Plasminogen activator activity and molecular weight patterns in human brain tumors

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  • 1 Department of Neurosurgery and Departments of Physiology and Biophysics, University of Cincinnati College of Medicine and Veterans Administration Hospital, Cincinnati, Ohio
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✓ Fresh human brain-tumor samples were assayed for their plasminogen activator (PA) content. Specific molecular weight patterns were identified for each of five common brain tumors and for normal brain, suggesting a cell-specific origin of the various PA forms. Malignant tumors contained higher PA activity and a larger number of molecular weight patterns than benign tumors, with the exception of acoustic neurinomas. Irradiated tumors contained lower PA activity than nonirradiated tumors. Finally, a slight but definite correlation between brain edema and PA activity was detected. The future role of brain-tumor PA's for diagnostic and therapeutic purposes is discussed.

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Contributor Notes

Address reprint requests to: Raymond Sawaya, M.D., Department of Neurosurgery, University of Cincinnati Medical Center, 231 Bethesda Avenue (M.L. 515), Cincinnati, Ohio 45267.
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