Calcifying pseudoneoplasms of the neural axis

Franco Bertoni Section of Surgical Pathology, and Departments of Diagnostic Radiology and Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

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K. Krishnan Unni Section of Surgical Pathology, and Departments of Diagnostic Radiology and Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

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David C. Dahlin Section of Surgical Pathology, and Departments of Diagnostic Radiology and Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

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John W. Beabout Section of Surgical Pathology, and Departments of Diagnostic Radiology and Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

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Burton M. Onofrio Section of Surgical Pathology, and Departments of Diagnostic Radiology and Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

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✓ An unusual fibrocalcifying lesion of the neural axis was identified in 14 cases. The radiographic appearance was that of a mass, which in some instances was calcified. The surrounding structures were compressed and the adjacent bone was involved. Histologically, the process was basically a granulomatous one. The granulomas were either nodular or confluent, producing a large mass with peripheral lobular configuration. Epithelioid cells and giant cells bordered the granulomas. Most of the granulomas were composed of fibrochondrocalcifying material. The lesion was particularly dangerous when located in a strategic site, such as the foramen magnum or the base of the skull. Two of the 14 patients with this pseudotumor died, and the other 12 have done well. Complete ablation, marginal or even intralesional, assures control of the lesion. The lesion is probably reactive rather than neoplastic.

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  • 1.

    Dahlin DC, & Unni KK: Bone Tumors: General Aspects and Data on 8,542 Cases, ed 4. Springfield, Ill: Charles C Thomas, 1986 Dahlin DC, Unni KK: Bone Tumors: General Aspects and Data on 8,542 Cases, ed 4. Springfield, Ill: Charles C Thomas, 1986

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  • 2.

    Jun C, & Burdick B: An unusual fibro-osseous lesion of the brain. Case report. J Neurosurg 60:13081311, 1984 Jun C, Burdick B: An unusual fibro-osseous lesion of the brain. Case report. J Neurosurg 60:1308–1311, 1984

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  • 3.

    Rhodes RH, & Davis RL: An unusual fibro-osseous component in intracranial lesions. Hum Pathol 9:309319, 1978 Rhodes RH, Davis RL: An unusual fibro-osseous component in intracranial lesions. Hum Pathol 9:309–319, 1978

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  • 4.

    Zülch KJ: Brain Tumors: Their Biology and Pathology, ed 3. Berlin: Springer-Verlag, 1986, pp 736737 Zülch KJ: Brain Tumors: Their Biology and Pathology, ed 3. Berlin: Springer-Verlag, 1986, pp 736–737

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