxique des tremblements de repos et d'attitude. Gaz Med 75:4029–4056, 1968

    • Search Google Scholar
    • Export Citation
  • 35.

    Guiot G, , Derome P, & Arfel G, et al: Electrophysiological recordings in stereotaxic thalamotomy for parkinsonism. Prog Neurol Surg 5:189–221, 1973 Guiot G, Derome P, Arfel G, et al: Electrophysiological recordings in stereotaxic thalamotomy for parkinsonism. Prog Neurol Surg 5:189–221, 1973

    • Search Google Scholar
    • Export Citation
  • 36.

    Guiot G, , Derôme P, & Trigo JC: Le tremblement d'attitude. Indication la meilleure de la chirurgie stéreotaxique. Presse Med 75:2513–2518, 1967 Guiot G, Derôme P, Trigo JC: Le tremblement d'attitude. Indication la meilleure de la chirurgie stéreotaxique. Presse Med 75:2513–2518, 1967

    • Search Google Scholar
    • Export Citation
  • 37.

    Hassler R: Forels Haubenfaszikel als Vestibuläre Empfindungsbahn mit Bemerkungen über einige andere sekundäre Bahnen des Vestibularis und Trigeminus. Arch Psychiatry 180:23–53, 1948 Hassler R: Forels Haubenfaszikel als Vestibuläre Empfindungsbahn mit Bemerkungen über einige andere sekundäre Bahnen des Vestibularis und Trigeminus. Arch Psychiatry 180:23–53, 1948

    • Search Google Scholar
    • Export Citation
  • 38.

    Hassler R: The influence of stimulations and coagulations in the human thalamus on the tremor at rest and its physiopathologic mechanism. Excerpta Medica Foundation 2:637–642, 1955 Hassler R: The influence of stimulations and coagulations in the human thalamus on the tremor at rest and its physiopathologic mechanism. Excerpta Medica Foundation 2:637–642, 1955

    • Search Google Scholar
    • Export Citation
  • 39.

    Hassler R: The pathological and pathophysiological basis of tremor and parkinsonism. Excerpta Medica Foundation 1:29–40, 1955 [Unverified] Hassler R: The pathological and pathophysiological basis of tremor and parkinsonism. Excerpta Medica Foundation 1:29–40, 1955 [Unverified]

    • Search Google Scholar
    • Export Citation
  • 40.

    Hassler R, , Riechert T, & Mundinger F, et al: Physiological observations on stereotaxic operations in extrapyramidal motor disturbances. Brain 83:337–350, 1960 Hassler R, Riechert T, Mundinger F, et al: Physiological observations on stereotaxic operations in extrapyramidal motor disturbances. Brain 83:337–350, 1960

    • Search Google Scholar
    • Export Citation
  • 41.

    Hess WR: The diencephalic sleep center, in Adrian ED (ed): Brain Mechanisms and Consciousness. Springfield, Ill: CC Thomas, 1954, pp 117–136 Hess WR: The diencephalic sleep center, in Adrian ED (ed): Brain Mechanisms and Consciousness. Springfield, Ill: CC Thomas, 1954, pp 117–136

    • Search Google Scholar
    • Export Citation
  • 42.

    Hirai T, , Miyazaki M, & Nakajima H, et al: The correlation between tremor characteristics and the predicted volume of effective lesions in stereotaxic nucleus ventralis intermedius thalamotomy. Brain 106:1001–1018, 1983 Hirai T, Miyazaki M, Nakajima H, et al: The correlation between tremor characteristics and the predicted volume of effective lesions in stereotaxic nucleus ventralis intermedius thalamotomy. Brain 106:1001–1018, 1983

    • Search Google Scholar
    • Export Citation
  • 43.

    Hosobuchi Y: Subcortical electrical stimulation for control of intractable pain in humans. Report of 122 cases (1970–1984). J Neurosurg 64:543–553, 1986 Hosobuchi Y: Subcortical electrical stimulation for control of intractable pain in humans. Report of 122 cases (1970–1984). J Neurosurg 64:543–553, 1986

    • Search Google Scholar
    • Export Citation
  • 44.

    Hunter J, & Jasper HH: Effects of thalamic stimulation in unanaesthetised animals. The arrest reaction and petit mal-like seizures, activation patterns and generalized convulsions. Electroencephalogr Clin Neurophysiol 1:305–324, 1949 Hunter J, Jasper HH: Effects of thalamic stimulation in unanaesthetised animals. The arrest reaction and petit mal-like seizures, activation patterns and generalized convulsions. Electroencephalogr Clin Neurophysiol 1:305–324, 1949

    • Search Google Scholar
    • Export Citation
  • 45.

    Ilinsky IA, & Kultas-Ilinsky K: Sagittal cytoarchitectonic maps of the Macaca mulatta thalamus with a revised nomenclature of the motor-related nuclei validated by observations on their connectivity. J Comp Neurol 262:331–364, 1987 Ilinsky IA, Kultas-Ilinsky K: Sagittal cytoarchitectonic maps of the Macaca mulatta thalamus with a revised nomenclature of the motor-related nuclei validated by observations on their connectivity. J Comp Neurol 262:331–364, 1987

    • Search Google Scholar
    • Export Citation
  • 46.

    Jasper HH: Recording from microelectrode in stereotactic surgery for Parkinson's disease. J Neurosurg 24:219–221, 1966 Jasper HH: Recording from microelectrode in stereotactic surgery for Parkinson's disease. J Neurosurg 24:219–221, 1966

    • Search Google Scholar
    • Export Citation
  • 47.

    Jasper HH: Unspecific thalamocortical relations, in American Physiological Society (eds): Handbook of Physiology. Sect 1. Neurophysiology. Washington DC: J Field, 1960, pp 1307–1321 Jasper HH: Unspecific thalamocortical relations, in American Physiological Society (eds): Handbook of Physiology. Sect 1. Neurophysiology. Washington DC: J Field, 1960, pp 1307–1321

    • Search Google Scholar
    • Export Citation
  • 48.

    Joffroy AJ, & Lamarre Y: Rhythmic unit firing in the precentral cortex in relation to postural tremor in a deafferented limb. Brain Res 27:386–389, 1971 Joffroy AJ, Lamarre Y: Rhythmic unit firing in the precentral cortex in relation to postural tremor in a deafferented limb. Brain Res 27:386–389, 1971

    • Search Google Scholar
    • Export Citation
  • 49.

    Jones EG: The Thalamus. New York: Plenum Press, 1985, p 935 Jones EG: The Thalamus. New York: Plenum Press, 1985, p 935

  • 50.

    Kelly PJ, , Derôme P, & Guiot G: Thalamic spatial variability and the surgical results of lesions placed with neurophysiologic control. Surg Neurol 9:307–315, 1978 Kelly PJ, Derôme P, Guiot G: Thalamic spatial variability and the surgical results of lesions placed with neurophysiologic control. Surg Neurol 9:307–315, 1978

    • Search Google Scholar
    • Export Citation
  • 51.

    Laitinen LV: Brain targets in surgery for Parkinson's disease. Results of a survey of neurosurgeons. J Neurosurg 62:349–351, 1985 Laitinen LV: Brain targets in surgery for Parkinson's disease. Results of a survey of neurosurgeons. J Neurosurg 62:349–351, 1985

    • Search Google Scholar
    • Export Citation
  • 52.

    Lamarre Y, & Mercier LA: Neurophysiological studies of harmaline-induced tremor in the cat. J Physiol Pharmacol 49:1049–1058, 1971 Lamarre Y, Mercier LA: Neurophysiological studies of harmaline-induced tremor in the cat. J Physiol Pharmacol 49:1049–1058, 1971

    • Search Google Scholar
    • Export Citation
  • 53.

    Larson SJ, , Sances A Jr, & Wetzel N: Cerebello-pallido-thalamic connections in man. Appl Neurophysiol 45:549–562, 1982 Larson SJ, Sances A Jr, Wetzel N: Cerebello-pallido-thalamic connections in man. Appl Neurophysiol 45:549–562, 1982

    • Search Google Scholar
    • Export Citation
  • 54.

    Lenz FA, , Tasker RR, & Kwan HC, et al: Single unit analysis of the human ventral thalamic nuclear group: correlation of thalamic “tremor cells” with the 3–6 Hz component of the parkinsonian tremor. J Neurosci 8:754–764, 1988 Lenz FA, Tasker RR, Kwan HC, et al: Single unit analysis of the human ventral thalamic nuclear group: correlation of thalamic “tremor cells” with the 3–6 Hz component of the parkinsonian tremor. J Neurosci 8:754–764, 1988

    • Search Google Scholar
    • Export Citation
  • 55.

    Marks PV, , Wild AM, & Gleave JRW: Long-term abolition of parkinsonian tremor following attempted ventriculography. Br J Neurosurg 5:505–508, 1991 Marks PV, Wild AM, Gleave JRW: Long-term abolition of parkinsonian tremor following attempted ventriculography. Br J Neurosurg 5:505–508, 1991

    • Search Google Scholar
    • Export Citation
  • 56.

    Matsumoto K, , Asano T, & Baba T, et al: Long-term follow-up results of bilateral thalamotomy for parkinsonism. Appl Neurophysiol 39:257–260, 1976/77 Matsumoto K, Asano T, Baba T, et al: Long-term follow-up results of bilateral thalamotomy for parkinsonism. Appl Neurophysiol 39:257–260, 1976/77

    • Search Google Scholar
    • Export Citation
  • 57.

    Matsumoto K, , Shichijo F, & Fukami T: Long-term follow-up review of cases of Parkinson's disease after unilateral or bilateral thalamotomy. J Neurosurg 60:1033–1044, 1984 Matsumoto K, Shichijo F, Fukami T: Long-term follow-up review of cases of Parkinson's disease after unilateral or bilateral thalamotomy. J Neurosurg 60:1033–1044, 1984

    • Search Google Scholar
    • Export Citation
  • 58.

    Mazars G, , Merienne L, & Cioloca C: Control of dyskinesias due to sensory deafferentation by means of thalamic stimulation. Acta Neurochir Suppl 30:239–243, 1980 Mazars G, Merienne L, Cioloca C: Control of dyskinesias due to sensory deafferentation by means of thalamic stimulation. Acta Neurochir Suppl 30:239–243, 1980

    • Search Google Scholar
    • Export Citation
  • 59.

    Meyers R: Surgical interruption of the pallidofugal fibers. Its effect on the syndrome of paralysis agitans and technical considerations in its applications. NY State J Med 42:317–325, 1942 Meyers R: Surgical interruption of the pallidofugal fibers. Its effect on the syndrome of paralysis agitans and technical considerations in its applications. NY State J Med 42:317–325, 1942

    • Search Google Scholar
    • Export Citation
  • 60.

    Monnier M, , Kalberer M, & Krupp P: Functional antagonism between diffuse reticular and intralaminary recruiting projections in the medial thalamus. Exp Neurol 2:271–289, 1960 Monnier M, Kalberer M, Krupp P: Functional antagonism between diffuse reticular and intralaminary recruiting projections in the medial thalamus. Exp Neurol 2:271–289, 1960

    • Search Google Scholar
    • Export Citation
  • 61.

    Mundinger F, & Neumüller H: Programmed stimulation for control of chronic pain and motor diseases. Appl Neurophysiol 45:102–111, 1982 Mundinger F, Neumüller H: Programmed stimulation for control of chronic pain and motor diseases. Appl Neurophysiol 45:102–111, 1982

    • Search Google Scholar
    • Export Citation
  • 62.

    Nagaseki Y, , Shibazaki T, & Hirai T, et al: Long term follow-up results of selective VIM-thalamotomy. J Neurosurg 65:296–302, 1986 Nagaseki Y, Shibazaki T, Hirai T, et al: Long term follow-up results of selective VIM-thalamotomy. J Neurosurg 65:296–302, 1986

    • Search Google Scholar
    • Export Citation
  • 63.

    Narabayashi H: Stereotaxic Vim thalamotomy for treatment of tremor. Eur Neurol 29 (Suppl 1):29–32, 1989 Narabayashi H: Stereotaxic Vim thalamotomy for treatment of tremor. Eur Neurol 29 (Suppl 1):29–32, 1989

    • Search Google Scholar
    • Export Citation
  • 64.

    Nashold BS, & Slaughter DG: Some observations on tremors, in Gillingham FJ (ed): Third Symposium on Parkinson's Disease, 1968. Livingstone Ltd, 1969, pp 241–246 [Unverified] Nashold BS, Slaughter DG: Some observations on tremors, in Gillingham FJ (ed): Third Symposium on Parkinson's Disease, 1968. Livingstone Ltd, 1969, pp 241–246 [Unverified]

    • Search Google Scholar
    • Export Citation
  • 65.

    Ohye C: Rôle des noyaux thalamiques dans l'hypertonie et le tremblement de la maladie de Parkinson. Rev Neurol 142:362–367, 1986 Ohye C: Rôle des noyaux thalamiques dans l'hypertonie et le tremblement de la maladie de Parkinson. Rev Neurol 142:362–367, 1986

    • Search Google Scholar
    • Export Citation
  • 66.

    Ohye C, , Bouchard R, & Larochelle L, et al: Effect of dorsal rhizotomy on postural tremor in the monkey. Exp Brain Res 10:140–150, 1970 Ohye C, Bouchard R, Larochelle L, et al: Effect of dorsal rhizotomy on postural tremor in the monkey. Exp Brain Res 10:140–150, 1970

    • Search Google Scholar
    • Export Citation
  • 67.

    Ohye C, , Fukamashi A, & Narabayashi H: Spontaneous and evoked activity of sensory neurons and their organization in the human thalamus. Z Neurol 203:219–234, 1972 Ohye C, Fukamashi A, Narabayashi H: Spontaneous and evoked activity of sensory neurons and their organization in the human thalamus. Z Neurol 203:219–234, 1972

    • Search Google Scholar
    • Export Citation
  • 68.

    Ohye C, , Hirai T, & Miyazaki M, et al: Vim thalamotomy for the treatment of various kinds of tremor. Appl Neurophysiol 45:275–280, 1982 Ohye C, Hirai T, Miyazaki M, et al: Vim thalamotomy for the treatment of various kinds of tremor. Appl Neurophysiol 45:275–280, 1982

    • Search Google Scholar
    • Export Citation
  • 69.

    Ohye C, , Imai S, & Nakajima H, et al: Experimental study of spontaneous postural tremor induced by a more successful tremor-producing procedure in the monkey. Adv Neurol 24:83–91, 1979 Ohye C, Imai S, Nakajima H, et al: Experimental study of spontaneous postural tremor induced by a more successful tremor-producing procedure in the monkey. Adv Neurol 24:83–91, 1979

    • Search Google Scholar
    • Export Citation
  • 70.

    Ohye C, , Maeda T, & Narabayashi H: Physiologically defined Vim nucleus. Its special reference to control of tremor. Appl Neurophysiol 39:285–295, 1977 Ohye C, Maeda T, Narabayashi H: Physiologically defined Vim nucleus. Its special reference to control of tremor. Appl Neurophysiol 39:285–295, 1977

    • Search Google Scholar
    • Export Citation
  • 71.

    Ohye C, , Nakamura R, & Fukamachi A, et al: Recording and stimulation of the ventralis intermedius nucleus of the human thalamus. Confin Neurol 37:258, 1975 Ohye C, Nakamura R, Fukamachi A, et al: Recording and stimulation of the ventralis intermedius nucleus of the human thalamus. Confin Neurol 37:258, 1975

    • Search Google Scholar
    • Export Citation
  • 72.

    Ohye C, & Narabayashi H: Physiological study of presumed ventralis intermedius neurons in the human thalamus. J Neurosurg 50:290–297, 1979 Ohye C, Narabayashi H: Physiological study of presumed ventralis intermedius neurons in the human thalamus. J Neurosurg 50:290–297, 1979

    • Search Google Scholar
    • Export Citation
  • 73.

    Ohye C, , Saito Y, & Fukamashi A, et al: An analysis of spontaneous rhythmic and non-rhythmic burst discharges in the human thalamus. J Neurol Sci 22:245–259, 1974 Ohye C, Saito Y, Fukamashi A, et al: An analysis of spontaneous rhythmic and non-rhythmic burst discharges in the human thalamus. J Neurol Sci 22:245–259, 1974

    • Search Google Scholar
    • Export Citation
  • 74.

    Ohye C, , Shibazaki T, & Hirai T, et al: Further physiological observations on the ventralis intermedius neurons in the human thalamus. J Neurophysiol 61:488–500, 1989 Ohye C, Shibazaki T, Hirai T, et al: Further physiological observations on the ventralis intermedius neurons in the human thalamus. J Neurophysiol 61:488–500, 1989

    • Search Google Scholar
    • Export Citation
  • 75.

    Ohye C, , Shibazaki T, & Hirai T, et al: A special role of the parvocellular red nucleus in lesion-induced spontaneous tremor in monkeys. Behav Brain Res 28:241–243, 1988 Ohye C, Shibazaki T, Hirai T, et al: A special role of the parvocellular red nucleus in lesion-induced spontaneous tremor in monkeys. Behav Brain Res 28:241–243, 1988

    • Search Google Scholar
    • Export Citation
  • 76.

    Ohye C, , Shibazaki T, & Nagaseki Y, et al: Possible descending pathways mediating spontaneous tremor in monkeys. Adv Neurol 40:181–188, 1984 Ohye C, Shibazaki T, Nagaseki Y, et al: Possible descending pathways mediating spontaneous tremor in monkeys. Adv Neurol 40:181–188, 1984

    • Search Google Scholar
    • Export Citation
  • 77.

    Pollak P, , Benabid AL, & Gervason CL, et al: Long-term effects of chronic stimulation of the ventral intermediate thalamic nucleus in different types of tremor. Adv Neurol 60:408–413, 1993 Pollak P, Benabid AL, Gervason CL, et al: Long-term effects of chronic stimulation of the ventral intermediate thalamic nucleus in different types of tremor. Adv Neurol 60:408–413, 1993

    • Search Google Scholar
    • Export Citation
  • 78.

    Raeva S: Localization in human thalamus of units triggered during “verbal commands,” voluntary movements and tremor. Electroencephalogr Clin Neurophysiol 63:160–173, 1986 Raeva S: Localization in human thalamus of units triggered during “verbal commands,” voluntary movements and tremor. Electroencephalogr Clin Neurophysiol 63:160–173, 1986

    • Search Google Scholar
    • Export Citation
  • 79.

    Sanderson P, , Mavoungou R, & Albe-Fessard D: Changes in substantia nigra pars reticulata activity following lesions of the substantia nigra pars compacta. Neurosci Lett 67:25–30, 1986 Sanderson P, Mavoungou R, Albe-Fessard D: Changes in substantia nigra pars reticulata activity following lesions of the substantia nigra pars compacta. Neurosci Lett 67:25–30, 1986

    • Search Google Scholar
    • Export Citation
  • 80.

    Schaltenbrandt G, , Spuler H, & Wahren W, et al: Electroanatomy of the thalamic ventro-oral nucleus based on stereotaxic stimulation in man. Z Neurol 199:259–276, 1971 Schaltenbrandt G, Spuler H, Wahren W, et al: Electroanatomy of the thalamic ventro-oral nucleus based on stereotaxic stimulation in man. Z Neurol 199:259–276, 1971

    • Search Google Scholar
    • Export Citation
  • 81.

    Schnider SM, , Kwong RH, & Kwan HC, et al: Detection of feedback in the central nervous system of parkinsonian patients. IEEE WA 11:291–294, 1986 Schnider SM, Kwong RH, Kwan HC, et al: Detection of feedback in the central nervous system of parkinsonian patients. IEEE WA 11:291–294, 1986

    • Search Google Scholar
    • Export Citation
  • 82.

    Sem-Jacobsen CW: Depth-electrographic observations related to Parkinson's disease. Recording and electrical stimulation in the area around the third ventricle. J Neurosurg 24:388–402, 1966 Sem-Jacobsen CW: Depth-electrographic observations related to Parkinson's disease. Recording and electrical stimulation in the area around the third ventricle. J Neurosurg 24:388–402, 1966

    • Search Google Scholar
    • Export Citation
  • 83.

    Siegfried J: Chronic electrical stimulation of the VL-VPL complex and of the pallidum in the treatment of extrapyramidal and cerebellar disorders: personal experience since 1985, in XIIth Meeting of the World Society for Stereotactic and Functional Neurosurgery. Abstract 125, Ixtapa, Mexico, 1993 [Unverified] Siegfried J: Chronic electrical stimulation of the VL-VPL complex and of the pallidum in the treatment of extrapyramidal and cerebellar disorders: personal experience since 1985, in XIIth Meeting of the World Society for Stereotactic and Functional Neurosurgery. Abstract 125, Ixtapa, Mexico, 1993 [Unverified]

    • Search Google Scholar
    • Export Citation
  • 84.

    Siegfried J: Effets de la stimulation du noyau sensitif du thalamus sur les dyskinésies et la spasticité. Rev Neurol 142:380–383, 1986 Siegfried J: Effets de la stimulation du noyau sensitif du thalamus sur les dyskinésies et la spasticité. Rev Neurol 142:380–383, 1986

    • Search Google Scholar
    • Export Citation
  • 85.

    Siegfried J: Neurosurgical treatment of Parkinson's disease. Present indications and value, in Rinne UK, , Klingler M, & Stamm G (eds): Parkinson's Disease. Current Progress, Problems and Management. Amsterdam: Elsevier, 1979, pp 369–376 Siegfried J: Neurosurgical treatment of Parkinson's disease. Present indications and value, in Rinne UK, Klingler M, Stamm G (eds): Parkinson's Disease. Current Progress, Problems and Management. Amsterdam: Elsevier, 1979, pp 369–376

    • Search Google Scholar
    • Export Citation
  • 86.

    Speelman JD: Parkinson's Disease and Stereotaxic Neurosurgery. Thesis. Amsterdam: Rodopi, 1991, p 218 Speelman JD: Parkinson's Disease and Stereotaxic Neurosurgery. Thesis. Amsterdam: Rodopi, 1991, p 218

    • Search Google Scholar
    • Export Citation
  • 87.

    Stellar S, & Cooper IS: Mortality and morbidity in cryothalamectomy for parkinsonism. A statistical study of 2868 consecutive operations. J Neurosurg 28:459–467, 1968 Stellar S, Cooper IS: Mortality and morbidity in cryothalamectomy for parkinsonism. A statistical study of 2868 consecutive operations. J Neurosurg 28:459–467, 1968

    • Search Google Scholar
    • Export Citation
  • 88.

    Talairach J, , David M, & Tournoux P, et al: Atlas d'Anatomie Stéréotaxique des Noyaux Gris Centraux. Paris: Masson, 1957, p 294 [Unverified] Talairach J, David M, Tournoux P, et al: Atlas d'Anatomie Stéréotaxique des Noyaux Gris Centraux. Paris: Masson, 1957, p 294 [Unverified]

    • Search Google Scholar
    • Export Citation
  • 89.

    Talairach J, , de Ajuriaguerra J, & David M: A propos des coagulations thérapeutiques sous-corticales: étude topographique du système ventriculaire en fonction des noyaux gris centraux. Presse Med 58:697–701, 1950 Talairach J, de Ajuriaguerra J, David M: A propos des coagulations thérapeutiques sous-corticales: étude topographique du système ventriculaire en fonction des noyaux gris centraux. Presse Med 58:697–701, 1950

    • Search Google Scholar
    • Export Citation
  • 90.

    Talairach J, , Hecaen H, & David M, et al: Recherches sur la coagulation thérapeutique des structures sous-corticales chez l'homme. Rev Neurol 81:4–24, 1949 Talairach J, Hecaen H, David M, et al: Recherches sur la coagulation thérapeutique des structures sous-corticales chez l'homme. Rev Neurol 81:4–24, 1949

    • Search Google Scholar
    • Export Citation
  • 91.

    Taren J, , Guiot G, & Derome P, et al: Hazards of stereotaxic thalamectomy. Added safety factor in corroborating X-ray target localization with neurophysiological methods. J Neurosurg 29:173–182, 1968 Taren J, Guiot G, Derome P, et al: Hazards of stereotaxic thalamectomy. Added safety factor in corroborating X-ray target localization with neurophysiological methods. J Neurosurg 29:173–182, 1968

    • Search Google Scholar
    • Export Citation
  • 92.

    Tasker R: Effets sensitifs et moteurs de la stimulation thalamique chez l'homme Applications cliniques. Rev Neurol 142:316–326, 1986 Tasker R: Effets sensitifs et moteurs de la stimulation thalamique chez l'homme Applications cliniques. Rev Neurol 142:316–326, 1986

    • Search Google Scholar
    • Export Citation
  • 93.

    Tasker RR, , Organ LW, & Hawrylyshyn P: Investigation of the surgical target for alleviation of involuntary movement disorders. Appl Neurophysiol 45:261–274, 1982 Tasker RR, Organ LW, Hawrylyshyn P: Investigation of the surgical target for alleviation of involuntary movement disorders. Appl Neurophysiol 45:261–274, 1982

    • Search Google Scholar
    • Export Citation
  • 94.

    Tasker RR, , Siquiera J, & Hawrylyshyn P, et al: What happened to Vim thalamotomy for Parkinson's disease? Appl Neurophysiol 46:68–83, 1983 Tasker RR, Siquiera J, Hawrylyshyn P, et al: What happened to Vim thalamotomy for Parkinson's disease? Appl Neurophysiol 46:68–83, 1983

    • Search Google Scholar
    • Export Citation
  • 95.

    Toth S, , Solyom A, & Vajda J, et al: The rhythmic properties of the motor system. Stereotact Funct Neurosurg 53:95–104, 1989 Toth S, Solyom A, Vajda J, et al: The rhythmic properties of the motor system. Stereotact Funct Neurosurg 53:95–104, 1989

    • Search Google Scholar
    • Export Citation
  • 96.

    Van Buren JM, , Borke RC, & Modesti LM: Sensory and nonsensory portions of the nucleus “ventralis posterior” thalami of the chimpanzee and man. J Neurosurg 45:37–48, 1976 Van Buren JM, Borke RC, Modesti LM: Sensory and nonsensory portions of the nucleus “ventralis posterior” thalami of the chimpanzee and man. J Neurosurg 45:37–48, 1976

    • Search Google Scholar
    • Export Citation
  • 97.

    Velasco F, , Velasco M, & Ogarrio C, et al: Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia 28:421–430, 1987 Velasco F, Velasco M, Ogarrio C, et al: Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia 28:421–430, 1987

    • Search Google Scholar
    • Export Citation

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