Serum and urine zinc response in head-injured patients

Craig J. McClain Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Diana L. Twyman Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Linda G. Ott Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Robert P. Rapp Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Phillip A. Tibbs Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Jane A. Norton Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Edward J. Kasarskis Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Robert J. Dempsey Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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Byron Young Divisions of Gastroenterology and Neurosurgery, Veterans Administration Hospital, Lexington, and College of Medicine and College of Pharmacy, University of Kentucky, Lexington, Kentucky, and Department of Surgery, Henry Ford Hospital, Detroit, Michigan

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✓ A prospective longitudinal evaluation of serum zinc concentrations was performed in 26 head-trauma patients, and 24-hour urine zinc excretion was determined in 15 of these subjects. Patients had markedly depressed admission serum zinc concentrations (mean ± standard error of the mean: 40.2 ± 3.2 µg/dl; normal values: 70 to 120 µg/dl), which gradually increased during the 16-day study period. All subjects demonstrated increased urinary zinc losses throughout the study period. Urinary zinc excretion was greater in patients with more severe head injuries. Indeed, patients with more severe head trauma had mean peak urinary zinc losses of greater than 7000 µg/day (normal less than 500 (µg/day). The implications of this altered zinc metabolism for protein metabolism, wound healing, and immune function, and the specific role of zinc in brain function and recovery from injury are discussed.

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    Yunice AA, , King RW Jr, & Kraikitpanitch S, et al: Urinary zinc excretion following infusions of zinc sulfate, cysteine, histidine, or glycine. Am J Physiol 235:F40F45, 1978 Yunice AA, King RW Jr, Kraikitpanitch S, et al: Urinary zinc excretion following infusions of zinc sulfate, cysteine, histidine, or glycine. Am J Physiol 235:F40–F45, 1978

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