Hormone receptors in initially excised versus recurrent intracranial meningiomas

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  • 1 Departments of Neurosurgery, Oncology, and Neurology, Beilinson Medical Center, Petah Tiqva; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; and Department of Endocrinology, Sheba Medical Center, Tel Hashomer, Israel
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✓ Intracranial meningiomas from 51 surgical patients consecutively treated during an 18-month period were evaluated for the presence of receptors to progesterone and estrogen. Thirty-eight patients underwent initial resection during this time and 13 underwent reoperation for recurrent disease. With positivity defined as receptor levels greater than 10 fmol/mg of cytosol protein, 84% of all the meningiomas were positive for progesterone receptors, whereas only 33% were positive for estrogen receptors. Among the recurrent meningiomas, 92% showed evidence of progesterone receptors and 54% of estrogen receptors; these figures were not significantly different from the corresponding incidence of 82% and 26%, respectively, among the initially excised tumors. However, the mean concentration of progesterone receptors in the recurrent tumor group was significantly higher when compared to the concentration in the initially excised group (p < 0.02).

Twenty meningiomas (39%) were considered to be radiation-induced, since they were removed from patients who had received scalp irradiation during childhood. The incidence and concentration of receptors in the radiation-induced tumors were generally comparable to those in the spontaneous meningiomas.

This study confirms previous reports of a high incidence of hormone receptors, mainly for progesterone, in meningiomas. In addition, it shows that in recurrent meningiomas these receptors persist and even increase. The results therefore support hormone treatment for nonresectable meningiomas, especially at recurrence.

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  • 1.

    Adams EF, , Schrell UMH, & Fahlbusch R, et al: Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. J Neurosurg 73:750755, 1990 Adams EF, Schrell UMH, Fahlbusch R, et al: Hormonal dependency of cerebral meningiomas. Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas. J Neurosurg 73:750–755, 1990

    • Search Google Scholar
    • Export Citation
  • 2.

    Blankenstein MA, , Blaauw G, & Lamberts SWJ: Progestin and estrogen receptors in human meningioma. Clin Neuropharmacol 7:363367, 1984 Blankenstein MA, Blaauw G, Lamberts SWJ: Progestin and estrogen receptors in human meningioma. Clin Neuropharmacol 7:363–367, 1984

    • Search Google Scholar
    • Export Citation
  • 3.

    Crone KR, , Challa VR, & Kute TE, et al: The relationship between flow cytometric features and clinical behavior of meningiomas. J Neuropathol Exp Neurol 44:313, 1985 (Abstract) Crone KR, Challa VR, Kute TE, et al: The relationship between flow cytometric features and clinical behavior of meningiomas. J Neuropathol Exp Neurol 44:313, 1985 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 4.

    Geier A, , Beery R, & Levran D, et al: Unoccupied nuclear receptors for estrogen in human endometrial tissue. J Clin Endocrinol Metab 50:541545, 1980 Geier A, Beery R, Levran D, et al: Unoccupied nuclear receptors for estrogen in human endometrial tissue. J Clin Endocrinol Metab 50:541–545, 1980

    • Search Google Scholar
    • Export Citation
  • 5.

    Geier A, , Ginzburg R, & Stauber M, et al: Unoccupied binding sites for oestradiol in nuclei from human breast carcinomatous tissue. J Endocrinol 80:281288, 1979 Geier A, Ginzburg R, Stauber M, et al: Unoccupied binding sites for oestradiol in nuclei from human breast carcinomatous tissue. J Endocrinol 80:281–288, 1979

    • Search Google Scholar
    • Export Citation
  • 6.

    Goffin J: Estrogen- and progesterone-receptors in meningiomas. Clin Neurol Neurosurg 88:169175, 1986 Goffin J: Estrogen- and progesterone-receptors in meningiomas. Clin Neurol Neurosurg 88:169–175, 1986

    • Search Google Scholar
    • Export Citation
  • 7.

    Goodwin W: Tamoxifen in the treatment of refractory meningiomas: a Southwest Oncology Group Study. Proc Annu Meet Am Soc Clin Oncol 6:A270, 1987 (Abstract) Goodwin W: Tamoxifen in the treatment of refractory meningiomas: a Southwest Oncology Group Study. Proc Annu Meet Am Soc Clin Oncol 6:A270, 1987 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 8.

    Grunberg SM, , Daniels AM, & Muensch H, et al: Correlation of meningioma hormone receptor status with hormone sensitivity in a tumor stem-cell assay. J Neurosurg 66:405408, 1987 Grunberg SM, Daniels AM, Muensch H, et al: Correlation of meningioma hormone receptor status with hormone sensitivity in a tumor stem-cell assay. J Neurosurg 66:405–408, 1987

    • Search Google Scholar
    • Export Citation
  • 9.

    Grunberg SM, & Weiss MH: Lack of efficacy of megestrol acetate in the treatment of resectable meningiomas. J Neurooncol 8:6165, 1990 Grunberg SM, Weiss MH: Lack of efficacy of megestrol acetate in the treatment of resectable meningiomas. J Neurooncol 8:61–65, 1990

    • Search Google Scholar
    • Export Citation
  • 10.

    Grunberg SM, , Weiss MH, & Spitz IM, et al: Treatment of unresectable meningiomas with the anti progesterone agent mifepristone. J Neurosurg 74:861866, 1991 Grunberg SM, Weiss MH, Spitz IM, et al: Treatment of unresectable meningiomas with the anti progesterone agent mifepristone. J Neurosurg 74:861–866, 1991

    • Search Google Scholar
    • Export Citation
  • 11.

    Holdaway IM, & Bowditch JV: Variation in receptor status between primary and metastatic breast cancer. Cancer 52:479485, 1983 Holdaway IM, Bowditch JV: Variation in receptor status between primary and metastatic breast cancer. Cancer 52:479–485, 1983

    • Search Google Scholar
    • Export Citation
  • 12.

    Horwitz KB, , Koseki Y, & McGuire WL: Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology 103:17421751, 1978 Horwitz KB, Koseki Y, McGuire WL: Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology 103:1742–1751, 1978

    • Search Google Scholar
    • Export Citation
  • 13.

    Jääskeläinen J, , Laasonen E, & Kärkkäinen J, et al: Hormone treatment of meningiomas: lack of response to medroxyprogesterone acetate (MPA). A pilot study on five cases. Acta Neurochir 80:3541, 1986 Jääskeläinen J, Laasonen E, Kärkkäinen J, et al: Hormone treatment of meningiomas: lack of response to medroxyprogesterone acetate (MPA). A pilot study on five cases. Acta Neurochir 80:35–41, 1986

    • Search Google Scholar
    • Export Citation
  • 14.

    Jensen EV, , Smith S, & deSombre ER: Hormone dependency in breast cancer. J Steroid Biochem 7:911917, 1976 Jensen EV, Smith S, deSombre ER: Hormone dependency in breast cancer. J Steroid Biochem 7:911–917, 1976

    • Search Google Scholar
    • Export Citation
  • 15.

    Lesch KP, & Fahlbusch R: Simultaneous estradiol and progesterone receptor analysis in meningiomas. Surg Neurol 26:257263, 1986 Lesch KP, Fahlbusch R: Simultaneous estradiol and progesterone receptor analysis in meningiomas. Surg Neurol 26:257–263, 1986

    • Search Google Scholar
    • Export Citation
  • 16.

    Lippman M, , Huff K, & Bolan J: Interaction of R5020 with progesterone and glucocorticoids receptors in human breast cancer and peripheral blood lymphocytes in vitro, in McGuire WL, , Raynaud JP, & Baulieru EE (eds): Progesterone Receptors in Normal Neoplastic Tissues. New York: Raven Press, 1977, pp 193210 Lippman M, Huff K, Bolan J: Interaction of R5020 with progesterone and glucocorticoids receptors in human breast cancer and peripheral blood lymphocytes in vitro, in McGuire WL, Raynaud JP, Baulieru EE (eds): Progesterone Receptors in Normal Neoplastic Tissues. New York: Raven Press, 1977, pp 193–210

    • Search Google Scholar
    • Export Citation
  • 17.

    Loven D, , Rakowsky E, & Geier A, et al: A clinical evaluation of nuclear receptors combined with cytosolic estrogen and progesterone receptors in breast cancer. Cancer 66:341346, 1990 Loven D, Rakowsky E, Geier A, et al: A clinical evaluation of nuclear receptors combined with cytosolic estrogen and progesterone receptors in breast cancer. Cancer 66:341–346, 1990

    • Search Google Scholar
    • Export Citation
  • 18.

    Loven D, , Rakowski E, & Stein JA, et al: Hormonal receptors and response to treatment of breast cancer. A retrospective evaluation in 60 patients. Isr J Med Sci 17:960946, 1981 Loven D, Rakowski E, Stein JA, et al: Hormonal receptors and response to treatment of breast cancer. A retrospective evaluation in 60 patients. Isr J Med Sci 17:960–946, 1981

    • Search Google Scholar
    • Export Citation
  • 19.

    Magdelenat H, , Pertuiset BF, & Poisson M, et al: Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases. Acta Neurochir 64:199213, 1982 Magdelenat H, Pertuiset BF, Poisson M, et al: Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases. Acta Neurochir 64:199–213, 1982

    • Search Google Scholar
    • Export Citation
  • 20.

    Markwalder TM, , Seiler RW, & Zava DT: Antiestrogenic therapy of meningiomas — a pilot study. Surg Neurol 24:245249, 1985 Markwalder TM, Seiler RW, Zava DT: Antiestrogenic therapy of meningiomas — a pilot study. Surg Neurol 24:245–249, 1985

    • Search Google Scholar
    • Export Citation
  • 21.

    Markwalder TM, , Zaya DT, & Goldhirsch A, et al: Estrogen and progesterone receptors in meningiomas in relation to clinical and pathologic features. Surg Neurol 20:4247, 1983 Markwalder TM, Zaya DT, Goldhirsch A, et al: Estrogen and progesterone receptors in meningiomas in relation to clinical and pathologic features. Surg Neurol 20:42–47, 1983

    • Search Google Scholar
    • Export Citation
  • 22.

    McCarty KS Jr, , Barton TK, & Fetter BF, et al: Correlation of estrogen and progesterone receptors with histologic differentiation in mammary carcinoma. Cancer 46:28512858, 1980 McCarty KS Jr, Barton TK, Fetter BF, et al: Correlation of estrogen and progesterone receptors with histologic differentiation in mammary carcinoma. Cancer 46:2851–2858, 1980

    • Search Google Scholar
    • Export Citation
  • 23.

    McGuire WL, , Osborne CK, & Clark GM, et al: Steroid hormone receptors and carcinoma of the breast. Am J Physiol 243:E99E102, 1982 McGuire WL, Osborne CK, Clark GM, et al: Steroid hormone receptors and carcinoma of the breast. Am J Physiol 243:E99–E102, 1982

    • Search Google Scholar
    • Export Citation
  • 24.

    Olson JJ, , Beck DW, & Schlechte JA, et al: Effect of the antiprogesterone RU-38484 on meningioma implanted into nude mice. J Neurosurg 66:584587, 1987 Olson JJ, Beck DW, Schlechte JA, et al: Effect of the antiprogesterone RU-38484 on meningioma implanted into nude mice. J Neurosurg 66:584–587, 1987

    • Search Google Scholar
    • Export Citation
  • 25.

    Pichon MF, & Milgrom E: Characterization and assay of progesterone receptor in human mammary carcinoma. Cancer Res 37:464471, 1977 Pichon MF, Milgrom E: Characterization and assay of progesterone receptor in human mammary carcinoma. Cancer Res 37:464–471, 1977

    • Search Google Scholar
    • Export Citation
  • 26.

    Poisson M, , Pertuiset BF, & Hauw JJ, et al: Steroid hormone receptors in human meningiomas, gliomas and brain metastases. J Neurooncol 1:179189, 1983 Poisson M, Pertuiset BF, Hauw JJ, et al: Steroid hormone receptors in human meningiomas, gliomas and brain metastases. J Neurooncol 1:179–189, 1983

    • Search Google Scholar
    • Export Citation
  • 27.

    Rubinstein AB, , Shalit MN, & Cohen ML, et al: Radiationinduced cerebral meningiomas: a recognizable entity. J Neurosurg 61:966971, 1984 Rubinstein AB, Shalit MN, Cohen ML, et al: Radiationinduced cerebral meningiomas: a recognizable entity. J Neurosurg 61:966–971, 1984

    • Search Google Scholar
    • Export Citation
  • 28.

    Salazar OM: Ensuring local control in meningiomas. Int J Radiat Oncol Biol Phys 15:501504, 1988 Salazar OM: Ensuring local control in meningiomas. Int J Radiat Oncol Biol Phys 15:501–504, 1988

    • Search Google Scholar
    • Export Citation
  • 29.

    Schrell UMH, , Adams EF, & Fahlbusch R, et al: Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. J Neurosurg 73:743749, 1990 Schrell UMH, Adams EF, Fahlbusch R, et al: Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. J Neurosurg 73:743–749, 1990

    • Search Google Scholar
    • Export Citation
  • 30.

    Schwartz MR, , Randolph RL, & Cech AD, et al: Steroid hormone binding macromolecules in meningiomas. Failure to meet criteria of specific receptors. Cancer 53:922927, 1984 Schwartz MR, Randolph RL, Cech AD, et al: Steroid hormone binding macromolecules in meningiomas. Failure to meet criteria of specific receptors. Cancer 53:922–927, 1984

    • Search Google Scholar
    • Export Citation
  • 31.

    Trachtenberg J, & Walsh PC: Correlation of prostatic nuclear androgen receptor content with duration of response and survival following hormonal therapy in advanced prostatic cancer. J Urol 127:466471, 1982 Trachtenberg J, Walsh PC: Correlation of prostatic nuclear androgen receptor content with duration of response and survival following hormonal therapy in advanced prostatic cancer. J Urol 127:466–471, 1982

    • Search Google Scholar
    • Export Citation
  • 32.

    Wara WM, , Sheline GE, & Newman H, et al: Radiation therapy of meningiomas. AJR 123:453458, 1975 Wara WM, Sheline GE, Newman H, et al: Radiation therapy of meningiomas. AJR 123:453–458, 1975

    • Search Google Scholar
    • Export Citation

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