Hyperprolactinemia, intrasellar pituitary tissue pressure, and the pituitary stalk compression syndrome

Peter D. Lees F.R.C.S.1 and John D. Pickard M.Chir., F.R.C.S.1
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  • 1 Wessex Neurological Centre, Southampton General Hospital Southampton, England
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✓ The intrasellar pressure has been studied in a consecutive series of 24 patients undergoing transsphenoidal surgery for pituitary adenoma. The mean intrasellar pressure for the group was 23 ± 2.5 mm Hg (± standard error of the mean), with a mean pulse pressure of 3.5 ± 1 mm Hg. The waveform partly resembled the arterial configuration. The results are correlated with the radiological and endocrinological features of the tumors. A hypothesis is proposed to explain the mechanism of hyperprolactinemia associated with the pituitary stalk compression syndrome.

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