Beagle puppy model of perinatal cerebral insults

Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia

View More View Less
  • 1 Departments of Pediatrics, Neurology, Neurosurgery, Anatomy, and Anesthesiology, Yale University School of Medicine, New Haven, Connecticut
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $515.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $612.00
Print or Print + Online

✓ Asphyxia, with its attendant hypoxemia, is by far the most common cause of neonatal cerebral infarction, and frequently results in lesions of the parieto-occipital white matter in addition to other neuropathological changes. This study examines the effects of hypoxemia on regional cerebral blood flow (CBF) in the newborn beagle pup. The animals were anesthetized, underwent a tracheotomy, and were paralyzed. Pups were randomly divided into two groups: one group was subjected to hypoxemia produced by altering the oxygen concentration in the inspired air, and the other received no insult. In the hypoxemic pups, the pO2 was 13.1 ± 2.1 mm Hg (mean ± standard deviation). Autoradiographic determinations of CBF were performed by the carbon-14-iodoantipyrine technique 15 minutes after randomization. Significant increases in CBF were found throughout the brains of the hypoxemic pups. The CBF was increased to cortical and central gray regions and to frontal and temporal white matter but was unchanged in the parietal white matter, one of the classic sites of radiological and neuropathological injury in neonates with perinatal asphyxia. An unexpected finding was the increased incidence of germinal matrix and/or intraventricular hemorrhages in the hypoxemic pups.

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $515.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $612.00
  • 1.

    Cavazzuti M, & Duffy TE: Regulation of local cerebral blood flow in normal and hypoxic newborn dogs. Ann Neurol 11:247257, 1982 Cavazzuti M, Duffy TE: Regulation of local cerebral blood flow in normal and hypoxic newborn dogs. Ann Neurol 11:247–257, 1982

    • Search Google Scholar
    • Export Citation
  • 2.

    Donat JF, , Okazaki H, & Kleinberg F, et al: Intraventricular hemorrhages in full-term and premature infants. Mayo Clin Proc 53:437441, 1978 Donat JF, Okazaki H, Kleinberg F, et al: Intraventricular hemorrhages in full-term and premature infants. Mayo Clin Proc 53:437–441, 1978

    • Search Google Scholar
    • Export Citation
  • 3.

    Duffy TE, , Cavazzuti M, & Cruz NF, et al: Local cerebral glucose metabolism in newborn dogs: effects of hypoxia and halothane anesthesia. Ann Neurol 11:233246, 1982 Duffy TE, Cavazzuti M, Cruz NF, et al: Local cerebral glucose metabolism in newborn dogs: effects of hypoxia and halothane anesthesia. Ann Neurol 11:233–246, 1982

    • Search Google Scholar
    • Export Citation
  • 4.

    Feldman GB, & Freiman JA: Prophylactic cesarean section at term? N Engl J Med 312:12641267, 1985 Feldman GB, Freiman JA: Prophylactic cesarean section at term? N Engl J Med 312:1264–1267, 1985

    • Search Google Scholar
    • Export Citation
  • 5.

    Fenichel GM: Hypoxic-ischemic encephalopathy in the newborn. Arch Neurol 40:261266, 1983 Fenichel GM: Hypoxic-ischemic encephalopathy in the newborn. Arch Neurol 40:261–266, 1983

    • Search Google Scholar
    • Export Citation
  • 6.

    Goddard J, , Lewis RM, & Alcala H, et al: Intraventricular hemorrhage — an animal model. Biol Neonate 37:3952, 1980 Goddard J, Lewis RM, Alcala H, et al: Intraventricular hemorrhage — an animal model. Biol Neonate 37:39–52, 1980

    • Search Google Scholar
    • Export Citation
  • 7.

    Goddard-Finegold J: Periventricular, intraventricular hemorrhages in the premature newborn. Update on pathologic features, pathogenesis and possible means of prevention. Arch Neurol 41:766771, 1984 Goddard-Finegold J: Periventricular, intraventricular hemorrhages in the premature newborn. Update on pathologic features, pathogenesis and possible means of prevention. Arch Neurol 41:766–771, 1984

    • Search Google Scholar
    • Export Citation
  • 8.

    Kennedy C, , Grave GD, & Jehle JW: Effect of hyperoxia on the cerebral circulation of the newborn puppy. Pediatr Res 5:659667, 1971 Kennedy C, Grave GD, Jehle JW: Effect of hyperoxia on the cerebral circulation of the newborn puppy. Pediatr Res 5:659–667, 1971

    • Search Google Scholar
    • Export Citation
  • 9.

    Koehler RC, , Traystman RJ, & Zeger S, et al: Comparison of cerebrovascular response to hypoxic and carbon monoxide hypoxia in newborn and adult sheep. J Cereb Blood Flow Metab 4:115122, 1984 Koehler RC, Traystman RJ, Zeger S, et al: Comparison of cerebrovascular response to hypoxic and carbon monoxide hypoxia in newborn and adult sheep. J Cereb Blood Flow Metab 4:115–122,1984

    • Search Google Scholar
    • Export Citation
  • 10.

    Laptook A, , Stonestreet BW, & Oh W: The effects of different rates of plasmanate infusions upon brain blood flow after asphyxia and hypotension in newborn piglets. J Pediatr 100:791796, 1982 Laptook A, Stonestreet BW, Oh W: The effects of different rates of plasmanate infusions upon brain blood flow after asphyxia and hypotension in newborn piglets. J Pediatr 100:791–796, 1982

    • Search Google Scholar
    • Export Citation
  • 11.

    Larroche JC: Post-haemorrhagic hydrocephalus in infancy. Anatomical study. Biol Neonate 20:287299, 1972 Larroche JC: Post-haemorrhagic hydrocephalus in infancy. Anatomical study. Biol Neonate 20:287–299, 1972

    • Search Google Scholar
    • Export Citation
  • 12.

    Lou HC: Perinatal hypoxic-ischemic brain damage and intraventricular hemorrhage. A pathogenetic model. Arch Neurol 37:585587, 1980 Lou HC: Perinatal hypoxic-ischemic brain damage and intraventricular hemorrhage. A pathogenetic model. Arch Neurol 37:585–587, 1980

    • Search Google Scholar
    • Export Citation
  • 13.

    Lou HC, , Lassen NA, & Tweed WA, et al: Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia. Acta Paediatr Scand 68:5763, 1979 Lou HC, Lassen NA, Tweed WA, et al: Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia. Acta Paediatr Scand 68:57–63, 1979

    • Search Google Scholar
    • Export Citation
  • 14.

    McCormick MC: The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 312:8290, 1985 McCormick MC: The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 312:82–90, 1985

    • Search Google Scholar
    • Export Citation
  • 15.

    Ment LR, , Duncan CC, & Ehrenkranz RA, et al: Intraventricular hemorrhage in the preterm neonate: timing and cerebral blood flow changes. J Pediatr 104:419425, 1984 Ment LR, Duncan CC, Ehrenkranz RA, et al: Intraventricular hemorrhage in the preterm neonate: timing and cerebral blood flow changes. J Pediatr 104:419–425, 1984

    • Search Google Scholar
    • Export Citation
  • 16.

    Ment LR, , Stewart WB, & Duncan CC: Beagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins. J Neurosurg 62:563569, 1985 Ment LR, Stewart WB, Duncan CC: Beagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins. J Neurosurg 62:563–569, 1985

    • Search Google Scholar
    • Export Citation
  • 17.

    Ment LR, , Stewart WB, & Duncan CC: Beagle puppy model of intraventricular hemorrhage: ethamsylate studies. Prostaglandins 27:245256, 1984 Ment LR, Stewart WB, Duncan CC: Beagle puppy model of intraventricular hemorrhage: ethamsylate studies. Prostaglandins 27:245–256, 1984

    • Search Google Scholar
    • Export Citation
  • 18.

    Pasternak JF, , Groothuis DR, & Fischer JM, et al: Regional cerebral blood flow in the newborn beagle pup: the germinal matrix is a “low-flow” structure. Pediatr Res 16:499503, 1982 Pasternak JF, Groothuis DR, Fischer JM, et al: Regional cerebral blood flow in the newborn beagle pup: the germinal matrix is a “low-flow” structure. Pediatr Res 16:499–503, 1982

    • Search Google Scholar
    • Export Citation
  • 19.

    Perlman JM, & Volpe JJ: Cerebral blood flow velocity in relation to intraventricular hemorrhage in the premature newborn infant. J Pediatr 100:956959, 1982 Perlman JM, Volpe JJ: Cerebral blood flow velocity in relation to intraventricular hemorrhage in the premature newborn infant. J Pediatr 100:956–959, 1982

    • Search Google Scholar
    • Export Citation
  • 20.

    Sankaran K, , Peters K, & Finer N: Estimated cerebral blood flow in term infants with hypoxic-ischemic encephalopathy. Pediatr Res 15:14151418, 1981 Sankaran K, Peters K, Finer N: Estimated cerebral blood flow in term infants with hypoxic-ischemic encephalopathy. Pediatr Res 15:1415–1418, 1981

    • Search Google Scholar
    • Export Citation
  • 21.

    Vannucci RC, & Duffy TE: Cerebral metabolism in newborn dogs during reversible asphyxia. Ann Neurol 1:528534, 1977 Vannucci RC, Duffy TE: Cerebral metabolism in newborn dogs during reversible asphyxia. Ann Neurol 1:528–534, 1977

    • Search Google Scholar
    • Export Citation
  • 22.

    Volpe JJ, & Pasternak JF: Parasagittal cerebral injury in neonatal hypoxic-ischemic encephalopathy: clinical and neuroradiologic features. J Pediatr 91:472476, 1977 Volpe JJ, Pasternak JF: Parasagittal cerebral injury in neonatal hypoxic-ischemic encephalopathy: clinical and neuroradiologic features. J Pediatr 91:472–476, 1977

    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 242 50 5
Full Text Views 211 5 0
PDF Downloads 98 3 0
EPUB Downloads 0 0 0