Primary cerebral angiosarcoma

Case report

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✓ A 65-year-old man with a history of exposure to industrial solvents developed a primary cerebral angiosarcoma in the left posterior parieto-occipital lobe. The tumor had features typical of angiosarcoma on light and electron microscopy, immunohistochemical evidence of factor VIII-related antigen produced in tumor cells, and a high labeling index with bromodeoxyuridine. The relationship of angiosarcoma to toxins and viruses is discussed.

Article Information

Dr. Charman was an American Cancer Society Clinical Oncology Fellow during this study.

Address reprint requests to: Stephen J. DeArmond, M.D., Ph.D., Department of Pathology, School of Medicine, University of California, San Francisco, California 94143-0114.

© AANS, except where prohibited by US copyright law.

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Figures

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    Axial T2-weighted magnetic resonance image (TR 2000 msec, TE 80 msec) showing a well-encapsulated mass with a low signal intensity and a central focus of higher signal intensity representing hemorrhage. The area of higher signal intensity surrounding the central mass corresponds to white matter edema.

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    Photomicrograph of a paraffin-embedded section of the surgical specimen showing malignant endothelial cells lining the vascular channels. H & E, × 160.

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    Electron micrographs of preparations of the mass. Left: Red blood cells are seen within the vascular channels lined by endothelial cells containing microvilli (V), intracytoplasmic channels (C), and abluminal basal lamina material (B). × 2000. Right: Higher-power view showing a malignant endothelial cell containing intracytoplasmic channels (arrows), × 6000.

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