Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms

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✓ In patients with spinal cord injury, the primary or mechanical trauma seldom causes total transection, even though the functional loss may be complete. In addition, biochemical and pathological changes in the cord may worsen after injury. To explain these phenomena, the concept of the secondary injury has evolved for which numerous pathophysiological mechanisms have been postulated. This paper reviews the concept of secondary injury with special emphasis on vascular mechanisms. Evidence is presented to support the theory of secondary injury and the hypothesis that a key mechanism is posttraumatic ischemia with resultant infarction of the spinal cord. Evidence for the role of vascular mechanisms has been obtained from a variety of models of acute spinal cord injury in several species. Many different angiographic methods have been used for assessing microcirculation of the cord and for measuring spinal cord blood flow after trauma. With these techniques, the major systemic and local vascular effects of acute spinal cord injury have been identified and implicated in the etiology of secondary injury.

The systemic effects of acute spinal cord injury include hypotension and reduced cardiac output. The local effects include loss of autoregulation in the injured segment of the spinal cord and a marked reduction of the microcirculation in both gray and white matter, especially in hemorrhagic regions and in adjacent zones. The microcirculatory loss extends for a considerable distance proximal and distal to the site of injury. Many studies have shown a dose-dependent reduction of spinal cord blood flow varying with the severity of injury, and a reduction of spinal cord blood flow which worsens with time after injury. The functional deficits due to acute spinal cord injury have been measured electrophysiologically with techniques such as motor and somatosensory evoked potentials and have been found proportional to the degree of posttraumatic ischemia. The histological effects include early hemorrhagic necrosis leading to major infarction at the injury site.

These posttraumatic vascular effects can be treated. Systemic normotension can be restored with volume expansion or vasopressors, and spinal cord blood flow can be improved with dopamine, steroids, nimodipine, or volume expansion. The combination of nimodipine and volume expansion improves posttraumatic spinal cord blood flow and spinal cord function measured by evoked potentials. These results provide strong evidence that posttraumatic ischemia is an important secondary mechanism of injury, and that it can be counteracted.

Article Information

Contributor Notes

Address reprint requests to: Charles H. Tator, M.D., Toronto Western Division, Toronto Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.
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References
  • 1.

    Alderman JLOsterholm JLD'Amore BRet al: Influence of arterial blood pressure upon central hemorrhagic necrosis after severe spinal cord injury. Neurosurgery 4:53551979Alderman JL Osterholm JL D'Amore BR et al: Influence of arterial blood pressure upon central hemorrhagic necrosis after severe spinal cord injury. Neurosurgery 4:53–55 1979

    • Search Google Scholar
    • Export Citation
  • 2.

    Alexander SKerr FWL: Blood pressure responses in acute compression of the spinal cord. J Neurosurg 21:4854911964Alexander S Kerr FWL: Blood pressure responses in acute compression of the spinal cord. J Neurosurg 21:485–491 1964

    • Search Google Scholar
    • Export Citation
  • 3.

    Allen AR: Remarks on the histopathological changes in the spinal cord due to impact. An experimental study. J Nerv Ment Dis 41:1411471914Allen AR: Remarks on the histopathological changes in the spinal cord due to impact. An experimental study. J Nerv Ment Dis 41:141–147 1914

    • Search Google Scholar
    • Export Citation
  • 4.

    Allen AR: Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA 57:8788801911Allen AR: Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA 57:878–880 1911

    • Search Google Scholar
    • Export Citation
  • 5.

    Allen GSAhn HSPreziosi TJet al: Cerebral arterial spasm — a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308:6196241983Allen GS Ahn HS Preziosi TJ et al: Cerebral arterial spasm — a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308:619–624 1983

    • Search Google Scholar
    • Export Citation
  • 6.

    Ames A IIIWright RLKowada Met al: Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 52:4374531968Ames A III Wright RL Kowada M et al: Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 52:437–453 1968

    • Search Google Scholar
    • Export Citation
  • 7.

    Anderson DKMeans EDWaters TR: Spinal cord energy metabolism in normal and postlaminectomy cats. J Neurosurg 52:3873911980Anderson DK Means ED Waters TR: Spinal cord energy metabolism in normal and postlaminectomy cats. J Neurosurg 52:387–391 1980

    • Search Google Scholar
    • Export Citation
  • 8.

    Anderson DKMeans EDWaters TRet al: Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment. J Neurosurg 56:1061131982Anderson DK Means ED Waters TR et al: Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment. J Neurosurg 56:106–113 1982

    • Search Google Scholar
    • Export Citation
  • 9.

    Anderson DKSaunders RDDemediuk Pet al: Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium. Cent Nerv Syst Trauma 2:2572671985Anderson DK Saunders RD Demediuk P et al: Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium. Cent Nerv Syst Trauma 2:257–267 1985

    • Search Google Scholar
    • Export Citation
  • 10.

    Auer LMIto ZSuzuki Aet al: Prevention of symptomatic vasospasm by topically applied nimodipine. Acta Neurochir 63:2973021982Auer LM Ito Z Suzuki A et al: Prevention of symptomatic vasospasm by topically applied nimodipine. Acta Neurochir 63:297–302 1982

    • Search Google Scholar
    • Export Citation
  • 11.

    Balentine JD: Pathology of experimental spinal cord trauma II. Ultrastructure of axons and myelin. Lab Invest 39:2542661978Balentine JD: Pathology of experimental spinal cord trauma II. Ultrastructure of axons and myelin. Lab Invest 39:254–266 1978

    • Search Google Scholar
    • Export Citation
  • 12.

    Banik NLHogan ELHsu CY: Molecular and anatomical correlates of spinal cord injury. Cent Nerv Syst Trauma 2:991071985Banik NL Hogan EL Hsu CY: Molecular and anatomical correlates of spinal cord injury. Cent Nerv Syst Trauma 2:99–107 1985

    • Search Google Scholar
    • Export Citation
  • 13.

    Banik NLHogan ELWhetstine LJet al: Changes in myelin and axonal proteins in CaCl2-induced myelopathy in rat spinal cord. Cent Nerv Syst Trauma 1:1311381984Banik NL Hogan EL Whetstine LJ et al: Changes in myelin and axonal proteins in CaCl2-induced myelopathy in rat spinal cord. Cent Nerv Syst Trauma 1:131–138 1984

    • Search Google Scholar
    • Export Citation
  • 14.

    Benveniste HDreger JSchousboe Aet al: Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:136913741984Benveniste H Dreger J Schousboe A et al: Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369–1374 1984

    • Search Google Scholar
    • Export Citation
  • 15.

    Bingham WGGoldman HFriedman SJet al: Blood flow in normal and injured monkey spinal cord. J Neurosurg 43:1621711975Bingham WG Goldman H Friedman SJ et al: Blood flow in normal and injured monkey spinal cord. J Neurosurg 43:162–171 1975

    • Search Google Scholar
    • Export Citation
  • 16.

    Black PMarkowitz RSFinkelstein SDet al: Experimental spinal cord injury: effect of a calcium channel antagonist (nicardipine). Neurosurgery 22:61661988Black P Markowitz RS Finkelstein SD et al: Experimental spinal cord injury: effect of a calcium channel antagonist (nicardipine). Neurosurgery 22:61–66 1988

    • Search Google Scholar
    • Export Citation
  • 17.

    Black PMarkowitz RSKeller Set al: Naloxone and experimental spinal cord injury: part 1. High dose administration in a static load compression model. Neurosurgery 19:9059081986Black P Markowitz RS Keller S et al: Naloxone and experimental spinal cord injury: part 1. High dose administration in a static load compression model. Neurosurgery 19:905–908 1986

    • Search Google Scholar
    • Export Citation
  • 18.

    Black PMarkowitz RSKeller Set al: Naloxone and experimental spinal cord injury: part 2. Megadose treatment in a dynamic load injury model. Neurosurgery 19:9099131986Black P Markowitz RS Keller S et al: Naloxone and experimental spinal cord injury: part 2. Megadose treatment in a dynamic load injury model. Neurosurgery 19:909–913 1986

    • Search Google Scholar
    • Export Citation
  • 19.

    Blight AR: Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling. Neuroscience 10:5215431983Blight AR: Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling. Neuroscience 10:521–543 1983

    • Search Google Scholar
    • Export Citation
  • 20.

    Bracken MBShepard MJCollins WFet al: A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 322:140514111990Bracken MB Shepard MJ Collins WF et al: A randomized controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 322:1405–1411 1990

    • Search Google Scholar
    • Export Citation
  • 21.

    Braughler JMDuncan LAChase RL: Interaction of lipid peroxidation and calcium in the pathogenesis of neuronal injury. Cent Nerv Syst Trauma 2:2692831985Braughler JM Duncan LA Chase RL: Interaction of lipid peroxidation and calcium in the pathogenesis of neuronal injury. Cent Nerv Syst Trauma 2:269–283 1985

    • Search Google Scholar
    • Export Citation
  • 22.

    Braughler JMPregenzer JFChase RLet al: Novel 12-amino steroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem 262:10438104401987Braughler JM Pregenzer JF Chase RL et al: Novel 12-amino steroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem 262:10438–10440 1987

    • Search Google Scholar
    • Export Citation
  • 23.

    Bresnahan JC: An electron-microscopic analysis of axonal alterations following blunt contusion of the spinal cord of the Rhesus monkey (Macaca Mulatta). J Neurol Sci 37:59821978Bresnahan JC: An electron-microscopic analysis of axonal alterations following blunt contusion of the spinal cord of the Rhesus monkey (Macaca Mulatta). J Neurol Sci 37:59–82 1978

    • Search Google Scholar
    • Export Citation
  • 24.

    Bresnahan JCKing JSMartin GFet al: A neuroanatomical analysis of spinal cord injury in the Rhesus monkey (Macaca Mulatta). J Neurol Sci 28:5215421976Bresnahan JC King JS Martin GF et al: A neuroanatomical analysis of spinal cord injury in the Rhesus monkey (Macaca Mulatta). J Neurol Sci 28:521–542 1976

    • Search Google Scholar
    • Export Citation
  • 25.

    Brisman RKovach RMJohnson DOet al: Pulmonary edema in acute transection of the cervical spinal cord. Surg Gynecol Obstet 139:3633661974Brisman R Kovach RM Johnson DO et al: Pulmonary edema in acute transection of the cervical spinal cord. Surg Gynecol Obstet 139:363–366 1974

    • Search Google Scholar
    • Export Citation
  • 26.

    Brodkey JSRichards DEBlasingame JPet al: Reversible spinal cord trauma in cats. Additive effects of direct pressure and ischemia. J Neurosurg 37:5915931972Brodkey JS Richards DE Blasingame JP et al: Reversible spinal cord trauma in cats. Additive effects of direct pressure and ischemia. J Neurosurg 37:591–593 1972

    • Search Google Scholar
    • Export Citation
  • 27.

    Chehrazi BBScremin ODecima EE: Effect of regional spinal cord blood flow and central control in recovery from spinal cord injury. J Neurosurg 71:7477531989Chehrazi BB Scremin O Decima EE: Effect of regional spinal cord blood flow and central control in recovery from spinal cord injury. J Neurosurg 71:747–753 1989

    • Search Google Scholar
    • Export Citation
  • 28.

    Cheung JYBonventre JVMalis CDet al: Calcium and ischemic injury. N Engl J Med 314:167016761986Cheung JY Bonventre JV Malis CD et al: Calcium and ischemic injury. N Engl J Med 314:1670–1676 1986

    • Search Google Scholar
    • Export Citation
  • 29.

    Collins WF: A review and update of experimental and clinical studies of spinal cord injury. Paraplegia 21:2042191983Collins WF: A review and update of experimental and clinical studies of spinal cord injury. Paraplegia 21:204–219 1983

    • Search Google Scholar
    • Export Citation
  • 30.

    De la Torre JC: Spinal cord injury. Review of basic and applied research. Spine 6:3153351981De la Torre JC: Spinal cord injury. Review of basic and applied research. Spine 6:315–335 1981

    • Search Google Scholar
    • Export Citation
  • 31.

    Dohrmann GJWagner FC JrBucy PC: The microvasculature in transitory traumatic paraplegia. An electron microscopic study in the monkey. J Neurosurg 35:2632711971Dohrmann GJ Wagner FC Bucy PC: The microvasculature in transitory traumatic paraplegia. An electron microscopic study in the monkey. J Neurosurg 35:263–271 1971

    • Search Google Scholar
    • Export Citation
  • 32.

    Dolan EJTator CH: The effect of blood transfusion, dopamine, and gamma hydroxybutyrate on posttraumatic ischemia of the spinal cord. J Neurosurg 56:3503581982Dolan EJ Tator CH: The effect of blood transfusion dopamine and gamma hydroxybutyrate on posttraumatic ischemia of the spinal cord. J Neurosurg 56:350–358 1982

    • Search Google Scholar
    • Export Citation
  • 33.

    Dolan EJTator CH: The treatment of hypotension due to acute experimental spinal cord compression injury. Surg Neurol 13:3803841980Dolan EJ Tator CH: The treatment of hypotension due to acute experimental spinal cord compression injury. Surg Neurol 13:380–384 1980

    • Search Google Scholar
    • Export Citation
  • 34.

    Dolan EJTransfeldt EETator CH: The effect of spinal distraction on regional spinal cord blood flow in cats. J Neurosurg 53:7567641980Dolan EJ Transfeldt EE Tator CH: The effect of spinal distraction on regional spinal cord blood flow in cats. J Neurosurg 53:756–764 1980

    • Search Google Scholar
    • Export Citation
  • 35.

    Doppman JLGirton MPopovsky MA: Acute occlusion of the posterior spinal vein. Experimental study in monkeys. J Neurosurg 51:2012051979Doppman JL Girton M Popovsky MA: Acute occlusion of the posterior spinal vein. Experimental study in monkeys. J Neurosurg 51:201–205 1979

    • Search Google Scholar
    • Export Citation
  • 36.

    Ducker TBHamit HF: Experimental treatments of acute spinal cord injury. J Neurosurg 30:6936971969Ducker TB Hamit HF: Experimental treatments of acute spinal cord injury. J Neurosurg 30:693–697 1969

    • Search Google Scholar
    • Export Citation
  • 37.

    Ducker TBKindt GWKempe LG: Pathological findings in acute experimental spinal cord trauma. J Neurosurg 35:7007081971Ducker TB Kindt GW Kempe LG: Pathological findings in acute experimental spinal cord trauma. J Neurosurg 35:700–708 1971

    • Search Google Scholar
    • Export Citation
  • 38.

    Ducker TBPerot PL Jr: Local tissue oxygen and blood flow in the acutely injured spinal cord. Proc Veterans Admin Spinal Cord In Conf 18:29321971Ducker TB Perot PL Jr: Local tissue oxygen and blood flow in the acutely injured spinal cord. Proc Veterans Admin Spinal Cord In Conf 18:29–32 1971

    • Search Google Scholar
    • Export Citation
  • 39.

    Duverger DBenavides JCudennec Aet al: A glutamate antagonist reduces infarction size following focal cerebral ischaemia independently of vascular and metabolic changes. J Cereb Blood Flow Metab 7 (Suppl):1441987 (Abstract)Duverger D Benavides J Cudennec A et al: A glutamate antagonist reduces infarction size following focal cerebral ischaemia independently of vascular and metabolic changes. J Cereb Blood Flow Metab 7 (Suppl): 144 1987 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 40.

    Faden AIJacobs TP: Effect of TRH analogs on neurologic recovery after experimental spinal trauma. Neurology 35:133113341985Faden AI Jacobs TP: Effect of TRH analogs on neurologic recovery after experimental spinal trauma. Neurology 35:1331–1334 1985

    • Search Google Scholar
    • Export Citation
  • 41.

    Faden AIJacobs TPHoladay JW: Comparison of early and late naloxone treatment in experimental spinal injury. Neurology 32:6776811982Faden AI Jacobs TP Holaday JW: Comparison of early and late naloxone treatment in experimental spinal injury. Neurology 32:677–681 1982

    • Search Google Scholar
    • Export Citation
  • 42.

    Faden AIJacobs TPMougey Eet al: Endorphins in experimental spinal cord injury: therapeutic effect of aloxone. Ann Neurol 10:3263321981Faden AI Jacobs TP Mougey E et al: Endorphins in experimental spinal cord injury: therapeutic effect of aloxone. Ann Neurol 10:326–332 1981

    • Search Google Scholar
    • Export Citation
  • 43.

    Faden AIJacobs TPSmith MT: Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia. J Neurosurg 60:7967991984Faden AI Jacobs TP Smith MT: Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia. J Neurosurg 60:796–799 1984

    • Search Google Scholar
    • Export Citation
  • 44.

    Faden AISimon RP: A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann Neurol 23:6236261988Faden AI Simon RP: A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann Neurol 23:623–626 1988

    • Search Google Scholar
    • Export Citation
  • 45.

    Fairholm DJTurnbull IM: Microangiographic study of experimental spinal cord injuries. J Neurosurg 35:2772861971Fairholm DJ Turnbull IM: Microangiographic study of experimental spinal cord injuries. J Neurosurg 35:277–286 1971

    • Search Google Scholar
    • Export Citation
  • 46.

    Fehlings MGTator CH: A review of experimental models of acute spinal cord injury in Illis L (ed): Spinal Cord Dysfunction: Assessment. New York: Oxford University Press1988 pp 333Fehlings MG Tator CH: A review of experimental models of acute spinal cord injury in Illis L (ed): Spinal Cord Dysfunction: Assessment. New York: Oxford University Press 1988 pp 3–33

    • Search Google Scholar
    • Export Citation
  • 47.

    Fehlings MGTator CHLinden RD: The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg 71:4034161989Fehlings MG Tator CH Linden RD: The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg 71:403–416 1989

    • Search Google Scholar
    • Export Citation
  • 48.

    Fehlings MGTator CHLinden RD: The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow. Electroencephalogr Clin Neurophysiol 74:2412591989Fehlings MG Tator CH Linden RD: The relationships among the severity of spinal cord injury motor and somatosensory evoked potentials and spinal cord blood flow. Electroencephalogr Clin Neurophysiol 74:241–259 1989

    • Search Google Scholar
    • Export Citation
  • 49.

    Fischer EGAmes A IIIHedley-Whyte ETet al: Reassessment of cerebral capillary changes in acute global ischemia and their relationship to the “no-reflow phenomenon.” Stroke 8:36391977Fischer EG Ames A III Hedley-Whyte ET et al: Reassessment of cerebral capillary changes in acute global ischemia and their relationship to the “no-reflow phenomenon.” Stroke 8:36–39 1977

    • Search Google Scholar
    • Export Citation
  • 50.

    Flamm ESYoung WDemopoulos HB: Experimental spinal cord injury. Treatment with naloxone. Neurosurgery 10:2272311982Flamm ES Young W Demopoulos HB: Experimental spinal cord injury. Treatment with naloxone. Neurosurgery 10:227–231 1982

    • Search Google Scholar
    • Export Citation
  • 51.

    Ford RWMalm DN: Failure of nimodipine to reverse acute experimental spinal cord injury. Cent Nerv Syst Trauma 2:9171985Ford RW Malm DN: Failure of nimodipine to reverse acute experimental spinal cord injury. Cent Nerv Syst Trauma 2:9–17 1985

    • Search Google Scholar
    • Export Citation
  • 52.

    Fried LCGoodkin R: Microangiographic observations of the experimentally traumatized spinal cord. J Neurosurg 35:7097141971Fried LC Goodkin R: Microangiographic observations of the experimentally traumatized spinal cord. J Neurosurg 35:709–714 1971

    • Search Google Scholar
    • Export Citation
  • 53.

    Gelmers HJ: Nimodipine, a new calcium antagonist in the prophylactic treatment of migraine. Headache 23:1061091983Gelmers HJ: Nimodipine a new calcium antagonist in the prophylactic treatment of migraine. Headache 23:106–109 1983

    • Search Google Scholar
    • Export Citation
  • 54.

    Germano IMBartkowski HMCassel MEet al: The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histological findings. J Neurosurg 67:81871987Germano IM Bartkowski HM Cassel ME et al: The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histological findings. J Neurosurg 67:81–87 1987

    • Search Google Scholar
    • Export Citation
  • 55.

    Greenhoot JHOshiel FOMauck HP: Experimental spinal cord injury. Electrocardiographic abnormalities and fuchsinophilic myocardial degeneration. Arch Neurol 26:5245291972Greenhoot JH Oshiel FO Mauck HP: Experimental spinal cord injury. Electrocardiographic abnormalities and fuchsinophilic myocardial degeneration. Arch Neurol 26:524–529 1972

    • Search Google Scholar
    • Export Citation
  • 56.

    Griffiths IR: Spinal cord blood flow after acute experimental cord injury in dogs. J Neurol Sci 27:2472591976Griffiths IR: Spinal cord blood flow after acute experimental cord injury in dogs. J Neurol Sci 27:247–259 1976

    • Search Google Scholar
    • Export Citation
  • 57.

    Griffiths IR: Spinal cord blood flow in dogs: 1. The effect of blood pressure. J Neurol Neurosurg Psychiatry 36:9149201973Griffiths IR: Spinal cord blood flow in dogs: 1. The effect of blood pressure. J Neurol Neurosurg Psychiatry 36:914–920 1973

    • Search Google Scholar
    • Export Citation
  • 58.

    Griffiths IR: Spinal cord blood flow in dogs: 2. The effect of the blood gases. J Neurol Neurosurg Psychiatry 36:42491973Griffiths IR: Spinal cord blood flow in dogs: 2. The effect of the blood gases. J Neurol Neurosurg Psychiatry 36:42–49 1973

    • Search Google Scholar
    • Export Citation
  • 59.

    Griffiths IRMcCulloch MC: Nerve fibers in spinal cord impact injuries. Part 1. Changes in the myelin sheath during the initial five weeks. J Neurol Sci 58:3353491983Griffiths IR McCulloch MC: Nerve fibers in spinal cord impact injuries. Part 1. Changes in the myelin sheath during the initial five weeks. J Neurol Sci 58:335–349 1983

    • Search Google Scholar
    • Export Citation
  • 60.

    Guha ATator CH: Acute cardiovascular effects of experimental spinal cord injury. J Trauma 28:4814901988Guha A Tator CH: Acute cardiovascular effects of experimental spinal cord injury. J Trauma 28:481–490 1988

    • Search Google Scholar
    • Export Citation
  • 61.

    Guha ATator CHPiper I: Effect of a calcium channel blocker on posttraumatic spinal cord blood flow. J Neurosurg 66:4234301987Guha A Tator CH Piper I: Effect of a calcium channel blocker on posttraumatic spinal cord blood flow. J Neurosurg 66:423–430 1987

    • Search Google Scholar
    • Export Citation
  • 62.

    Guha ATator CHPiper I: Increase in rat spinal cord blood flow with the calcium channel blocker, nimodipine. J Neurosurg 63:2502591985Guha A Tator CH Piper I: Increase in rat spinal cord blood flow with the calcium channel blocker nimodipine. J Neurosurg 63:250–259 1985

    • Search Google Scholar
    • Export Citation
  • 63.

    Guha ATator CHRochon J: Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats. Stroke 20:3723771989Guha A Tator CH Rochon J: Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats. Stroke 20:372–377 1989

    • Search Google Scholar
    • Export Citation
  • 64.

    Guha ATator CHSmith CRet al: Improvement in post-traumatic spinal cord blood flow with a combination of a calcium channel blocker and a vasopressor. J Trauma 29:144014471989Guha A Tator CH Smith CR et al: Improvement in post-traumatic spinal cord blood flow with a combination of a calcium channel blocker and a vasopressor. J Trauma 29:1440–1447 1989

    • Search Google Scholar
    • Export Citation
  • 65.

    Haghighi SSChehrazi B: Effect of naloxone in experimental acute spinal cord injury. Neurosurgery 20:3853881987Haghighi SS Chehrazi B: Effect of naloxone in experimental acute spinal cord injury. Neurosurgery 20:385–388 1987

    • Search Google Scholar
    • Export Citation
  • 66.

    Hall ED: Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats. J Neurosurg 68:4624651988Hall ED: Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats. J Neurosurg 68:462–465 1988

    • Search Google Scholar
    • Export Citation
  • 67.

    Hall EDWolf DL: A pharmacological analysis of the pathophysiologic mechanisms of posttraumatic spinal cord ischemia. J Neurosurg 64:9519611986Hall ED Wolf DL: A pharmacological analysis of the pathophysiologic mechanisms of posttraumatic spinal cord ischemia. J Neurosurg 64:951–961 1986

    • Search Google Scholar
    • Export Citation
  • 68.

    Hall EDWolf DLBraughler JM: Effects of a single large dose of methylprednisolone sodium succinate on experimental posttraumatic spinal cord ischemia. Dose-response and time-action analysis. J Neurosurg 61:1241301984Hall ED Wolf DL Braughler JM: Effects of a single large dose of methylprednisolone sodium succinate on experimental posttraumatic spinal cord ischemia. Dose-response and time-action analysis. J Neurosurg 61:124–130 1984

    • Search Google Scholar
    • Export Citation
  • 69.

    Hall EDYonkers PAHoran KL: Correlation between attenuation of posttraumatic spinal cord ischemia and preservation of tissue vitamin E by the 21-aminosteroid u74006F: evidence for an in vivo antioxidant mechanism. J Neurotrauma 6:1691761989Hall ED Yonkers PA Horan KL: Correlation between attenuation of posttraumatic spinal cord ischemia and preservation of tissue vitamin E by the 21-aminosteroid u74006F: evidence for an in vivo antioxidant mechanism. J Neurotrauma 6:169–176 1989

    • Search Google Scholar
    • Export Citation
  • 70.

    Happel RDSmith KPBanik NLet al: Ca2+ accumulation in experimental spinal cord trauma. Brain Res 211:4764791981Happel RD Smith KP Banik NL et al: Ca2+ accumulation in experimental spinal cord trauma. Brain Res 211:476–479 1981

    • Search Google Scholar
    • Export Citation
  • 71.

    Hardy RWBrodkey JSRichards DEet al: Effect of systemic hypertension on compression block of spinal cord. Surg Forum 23:4344351972Hardy RW Brodkey JS Richards DE et al: Effect of systemic hypertension on compression block of spinal cord. Surg Forum 23:434–435 1972

    • Search Google Scholar
    • Export Citation
  • 72.

    Harper AMCraigen LKazda S: Effect of the calcium antagonist, nimodipine, on cerebral blood flow and metabolism in the primate. J Cereb Blood Flow Metab 1:3493561981Harper AM Craigen L Kazda S: Effect of the calcium antagonist nimodipine on cerebral blood flow and metabolism in the primate. J Cereb Blood Flow Metab 1:349–356 1981

    • Search Google Scholar
    • Export Citation
  • 73.

    Hogan ELHsu CYBanik NL: Calcium-activated mediators of secondary injury in the spinal cord. Cent Nerv Syst Trauma 3:1751791986Hogan EL Hsu CY Banik NL: Calcium-activated mediators of secondary injury in the spinal cord. Cent Nerv Syst Trauma 3:175–179 1986

    • Search Google Scholar
    • Export Citation
  • 74.

    Holtz ANyström BGerdin B: Spinal cord injury in rats: inability of nimodipine or anti-neutrophil serum to improve spinal cord blood flow or neurologic status. Acta Neurol Scand 79:4604671989Holtz A Nyström B Gerdin B: Spinal cord injury in rats: inability of nimodipine or anti-neutrophil serum to improve spinal cord blood flow or neurologic status. Acta Neurol Scand 79:460–467 1989

    • Search Google Scholar
    • Export Citation
  • 75.

    Hubschmann ORNathanson DC: The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage. J Neurosurg 62:6987031985Hubschmann OR Nathanson DC: The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage. J Neurosurg 62:698–703 1985

    • Search Google Scholar
    • Export Citation
  • 76.

    Jørgensen MBDiemer NH: Selective neuron loss after cerebral ischemia in the rat: possible role of transmitter glutamate. Acta Neurol Scand 66:5365461982Jørgensen MB Diemer NH: Selective neuron loss after cerebral ischemia in the rat: possible role of transmitter glutamate. Acta Neurol Scand 66:536–546 1982

    • Search Google Scholar
    • Export Citation
  • 77.

    Kaieda RTodd MMCook LNet al: Acute effects of changing plasma osmolality and colloid oncotic pressure on the formation of brain edema after cryogenic injury. Neurosurgery 24:6716781989Kaieda R Todd MM Cook LN et al: Acute effects of changing plasma osmolality and colloid oncotic pressure on the formation of brain edema after cryogenic injury. Neurosurgery 24:671–678 1989

    • Search Google Scholar
    • Export Citation
  • 78.

    Kakulas BA: Pathology of spinal injuries. Cent Nerv Syst Trauma 1:1171291984Kakulas BA: Pathology of spinal injuries. Cent Nerv Syst Trauma 1:117–129 1984

    • Search Google Scholar
    • Export Citation
  • 79.

    Khan MGriebel R: Acute spinal cord injury in the rat: comparison of three experimental techniques. Can J Neurol Sci 10:1611651983Khan M Griebel R: Acute spinal cord injury in the rat: comparison of three experimental techniques. Can J Neurol Sci 10:161–165 1983

    • Search Google Scholar
    • Export Citation
  • 80.

    Khan MGriebel RRozdilsky Bet al: Hemorrhagic changes in experimental spinal cord injury models. Can J Neurol Sci 12:2592621985Khan M Griebel R Rozdilsky B et al: Hemorrhagic changes in experimental spinal cord injury models. Can J Neurol Sci 12:259–262 1985

    • Search Google Scholar
    • Export Citation
  • 81.

    Kobrine AIDoyle TFMartins AN: Local spinal cord blood flow in experimental traumatic myelopathy. J Neurosurg 42:1441491975Kobrine AI Doyle TF Martins AN: Local spinal cord blood flow in experimental traumatic myelopathy. J Neurosurg 42:144–149 1975

    • Search Google Scholar
    • Export Citation
  • 82.

    Kobrine AIDoyle TFRizzoli HV: Spinal cord blood flow as affected by changes in systemic arterial blood pressure. J Neurosurg 44:12151976Kobrine AI Doyle TF Rizzoli HV: Spinal cord blood flow as affected by changes in systemic arterial blood pressure. J Neurosurg 44:12–15 1976

    • Search Google Scholar
    • Export Citation
  • 83.

    Kobrine AIEvans DERizzoli HV: The effects of ischemia on long-tract neural conduction in the spinal cord. J Neurosurg 50:6396441979Kobrine AI Evans DE Rizzoli HV: The effects of ischemia on long-tract neural conduction in the spinal cord. J Neurosurg 50:639–644 1979

    • Search Google Scholar
    • Export Citation
  • 84.

    Korosue KHeros RCOgilvy CSet al: Comparison of crystalloids and colloids for hemodilution in a model of focal cerebral ischemia. J Neurosurg 73:5765841990Korosue K Heros RC Ogilvy CS et al: Comparison of crystalloids and colloids for hemodilution in a model of focal cerebral ischemia. J Neurosurg 73:576–584 1990

    • Search Google Scholar
    • Export Citation
  • 85.

    Kraus JFFranti CERiggins RS: Incidence of traumatic spinal cord lesions. J Chronic Dis 28:4714921975Kraus JF Franti CE Riggins RS: Incidence of traumatic spinal cord lesions. J Chronic Dis 28:471–492 1975

    • Search Google Scholar
    • Export Citation
  • 86.

    Kwo SYoung WDe Crescito V: Spinal cord sodium, potassium, calcium, and water concentration changes in rats after graded contusion injury. J Neurotrauma 6:13241989Kwo S Young W De Crescito V: Spinal cord sodium potassium calcium and water concentration changes in rats after graded contusion injury. J Neurotrauma 6:13–24 1989

    • Search Google Scholar
    • Export Citation
  • 87.

    Leslie JBWatkins WD: Eicosanoids in the central nervous system. Review article. J Neurosurg 63:6596681985Leslie JB Watkins WD: Eicosanoids in the central nervous system. Review article. J Neurosurg 63:659–668 1985

    • Search Google Scholar
    • Export Citation
  • 88.

    Mabe HNagai HTakagi T: Effect of nimodipine on cerebral function and metabolic recovery following ischemia in the rat brain. Stroke 17:5015051986Mabe H Nagai H Takagi T: Effect of nimodipine on cerebral function and metabolic recovery following ischemia in the rat brain. Stroke 17:501–505 1986

    • Search Google Scholar
    • Export Citation
  • 89.

    Mayer MLWestbrook GL: Cellular mechanisms underlying excitotoxicity. Trends Neurosci 10:59611987Mayer ML Westbrook GL: Cellular mechanisms underlying excitotoxicity. Trends Neurosci 10:59–61 1987

    • Search Google Scholar
    • Export Citation
  • 90.

    Mayer MLWestbrook GL: The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neurobiol 28:1972761987Mayer ML Westbrook GL: The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neurobiol 28:197–276 1987

    • Search Google Scholar
    • Export Citation
  • 91.

    Meldrum B: Excitatory amino acids and anoxic/ischemic brain damage. Trends Neurosci 8:47481985Meldrum B: Excitatory amino acids and anoxic/ischemic brain damage. Trends Neurosci 8:47–48 1985

    • Search Google Scholar
    • Export Citation
  • 92.

    Mohamed AAMcCulloch JMendelow ADet al: Effect of the calcium antagonist nimodipine on local cerebral blood flow: relationship to arterial pressure. J Cereb Blood Flow Metab 4:2062111984Mohamed AA McCulloch J Mendelow AD et al: Effect of the calcium antagonist nimodipine on local cerebral blood flow: relationship to arterial pressure. J Cereb Blood Flow Metab 4:206–211 1984

    • Search Google Scholar
    • Export Citation
  • 93.

    Nemecek S: Morphological evidence of microcirculatory disturbances in experimental spinal cord trauma. Adv Neurol 20:3954051978Nemecek S: Morphological evidence of microcirculatory disturbances in experimental spinal cord trauma. Adv Neurol 20:395–405 1978

    • Search Google Scholar
    • Export Citation
  • 94.

    Nowicki JPMackenzie ETYoung AR: Brain ischaemia, calcium and calcium antagonists. Pathol Biol (Paris) 30:2822881982Nowicki JP Mackenzie ET Young AR: Brain ischaemia calcium and calcium antagonists. Pathol Biol (Paris) 30:282–288 1982

    • Search Google Scholar
    • Export Citation
  • 95.

    Osterholm JLMathews GJ: Altered norepinephrine metabolism following experimental spinal cord injury. Part I: Relationship to hemorrhagic necrosis and postwounding neurological deficits. J Neurosurg 36:3863941972Osterholm JL Mathews GJ: Altered norepinephrine metabolism following experimental spinal cord injury. Part I: Relationship to hemorrhagic necrosis and postwounding neurological deficits. J Neurosurg 36:386–394 1972

    • Search Google Scholar
    • Export Citation
  • 96.

    Osterholm JLMathews GJ: Altered norepinephrine metabolism following experimental spinal cord injury. Part 2: Protection against traumatic spinal cord hemorrhagic necrosis by norepinephrine synthesis blockade with alpha methyl tyrosine. J Neurosurg 36:3954011972Osterholm JL Mathews GJ: Altered norepinephrine metabolism following experimental spinal cord injury. Part 2: Protection against traumatic spinal cord hemorrhagic necrosis by norepinephrine synthesis blockade with alpha methyl tyrosine. J Neurosurg 36:395–401 1972

    • Search Google Scholar
    • Export Citation
  • 97.

    Petruck KCWest MMohr Get al: Nimodipine treatment in poor-grade aneurysm patients. Results of a multicenter double-blind placebo-controlled study. J Neurosurg 68:5055171988Petruck KC West M Mohr G et al: Nimodipine treatment in poor-grade aneurysm patients. Results of a multicenter double-blind placebo-controlled study. J Neurosurg 68:505–517 1988

    • Search Google Scholar
    • Export Citation
  • 98.

    Pickard JDMurray GDIllingworth Ret al: Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British Aneurysm Nimodipine Trial. Br Med J 298:6366421989Pickard JD Murray GD Illingworth R et al: Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British Aneurysm Nimodipine Trial. Br Med J 298:636–642 1989

    • Search Google Scholar
    • Export Citation
  • 99.

    Piper IGuha ATator CHet al: A microcomputer system for on-line collection of blood flow and related physiological data. Comput Biol Med 4:2792911987Piper I Guha A Tator CH et al: A microcomputer system for on-line collection of blood flow and related physiological data. Comput Biol Med 4:279–291 1987

    • Search Google Scholar
    • Export Citation
  • 100.

    Rawe SELee WAPerot PL Jr: The histopathology of experimental spinal cord trauma. The effect of systemic blood pressure. J Neurosurg 48:100210071978Rawe SE Lee WA Perot PL Jr: The histopathology of experimental spinal cord trauma. The effect of systemic blood pressure. J Neurosurg 48:1002–1007 1978

    • Search Google Scholar
    • Export Citation
  • 101.

    Rawe SEPerot PL: Pressor response resulting from experimental contusion injury to the spinal cord. J Neurosurg 50:58631979Rawe SE Perot PL: Pressor response resulting from experimental contusion injury to the spinal cord. J Neurosurg 50:58–63 1979

    • Search Google Scholar
    • Export Citation
  • 102.

    Rawe SERoth RHCollins WF: Norepinephrine levels in experimental spinal cord trauma. Part 2. Histopathological study of hemorrhagic necrosis. J Neurosurg 46:3503571977Rawe SE Roth RH Collins WF: Norepinephrine levels in experimental spinal cord trauma. Part 2. Histopathological study of hemorrhagic necrosis. J Neurosurg 46:350–357 1977

    • Search Google Scholar
    • Export Citation
  • 103.

    Rivlin ASTator CH: Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:39431978Rivlin AS Tator CH: Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:39–43 1978

    • Search Google Scholar
    • Export Citation
  • 104.

    Rivlin ASTator CH: Regional spinal cord blood flow in rats after severe cord trauma. J Neurosurg 49:8448531978Rivlin AS Tator CH: Regional spinal cord blood flow in rats after severe cord trauma. J Neurosurg 49:844–853 1978

    • Search Google Scholar
    • Export Citation
  • 105.

    Rothman SMOlney JW: Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19:1051111986Rothman SM Olney JW: Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19:105–111 1986

    • Search Google Scholar
    • Export Citation
  • 106.

    Sandler ANTator CH: Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates. J Neurosurg 45:6606761976Sandler AN Tator CH: Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates. J Neurosurg 45:660–676 1976

    • Search Google Scholar
    • Export Citation
  • 107.

    Sandler ANTator CH: Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord. J Neurosurg 45:6386461976Sandler AN Tator CH: Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord. J Neurosurg 45:638–646 1976

    • Search Google Scholar
    • Export Citation
  • 108.

    Schanne FAXKane ABYoung EEet al: Calcium dependence of toxic cell death: a final common pathway. Science 206:7007021979Schanne FAX Kane AB Young EE et al: Calcium dependence of toxic cell death: a final common pathway. Science 206:700–702 1979

    • Search Google Scholar
    • Export Citation
  • 109.

    Schlaepfer WW: Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve. Brain Res 69:2032151974Schlaepfer WW: Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve. Brain Res 69:203–215 1974

    • Search Google Scholar
    • Export Citation
  • 110.

    Schlaepfer WWBunge RP: Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture. J Cell Biol 59:4564701973Schlaepfer WW Bunge RP: Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture. J Cell Biol 59:456–470 1973

    • Search Google Scholar
    • Export Citation
  • 111.

    Schlaepfer WWHasler MB: Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve. Brain Res 168:2993091979Schlaepfer WW Hasler MB: Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve. Brain Res 168:299–309 1979

    • Search Google Scholar
    • Export Citation
  • 112.

    Scriabine ABattye RHohmeister F: New drugs annual: cardiovascular drugs in Scriabine A (ed): Nimodipine. New York: Raven Press1985 pp 197218Scriabine A Battye R Hohmeister F: New drugs annual: cardiovascular drugs in Scriabine A (ed): Nimodipine. New York: Raven Press 1985 pp 197–218

    • Search Google Scholar
    • Export Citation
  • 113.

    Senter HJVenes JL: Altered blood flow and secondary injury in experimental spinal cord trauma. J Neurosurg 49:5695781978Senter HJ Venes JL: Altered blood flow and secondary injury in experimental spinal cord trauma. J Neurosurg 49:569–578 1978

    • Search Google Scholar
    • Export Citation
  • 114.

    Senter HJVenes JL: Loss of autoregulation and posttraumatic ischemia following experimental spinal cord trauma. J Neurosurg 50:1982061979Senter HJ Venes JL: Loss of autoregulation and posttraumatic ischemia following experimental spinal cord trauma. J Neurosurg 50:198–206 1979

    • Search Google Scholar
    • Export Citation
  • 115.

    Simon RPSwan JHGriffiths Jet al: Blocked N-methyl-D-aspartate receptors may protect against ischemia damage in the brain. Science 226:8508521984Simon RP Swan JH Griffiths J et al: Blocked N-methyl-D-aspartate receptors may protect against ischemia damage in the brain. Science 226:850–852 1984

    • Search Google Scholar
    • Export Citation
  • 116.

    Somerson SKStokes BT: Functional analysis of an electromechanical spinal cord injury device. Exp Neurol 96:82961987Somerson SK Stokes BT: Functional analysis of an electromechanical spinal cord injury device. Exp Neurol 96:82–96 1987

    • Search Google Scholar
    • Export Citation
  • 117.

    Steen PANewberg LAMilde JHet al: Nimodipine improves cerebral blood flow and neurologic recovery after complete cerebral ischemia in the dog. J Cereb Blood Flow Metab 3:38431983Steen PA Newberg LA Milde JH et al: Nimodipine improves cerebral blood flow and neurologic recovery after complete cerebral ischemia in the dog. J Cereb Blood Flow Metab 3:38–43 1983

    • Search Google Scholar
    • Export Citation
  • 118.

    Stokes BTFox PHollinden G: Extracellular calcium activity in the injured spinal cord. Exp Neurol 80:5615721983Stokes BT Fox P Hollinden G: Extracellular calcium activity in the injured spinal cord. Exp Neurol 80:561–572 1983

    • Search Google Scholar
    • Export Citation
  • 119.

    Sundt TM JrGrant WCGarcia HJ: Restoration of middle cerebral artery flow in experimental infarction. J Neurosurg 31:3113221969Sundt TM Jr Grant WC Garcia HJ: Restoration of middle cerebral artery flow in experimental infarction. J Neurosurg 31:311–322 1969

    • Search Google Scholar
    • Export Citation
  • 120.

    Tator CH: Acute management of spinal cord injury. Br J Surg 77:4854861990Tator CH: Acute management of spinal cord injury. Br J Surg 77:485–486 1990

    • Search Google Scholar
    • Export Citation
  • 121.

    Tator CH: Spine-spinal cord relationships in spinal cord trauma. Clin Neurosurg 30:4794941983Tator CH: Spine-spinal cord relationships in spinal cord trauma. Clin Neurosurg 30:479–494 1983

    • Search Google Scholar
    • Export Citation
  • 122.

    Tator CHEdmonds VE: Acute spinal cord injury: analysis of epidemiological factors. Can J Surg 22:5755781979Tator CH Edmonds VE: Acute spinal cord injury: analysis of epidemiological factors. Can J Surg 22:575–578 1979

    • Search Google Scholar
    • Export Citation
  • 123.

    Tator CHRowed DW: Current concepts in the immediate management of acute spinal cord injuries. Can Med Assoc J 121:145314641979Tator CH Rowed DW: Current concepts in the immediate management of acute spinal cord injuries. Can Med Assoc J 121:1453–1464 1979

    • Search Google Scholar
    • Export Citation
  • 124.

    Tator CHRowed DWSchwartz MLet al: Management of acute spinal cord injuries. Can J Surg 27:2892941984Tator CH Rowed DW Schwartz ML et al: Management of acute spinal cord injuries. Can J Surg 27:289–294 1984

    • Search Google Scholar
    • Export Citation
  • 125.

    Tibbs PAYoung BTodd EPet al: Studies of experimental cervical spinal cord transection. Part IV: Effects of cervical spinal cord transection on myocardial blood flow in anesthetized dogs. J Neurosurg 52:1972021980Tibbs PA Young B Todd EP et al: Studies of experimental cervical spinal cord transection. Part IV: Effects of cervical spinal cord transection on myocardial blood flow in anesthetized dogs. J Neurosurg 52:197–202 1980

    • Search Google Scholar
    • Export Citation
  • 126.

    Voldby BPetersen OFBuhl Met al: Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine). An experimental study. Acta Neurochir 70:2432541984Voldby B Petersen OF Buhl M et al: Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine). An experimental study. Acta Neurochir 70:243–254 1984

    • Search Google Scholar
    • Export Citation
  • 127.

    Wagner FC JrStewart WB: Effect of trauma dose on spinal cord edema. J Neurosurg 54:8028061981Wagner FC Jr Stewart WB: Effect of trauma dose on spinal cord edema. J Neurosurg 54:802–806 1981

    • Search Google Scholar
    • Export Citation
  • 128.

    Wallace MCTator CH: Failure of blood transfusion or naloxone to improve clinical recovery after experimental spinal cord injury. Neurosurgery 19:4894941986Wallace MC Tator CH: Failure of blood transfusion or naloxone to improve clinical recovery after experimental spinal cord injury. Neurosurgery 19:489–494 1986

    • Search Google Scholar
    • Export Citation
  • 129.

    Wallace MCTator CH: Failure of naloxone to improve spinal cord blood flow and cardiac output after spinal cord injury. Neurosurgery 18:4284321986Wallace MC Tator CH: Failure of naloxone to improve spinal cord blood flow and cardiac output after spinal cord injury. Neurosurgery 18:428–432 1986

    • Search Google Scholar
    • Export Citation
  • 130.

    Wallace MCTator CH: Spinal cord blood flow measured with microspheres following spinal cord injury in the rat. Can J Neurol Sci 13:91961986Wallace MC Tator CH: Spinal cord blood flow measured with microspheres following spinal cord injury in the rat. Can J Neurol Sci 13:91–96 1986

    • Search Google Scholar
    • Export Citation
  • 131.

    Wallace MCTator CH: Successful improvement of blood pressure, cardiac output, and spinal cord blood flow after experimental spinal cord injury. Neurosurgery 20:7107151987Wallace MC Tator CH: Successful improvement of blood pressure cardiac output and spinal cord blood flow after experimental spinal cord injury. Neurosurgery 20:710–715 1987

    • Search Google Scholar
    • Export Citation
  • 132.

    Wallace MCTator CHFrazee P: Relationship between posttraumatic ischemia and hemorrhage in the injured rat spinal cord as shown by colloidal carbon angiography. Neurosurgery 18:4334391986Wallace MC Tator CH Frazee P: Relationship between posttraumatic ischemia and hemorrhage in the injured rat spinal cord as shown by colloidal carbon angiography. Neurosurgery 18:433–439 1986

    • Search Google Scholar
    • Export Citation
  • 133.

    Wallace MCTator CHLewis AJ: Chronic regenerative changes in the spinal cord after cord compression injury in rats. Surg Neurol 27:2092191987Wallace MC Tator CH Lewis AJ: Chronic regenerative changes in the spinal cord after cord compression injury in rats. Surg Neurol 27:209–219 1987

    • Search Google Scholar
    • Export Citation
  • 134.

    Weir B: Calcium antagonists, cerebral ischemia and vasospasm. Can J Neurol Sci 11:2392461984Weir B: Calcium antagonists cerebral ischemia and vasospasm. Can J Neurol Sci 11:239–246 1984

    • Search Google Scholar
    • Export Citation
  • 135.

    Westerberg EMonaghan DTCotman CW: Excitatory amino acid receptors and ischemia brain damage in the rat. Neurosci Lett 73:1191241987Westerberg E Monaghan DT Cotman CW: Excitatory amino acid receptors and ischemia brain damage in the rat. Neurosci Lett 73:119–124 1987

    • Search Google Scholar
    • Export Citation
  • 136.

    White BCHoehner PJWilson RFet al: Mitochondrial O use and ATP synthesis: kinetic effects of Ca++ and HPO modulated by glucocorticoids. Ann Emerg Med 9:3964031980White BC Hoehner PJ Wilson RF et al: Mitochondrial O use and ATP synthesis: kinetic effects of Ca++ and HPO modulated by glucocorticoids. Ann Emerg Med 9:396–403 1980

    • Search Google Scholar
    • Export Citation
  • 137.

    Wieloch T: Neurochemical correlates to selective neuronal vulnerability. Prog Brain Res 63:69851985Wieloch T: Neurochemical correlates to selective neuronal vulnerability. Prog Brain Res 63:69–85 1985

    • Search Google Scholar
    • Export Citation
  • 138.

    Wong EHFKemp JAPreistley Tet al: The anticonvulsant MK-801 is potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 83:710471081986Wong EHF Kemp JA Preistley T et al: The anticonvulsant MK-801 is potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 83:7104–7108 1986

    • Search Google Scholar
    • Export Citation
  • 139.

    Wood JHSimeone FAFink EAet al: Hypervolemic hemodilution in experimental focal cerebral ischemia. Elevation of cardiac output, regional cortical blood flow, and ICP after intravascular volume expansion with low molecular weight dextran. J Neurosurg 59:5005091983Wood JH Simeone FA Fink EA et al: Hypervolemic hemodilution in experimental focal cerebral ischemia. Elevation of cardiac output regional cortical blood flow and ICP after intravascular volume expansion with low molecular weight dextran. J Neurosurg 59:500–509 1983

    • Search Google Scholar
    • Export Citation
  • 140.

    Young W: The post-injury response in trauma and ischemia. Secondary injury or protective mechanisms? Cent Nerv Syst Trauma 4:27511987Young W: The post-injury response in trauma and ischemia. Secondary injury or protective mechanisms? Cent Nerv Syst Trauma 4:27–51 1987

    • Search Google Scholar
    • Export Citation
  • 141.

    Young WDe Crescito VTomasula JJ: Effect of sympathectomy on spinal blood flow autoregulation and posttraumatic ischemia. J Neurosurg 56:7067101982Young W De Crescito V Tomasula JJ: Effect of sympathectomy on spinal blood flow autoregulation and posttraumatic ischemia. J Neurosurg 56:706–710 1982

    • Search Google Scholar
    • Export Citation
  • 142.

    Young WFlamm ES: Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury. J Neurosurg 57:6676731982Young W Flamm ES: Effect of high-dose corticosteroid therapy on blood flow evoked potentials and extracellular calcium in experimental spinal injury. J Neurosurg 57:667–673 1982

    • Search Google Scholar
    • Export Citation
  • 143.

    Young WFlamm ESDemopoulos HB: Effect of naxolone on posttraumatic ischemia in experimental spinal contusion. J Neurosurg 55:2092191981Young W Flamm ES Demopoulos HB: Effect of naxolone on posttraumatic ischemia in experimental spinal contusion. J Neurosurg 55:209–219 1981

    • Search Google Scholar
    • Export Citation
  • 144.

    Young WJosovitz KMorales Oet al: The effect of nimodipine on post-ischemic glucose utilization and blood flow in the rat. Anesthesiology 67:54591987Young W Josovitz K Morales O et al: The effect of nimodipine on post-ischemic glucose utilization and blood flow in the rat. Anesthesiology 67:54–59 1987

    • Search Google Scholar
    • Export Citation
  • 145.

    Young WKoreh I: Potassium and calcium changes in injured spinal cords. Brain Res 365:42531986Young W Koreh I: Potassium and calcium changes in injured spinal cords. Brain Res 365:42–53 1986

    • Search Google Scholar
    • Export Citation
  • 146.

    Young WYen VBlight A: Extracellular calcium ionic activity in experimental spinal cord contusion. Brain Res 253:1051131982Young W Yen V Blight A: Extracellular calcium ionic activity in experimental spinal cord contusion. Brain Res 253:105–113 1982

    • Search Google Scholar
    • Export Citation
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