Calcium pyrophosphate dihydrate deposits in the cervical ligamenta flava causing myeloradiculopathy

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  • 1 Department of Neurosurgery, Second Department of Pathology, Laboratory of Electron Microscopy, Department of Neurology, Saitama Medical School, Saitama, and Department of Neurosurgery, Isesaki City Hospital, Gunma-ken, Japan
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✓ Three cases of cervical myeloradiculopathy associated with multiple calcified nodules containing identified calcium pyrophosphate dihydrate (CPPD) crystals in the ligamenta flava are described, with a comprehensive review of the 12 cases of this entity reported to date. The disease is characterized by: 1) oval or triangular areas of radiodensity in the posterior aspect of the cervical canal as seen in the lateral x-ray films and laminograms; 2) hemispherical areas of high density located almost symmetrically in the paramedial portion of the posterior spinal canal on computerized tomography scans; and 3) CPPD crystals in the nodules. It occurs independently or in association with cervical spondylosis or ossification of the posterior longitudinal ligament.

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