Possible protective effect of endogenous opioids in traumatic brain injury

Ronald L. Hayes Ph.D.1, Bruce G. Lyeth Ph.D.1, Larry W. Jenkins Ph.D.1, Richard Zimmerman M.D.1, Tracy K. McIntosh Ph.D.1, Guy L. Clifton M.D.1, and Harold F. Young M.D.1
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  • 1 Division of Neurosurgery, Richard Roland Reynolds Neurosurgical Research Laboratories, Department of Surgery, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia
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252–261
Volume/Issue:
Volume 72: Issue 2
DOI link:
https://doi.org/10.3171/jns.1990.72.2.0252
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✓ Naloxone (0.1, 1.0, or 20.0 mg/kg), morphine (1.0 or 10.0 mg/kg), or saline was administered systemically intraperitoneally to rats 15 minutes prior to moderate fluid-percussion brain injury. The effects of the drugs were measured on systemic physiological, neurological, and body-weight responses to injury. The animals were trained prior to injury and were assessed for 10 days after injury on body-weight responses and neurological endpoints. Low doses of naloxone (0.1 or 1.0 mg/kg) significantly exacerbated neurological deficits associated with injury. Morphine (10.0 mg/kg) significantly reduced neurological deficits associated with injury. The drugs had no effect on neurological measures or body weight in sham-injured animals. Drug treatments did not significantly alter systemic physiological responses to injury. Data from these experiments suggest the involvement of endogenous opioids in at least some components of neurological deficits following traumatic brain injury and suggest the possibility that at least some classes of endogenous opioids may protect against long-term neurological deficits produced by fluid-percussion injury to the rat.

Volume 72: Issue 2 (Feb 1990)

in Journal of Neurosurgery
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