Effect of hyperglycemia on brain pH levels in areas of focal incomplete cerebral ischemia in monkeys

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✓ The adverse effect of a minimal cerebral blood flow (CBF) in models of global ischemia has been noted by many investigators. One factor believed important in this situation is the level of blood glucose, since a continued supply of this metabolite results in increased tissue lactate, decreased brain pH, and increased cell damage. The authors have extended these observations to a model of focal incomplete ischemia. Brain pH was measured in fasted squirrel monkeys in regions of focal incomplete ischemia after transorbital occlusion of the middle cerebral artery (MCA). In both control and hyperglycemic animals, CBF was reduced to less than 30% of baseline. At 3 hours after MCA occlusion, brain pH in the control group was 6.66 ± 0.68 as compared to 6.27 ± 0.26 in the glucose-treated group. This difference was statistically significant by Student's unpaired t-test (p < 0.05). Thus, hyperglycemia results in decreased tissue pH in regions of focal incomplete cerebral ischemia in monkeys.

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Address reprint requests to: W. Richard Marsh, M.D., Department of Neurosurgery, Mayo Clinic, Mayo Medical School, Rochester, Minnesota 55905.

© AANS, except where prohibited by US copyright law.

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    Graph summarizing the mean values in the six monkeys infused with saline (solid line) and the six infused with glucose (dashed line). Standard errors were too small to depict graphically at some measurement points. † = time of death; MCA = middle cerebral artery; D5W = 5% dextrose in water.

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