Regional cerebral blood flow and metabolism in reversible ischemia due to vasospasm

Determination by positron emission tomography

William J. Powers M.D.1, Robert L. Grubb Jr. M.D.1, Roy P. Baker M.D.1, Mark A. Mintun M.D.1, and Marcus E. Raichle M.D.1
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  • 1 Department of Neurology and Neurological Surgery, and Division of Radiation Sciences, The Edward Mallinckrodt Institute of Radiology, and The McDonnell Center for Studies of Higher Brain Function, Washington University School of Medicine, St. Louis, Missouri
Page Range:
539–546
Volume/Issue:
Volume 62: Issue 4
DOI link:
https://doi.org/10.3171/jns.1985.62.4.0539
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✓ Regional cerebral blood flow (rCBF) and regional cerebral metabolic rate of oxygen (rCMRO2) were measured by positron emission tomography (PET) in four patients with subarachnoid hemorrhage and hemiparesis due to cerebral vasospasm. With resolution of the vasospasm, two patients recovered and two remained hemiparetic. Contralateral to the hemiparesis, rCBF was slightly higher in the two patients who eventually recovered (15.0 and 16.2 ml/100 gm/min) than in the two who remained hemiparetic (12.0 and 11.7 ml/100 gm/min). The rCMRO2 measurements showed similar differences, with values of 1.34 and 2.60 ml/100 gm/min in the patients who recovered, and 0.72 and 1.66 ml/100 gm/min in those who did not. These preliminary findings indicate that with PET studies it may be possible to prospectively differentiate patients with neurological deficits due to reversible ischemia from patients with irreversible infarction.

Volume 62: Issue 4 (Apr 1985)

in Journal of Neurosurgery
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