Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization

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✓ Functional magnetic resonance (MR) imaging was performed using a 1.5-tesla MR system to localize sensorimotor cortex. Six neurologically normal subjects were studied by means of axial gradient-echo images with a motor task and one or more sensory tasks: 1) electrical stimulation of the median nerve; 2) continuous brushing over the thenar region; and 3) pulsed flow of compressed air over the palm and digits. An increased MR signal was observed in or near the central sulcus, consistent with the location of primary sensory and motor cortex.

Four patients were studied using echo planar imaging sequences and motor and sensory tasks. Three patients had focal refractory seizures secondary to a lesion impinging on sensorimotor cortex. Activation seen on functional MR imaging was coextensive with the location of the sensorimotor area determined by evoked potentials and electrical stimulation. Functional MR imaging provides a useful noninvasive method of localization and functional assessment of sensorimotor cortex.

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Address reprint requests to: Aina Puce, Ph.D., Neuropsychology Laboratory/116B1, Veterans Affairs Medical Center, West Haven, Connecticut 06516.
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References
  • 1.

    Allison TMcCarthy GWood CCet al: Human cortical potentials evoked by stimulation of the median nerve. I. Cytoarchitectonic areas generating short-latency activity. J Neurophysiol 62:6947101989Allison T McCarthy G Wood CC et al: Human cortical potentials evoked by stimulation of the median nerve. I. Cytoarchitectonic areas generating short-latency activity. J Neurophysiol 62:694–710 1989

    • Search Google Scholar
    • Export Citation
  • 2.

    Allison TMcCarthy GWood CCet al: Human cortical potentials evoked by stimulation of the median nerve. II. Cytoarchitectonic areas generating long-latency activity. J Neurophysiol 62:7117221989Allison T McCarthy G Wood CC et al: Human cortical potentials evoked by stimulation of the median nerve. II. Cytoarchitectonic areas generating long-latency activity. J Neurophysiol 62:711–722 1989

    • Search Google Scholar
    • Export Citation
  • 3.

    Allison TWood CCMcCarthy Get al: Cortical somatosensory evoked potentials. II. Effects of excision of somatosensory or motor cortex in humans and monkeys. J Neurophysiol 66:64821991Allison T Wood CC McCarthy G et al: Cortical somatosensory evoked potentials. II. Effects of excision of somatosensory or motor cortex in humans and monkeys. J Neurophysiol 66:64–82 1991

    • Search Google Scholar
    • Export Citation
  • 4.

    Buchner HAdams LKnepper Aet al: Preoperative localization of the central sulcus by dipole source analysis of early somatosensory evoked potentials and three-dimensional magnetic resonance imaging. J Neurosurg 80:8498561994Buchner H Adams L Knepper A et al: Preoperative localization of the central sulcus by dipole source analysis of early somatosensory evoked potentials and three-dimensional magnetic resonance imaging. J Neurosurg 80:849–856 1994

    • Search Google Scholar
    • Export Citation
  • 5.

    Connelly AJackson GDFrackowiak RSJet al: Functional mapping of activated human primary cortex with a clinical MR imaging system. Radiology 188:1251301993Connelly A Jackson GD Frackowiak RSJ et al: Functional mapping of activated human primary cortex with a clinical MR imaging system. Radiology 188:125–130 1993

    • Search Google Scholar
    • Export Citation
  • 6.

    Constable RTKennan RPPuce Aet al: Functional NMR imaging using fast spin echo at 1.5 T. Magn Reson Med 31:6866901994Constable RT Kennan RP Puce A et al: Functional NMR imaging using fast spin echo at 1.5 T. Magn Reson Med 31:686–690 1994

    • Search Google Scholar
    • Export Citation
  • 7.

    Constable RTMcCarthy GAllison Tet al: Functional brain imaging at 1.5 T using conventional gradient echo MR imaging techniques. Magn Reson Imaging 11:4514591993Constable RT McCarthy G Allison T et al: Functional brain imaging at 1.5 T using conventional gradient echo MR imaging techniques. Magn Reson Imaging 11:451–459 1993

    • Search Google Scholar
    • Export Citation
  • 8.

    Jack CR JrThompson RMButts RKet al: Sensory motor cortex: correlation of presurgical mapping with functional MR imaging and invasive cortical mapping. Radiology 190:85921994Jack CR Jr Thompson RM Butts RK et al: Sensory motor cortex: correlation of presurgical mapping with functional MR imaging and invasive cortical mapping. Radiology 190:85–92 1994

    • Search Google Scholar
    • Export Citation
  • 9.

    Kim SGAshe JGeorgopoulos APet al: Functional imaging of human motor cortex at high magnetic field. J Neurophysiol 69:2973021993Kim SG Ashe J Georgopoulos AP et al: Functional imaging of human motor cortex at high magnetic field. J Neurophysiol 69:297–302 1993

    • Search Google Scholar
    • Export Citation
  • 10.

    Kwong KKBelliveau JWChesler DAet al: Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89:567556791992Kwong KK Belliveau JW Chesler DA et al: Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89:5675–5679 1992

    • Search Google Scholar
    • Export Citation
  • 11.

    McCarthy GAllison TSpencer DD: Location of the face area of human sensorimotor cortex by intracranial recording of somatosensory evoked potentials. J Neurosurg 79:8748841993McCarthy G Allison T Spencer DD: Location of the face area of human sensorimotor cortex by intracranial recording of somatosensory evoked potentials. J Neurosurg 79:874–884 1993

    • Search Google Scholar
    • Export Citation
  • 12.

    McCarthy GWood CCAllison T: Cortical somatosensory evoked potentials. I. Recordings in the monkey Macaca fascicularis. J Neurophysiol 66:53631991McCarthy G Wood CC Allison T: Cortical somatosensory evoked potentials. I. Recordings in the monkey Macaca fascicularis. J Neurophysiol 66:53–63 1991

    • Search Google Scholar
    • Export Citation
  • 13.

    Ogawa SLee TMKay ARet al: Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87:986898721991Ogawa S Lee TM Kay AR et al: Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87:9868–9872 1991

    • Search Google Scholar
    • Export Citation
  • 14.

    Ogawa SLee TMNayak ASet al: Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14:68781990Ogawa S Lee TM Nayak AS et al: Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14:68–78 1990

    • Search Google Scholar
    • Export Citation
  • 15.

    Rumeau CTzourio NMurayama Net al: Location of hand function in the sensorimotor cortex: MR and functional correlation. AJNR 15:5675721994Rumeau C Tzourio N Murayama N et al: Location of hand function in the sensorimotor cortex: MR and functional correlation. AJNR 15:567–572 1994

    • Search Google Scholar
    • Export Citation
  • 16.

    Schneider WCasey BJNoll D: Functional MRI mapping of stimulation rate effects across visual processing stages. Human Brain Mapping 1:1171331993/1994Schneider W Casey BJ Noll D: Functional MRI mapping of stimulation rate effects across visual processing stages. Human Brain Mapping 1:117–133 1993/1994

    • Search Google Scholar
    • Export Citation
  • 17.

    Shulman RGBlamire AMRothman DLet al: Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proc Natl Acad Sci USA 90:312731331993Shulman RG Blamire AM Rothman DL et al: Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proc Natl Acad Sci USA 90:3127–3133 1993

    • Search Google Scholar
    • Export Citation
  • 18.

    Spencer SSSpencer DDWilliamson PDet al: The localizing value of depth electroencephalography in 32 patients with refractory epilepsy. Ann Neurol 12:2482531982Spencer SS Spencer DD Williamson PD et al: The localizing value of depth electroencephalography in 32 patients with refractory epilepsy. Ann Neurol 12:248–253 1982

    • Search Google Scholar
    • Export Citation
  • 19.

    Wood CCSpencer DDAllison Tet al: Localization of human sensorimotor cortex during surgery by cortical surface recording of somatosensory evoked potentials. J Neurosurg 68:991111988Wood CC Spencer DD Allison T et al: Localization of human sensorimotor cortex during surgery by cortical surface recording of somatosensory evoked potentials. J Neurosurg 68:99–111 1988

    • Search Google Scholar
    • Export Citation
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