Metastatic intracranial carcinoid with immunohistochemical observation

Case report

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  • 1 Department of Neurosurgery, Toyama Prefectural Central Hospital, Toyama, and Departments of Pathology and Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan
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✓ A case of metastatic carcinoid tumor in the right occipital lobe originating from a primary tumor in the right colon is reported in a 68-year-old man. The tumor had a high bromodeoxyuridine labeling index. Although immunohistochemical studies of the tumor specimen showed positive reactivity for serotonin and somatostatin, blood levels of serotonin and urinary 5-hydroxyindoleacetic acid content were normal. This suggests that coexistence of somatostatin with serotonin in the tumor tissue might lead to inhibition of serotonin release by “autocrine regulation.” The neurological complications of carcinoid tumors, including intracranial metastasis, are discussed briefly.

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Contributor Notes

Address reprint requests to: Tsunenori Ozawa, M.D., Department of Neurosurgery, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951, Japan.
  • 1.

    Berry EM, , Maunder C, & Wilson M: Carcinoid myopathy and treatment with cyproheptadine (Periactin). Gut 15:3438, 1974 Berry EM, Maunder C, Wilson M: Carcinoid myopathy and treatment with cyproheptadine (Periactin). Gut 15:34–38, 1974

    • Search Google Scholar
    • Export Citation
  • 2.

    Bouldin TW, , Killebrew K, & Boone SC, et al. : Metastasis of a rectal carcinoid to the posterior fossa. Neurosurgery 5:496499, 1979 Bouldin TW, Killebrew K, Boone SC, et al: Metastasis of a rectal carcinoid to the posterior fossa. Neurosurgery 5:496–499, 1979

    • Search Google Scholar
    • Export Citation
  • 3.

    Ghatei MA, , Stratton MR, & Allen JM, et al. : Co-secretion of calcitonin gene-related peptide, gastrin-releasing peptide and ACTH by a carcinoid tumor metastasizing to the cerebellum. Postgrad Med J 63:123130, 1987 Ghatei MA, Stratton MR, Allen JM, et al: Co-secretion of calcitonin gene-related peptide, gastrin-releasing peptide and ACTH by a carcinoid tumor metastasizing to the cerebellum. Postgrad Med J 63:123–130, 1987

    • Search Google Scholar
    • Export Citation
  • 4.

    Godwin JD: Carcinoid tumors: an analysis of 2,837 cases. Cancer 36:560569, 1975 Godwin JD: Carcinoid tumors: an analysis of 2,837 cases. Cancer 36:560–569, 1975

    • Search Google Scholar
    • Export Citation
  • 5.

    Gould VE: Neuroendocrinomas and neuroendocrine carcinomas: APUD cell system neoplasms and their aberrant secretory activities. Pathol Annu 12:3362, 1977 Gould VE: Neuroendocrinomas and neuroendocrine carcinomas: APUD cell system neoplasms and their aberrant secretory activities. Pathol Annu 12:33–62, 1977

    • Search Google Scholar
    • Export Citation
  • 6.

    Green D, , Joynt RJ, & Van Allen MW: Neuromyopathy associated with a malignant carcinoid tumor. Arch Intern Med 114:494496, 1964 Green D, Joynt RJ, Van Allen MW: Neuromyopathy associated with a malignant carcinoid tumor. Arch Intern Med 114:494–496, 1964

    • Search Google Scholar
    • Export Citation
  • 7.

    Hajdu SI, , Winawer SJ, & Myers WPL: Carcinoid tumors: a study of 204 cases. Am J Clin Pathol 61:521528, 1974 Hajdu SI, Winawer SJ, Myers WPL: Carcinoid tumors: a study of 204 cases. Am J Clin Pathol 61:521–528, 1974

    • Search Google Scholar
    • Export Citation
  • 8.

    Hoshino T, , Nagashima T, & Cho KG, et al. : S-phase fraction of human brain tumors in situ measured by uptake of bromodeoxyuridine. Int J Cancer 38:369374, 1986 Hoshino T, Nagashima T, Cho KG, et al: S-phase fraction of human brain tumors in situ measured by uptake of bromodeoxyuridine. Int J Cancer 38:369–374, 1986

    • Search Google Scholar
    • Export Citation
  • 9.

    Kamiya H, , Nagai S, & Sakai K, et al. : [A case report of so called “carcinoid tumor of the uterine cervix.”] J Jpn Soc Clin Cytol 25:808815, 1986 (Jpn) Kamiya H, Nagai S, Sakai K, et al: [A case report of so called “carcinoid tumor of the uterine cervix.”] J Jpn Soc Clin Cytol 25:808–815, 1986 (Jpn)

    • Search Google Scholar
    • Export Citation
  • 10.

    Karkos J: Obraz morfologiczny przerzutu rakowiaka jelita biodrowego do mózz̄dz̄ku. Neuropatol Pol 9:231237, 1971 Karkos J: Obraz morfologiczny przerzutu rakowiaka jelita biodrowego do móz̄dz̄ku. Neuropatol Pol 9:231–237, 1971

    • Search Google Scholar
    • Export Citation
  • 11.

    Kovachev D, & Ruseva V: Kartsinoid na stomakhas/metastazi v tvurdata mozuchna obvivka. Vutr Boles 15:98103, 1976 Kovachev D, Ruseva V: Kartsinoid na stomakhas/metastazi v tvurdata mozuchna obvivka. Vutr Boles 15:98–103, 1976

    • Search Google Scholar
    • Export Citation
  • 12.

    Kvols LK: Metastatic carcinoid tumors and the carcinoid syndrome: a selective review of chemotherapy and hormonal therapy. Am J Med 81:4955, 1986 Kvols LK: Metastatic carcinoid tumors and the carcinoid syndrome: a selective review of chemotherapy and hormonal therapy. Am J Med 81:49–55, 1986

    • Search Google Scholar
    • Export Citation
  • 13.

    Lehmann J: Mental disturbances followed by stupor in a patient with carcinoidosis. Acta Psychiatr Scand 42:153161, 1966 Lehmann J: Mental disturbances followed by stupor in a patient with carcinoidosis. Acta Psychiatr Scand 42:153–161, 1966

    • Search Google Scholar
    • Export Citation
  • 14.

    Lubarsch O: Ueber den primaren Krebs des Ileum nebst Bemerkingen über das gleichzeitige Vorkommen von Krebs and Tuberkulose. Virchows Arch Pathol Anat III:280317, 1888 Lubarsch O: Ueber den primaren Krebs des Ileum nebst Bemerkingen über das gleichzeitige Vorkommen von Krebs and Tuberkulose. Virchows Arch Pathol Anat III:280–317, 1888

    • Search Google Scholar
    • Export Citation
  • 15.

    Moertel CG: Treatment of the carcinoid tumor and the malignant carcinoid syndrome. J Clin Oncol 1:727740, 1983 Moertel CG: Treatment of the carcinoid tumor and the malignant carcinoid syndrome. J Clin Oncol 1:727–740, 1983

    • Search Google Scholar
    • Export Citation
  • 16.

    Moertel CG, , Weiland LH, & Nagorney DM, et al. : Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med 317:16991701, 1987 Moertel CG, Weiland LH, Nagorney DM, et al: Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med 317:1699–1701, 1987

    • Search Google Scholar
    • Export Citation
  • 17.

    Moran RE, & Straus MJ: Labeling indices of human lung cancer. Correlation with histologic type and survival. Anal Quant Cytol 5:250254, 1983 Moran RE, Straus MJ: Labeling indices of human lung cancer. Correlation with histologic type and survival. Anal Quant Cytol 5:250–254, 1983

    • Search Google Scholar
    • Export Citation
  • 18.

    Murata Y, , Tanaka I, & Aratake K, et al. : [Autopsy case of malignant gastric carcinoid with atypical spinal lesion.] Nippon Rinsho 32:403410, 1974 (Jpn) Murata Y, Tanaka I, Aratake K, et al: [Autopsy case of malignant gastric carcinoid with atypical spinal lesion.] Nippon Rinsho 32:403–410, 1974 (Jpn)

    • Search Google Scholar
    • Export Citation
  • 19.

    Murayama K, , Shimura T, & Isayama K, et al. : A case of skull and dural metastases of carcinoid tumor of the urinary bladder. Neurol Surg 11:643649, 1983 Murayama K, Shimura T, Isayama K, et al: A case of skull and dural metastases of carcinoid tumor of the urinary bladder. Neurol Surg 11:643–649, 1983

    • Search Google Scholar
    • Export Citation
  • 20.

    Nagashima T, , DeArmond SJ, & Murovic J, et al. : Immunocytochemical demonstration of S-phase cells by antibromodeoxyuridine monoclonal antibody in human brain tumor tissue. Acta Neuropathol 67:155159, 1985 Nagashima T, DeArmond SJ, Murovic J, et al: Immunocytochemical demonstration of S-phase cells by antibromodeoxyuridine monoclonal antibody in human brain tumor tissue. Acta Neuropathol 67:155–159, 1985

    • Search Google Scholar
    • Export Citation
  • 21.

    Nagashima T, , Hoshino T, & Cho KG, et al. : Comparison of bromodeoxyuridine labeling indices obtained from tissue sections and flow cytometry of brain tumors. J Neurosurg 68:388392, 1988 Nagashima T, Hoshino T, Cho KG, et al: Comparison of bromodeoxyuridine labeling indices obtained from tissue sections and flow cytometry of brain tumors. J Neurosurg 68:388–392, 1988

    • Search Google Scholar
    • Export Citation
  • 22.

    Oberndorfer S: Karzenoide Tumoren des Dünndarms. Frankfurt Z Pathol 1:426429, 1907 Oberndorfer S: Karzenoide Tumoren des Dünndarms. Frankfurt Z Pathol 1:426–429, 1907

    • Search Google Scholar
    • Export Citation
  • 23.

    Pearson CM, & Fitzgerald PJ: Carcinoid tumors: a reemphasis of their malignant nature. Review of 140 cases. Cancer 2:10051026, 1949 Pearson CM, Fitzgerald PJ: Carcinoid tumors: a reemphasis of their malignant nature. Review of 140 cases. Cancer 2:1005–1026, 1949

    • Search Google Scholar
    • Export Citation
  • 24.

    Petchell RA, & Posner JB: Neurologic complications of carcinoid. Neurology 36:745749, 1986 Petchell RA, Posner JB: Neurologic complications of carcinoid. Neurology 36:745–749, 1986

    • Search Google Scholar
    • Export Citation
  • 25.

    Pollard A, , Grainger RG, & Fleming O, et al. : An unusual case of metastasising bronchial “adenoma” associated with the carcinoid syndrome. Lancet 2:10841086, 1962 Pollard A, Grainger RG, Fleming O, et al: An unusual case of metastasising bronchial “adenoma” associated with the carcinoid syndrome. Lancet 2:1084–1086, 1962

    • Search Google Scholar
    • Export Citation
  • 26.

    Reichlin S: Somatostatin. N Engl J Med 309:14951501, 1983 Reichlin S: Somatostatin. N Engl J Med 309:1495–1501, 1983

  • 27.

    Rossi ML, , Bevan JS, & Fleming KA, et al. : Pituitary metastasis from malignant bronchial carcinoid. Tumori 74:101105, 1988 Rossi ML, Bevan JS, Fleming KA, et al: Pituitary metastasis from malignant bronchial carcinoid. Tumori 74:101–105, 1988

    • Search Google Scholar
    • Export Citation
  • 28.

    Saleh J, & Afshar F: Metastatic carcinoid tumor of the CNS from two different primary sites. Br J Neurosurg 1:281284, 1987 Saleh J, Afshar F: Metastatic carcinoid tumor of the CNS from two different primary sites. Br J Neurosurg 1:281–284, 1987

    • Search Google Scholar
    • Export Citation
  • 29.

    Schiffman FJ, & Barnard NJ: Carcinoid tumor of the gastrointestinal tract with metastases to the brain. Arch Intern Med 142:17171719, 1982 Schiffman FJ, Barnard NJ: Carcinoid tumor of the gastrointestinal tract with metastases to the brain. Arch Intern Med 142:1717–1719, 1982

    • Search Google Scholar
    • Export Citation
  • 30.

    Schmechel C, , Marangos PJ, & Brightman M: Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature 276:34836, 1978 Schmechel C, Marangos PJ, Brightman M: Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature 276:34–836, 1978

    • Search Google Scholar
    • Export Citation
  • 31.

    Smith TW, , Wang S, & Schoene WC: Malignant carcinoid tumor metastatic to a meningioma. Cancer 47:18721877, 1981 Smith TW, Wang S, Schoene WC: Malignant carcinoid tumor metastatic to a meningioma. Cancer 47:1872–1877, 1981

    • Search Google Scholar
    • Export Citation
  • 32.

    Swash M, , Fox KP, & Davidson AR: Carcinoid myopathy. Arch Neurol 32:572574, 1975 Swash M, Fox KP, Davidson AR: Carcinoid myopathy. Arch Neurol 32:572–574, 1975

    • Search Google Scholar
    • Export Citation
  • 33.

    Thulin L, , Samnegard H, & Tyden G, et al. : Efficacy of somatostatin in a patient with carcinoid syndrome. Lancet 2:43, 1978 (Letter) Thulin L, Samnegard H, Tyden G, et al: Efficacy of somatostatin in a patient with carcinoid syndrome. Lancet 2:43, 1978 (Letter)

    • Search Google Scholar
    • Export Citation
  • 34.

    Wagner PK, & Brunner GH: Gastric carcinoid with brain metastases. Med Klin 74:14391443, 1979 Wagner PK, Brunner GH: Gastric carcinoid with brain metastases. Med Klin 74:1439–1443, 1979

    • Search Google Scholar
    • Export Citation
  • 35.

    Wareing TH, & Sawyers JL: Carcinoids and the carcinoid syndrome. Am J Surg 145:769772, 1983 Wareing TH, Sawyers JL: Carcinoids and the carcinoid syndrome. Am J Surg 145:769–772, 1983

    • Search Google Scholar
    • Export Citation
  • 36.

    Warner TFCS, & Seo IS: Bronchial carcinoid appearing as a breast mass. Arch Pathol Lab Med 104:531534, 1980 Warner TFCS, Seo IS: Bronchial carcinoid appearing as a breast mass. Arch Pathol Lab Med 104:531–534, 1980

    • Search Google Scholar
    • Export Citation
  • 37.

    Warren WH, , Memoli VA, & Gould VE: Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms. I. Carcinoids. Ultrastruct Pathol 6:1527, 1984 Warren WH, Memoli VA, Gould VE: Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms. I. Carcinoids. Ultrastruct Pathol 6:15–27, 1984

    • Search Google Scholar
    • Export Citation

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