Multiple meningiomas: a long-term review

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✓ Ten cases of multiple meningiomas seen over a 34-year period have been reviewed. The total case load from which these cases were selected was 566. The incidence of multiple meningiomas found prior to the introduction of computerized tomography (CT) in this series was 1.1%. The incidence since the introduction of CT was 8%. In eight cases all the tumors were found at the initial presentation and surgery; in the other two cases new tumors were discovered 1 and 4 years later. In only one case was von Recklinghausen's disease known to be present, and this patient developed new tumors. Six cases have been followed for 5 or more years, two for 16 years. Tumor recurrence has not been seen. All the patients were females. There was a higher proportion than usual of the whorling psammomatous type of tumor; papillary, angioblastic or malignant forms were not noted. The possibility of multiple meningiomas being a forme fruste of von Recklinghausen's disease is considered.

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Address reprint requests to: H. Alan Crockard, F.R.C.S., The National Hospital for Nervous Diseases, Queen Square, London WC1N 3BG, England.

© AANS, except where prohibited by US copyright law.

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References
  • 1.

    Anfimow JBlumenau L: Ein Fall Multipler Geschwülste in der Schädelhöhle. Neurol Zentralbl 8:5851889Anfimow J Blumenau L: Ein Fall Multipler Geschwülste in der Schädelhöhle. Neurol Zentralbl 8:585 1889

    • Search Google Scholar
    • Export Citation
  • 2.

    Bonnal JBorn JDTremoulet M: Méningiomes multiples intracraniens. Neurochirurgie 25:78831979Bonnal J Born JD Tremoulet M: Méningiomes multiples intracraniens. Neurochirurgie 25:78–83 1979

    • Search Google Scholar
    • Export Citation
  • 3.

    Cushing HEisenhardt L: Meningiomas: Their Classification Regional Behavior Life History and Surgical End Results. Springfield, Ill: Charles C Thomas1938785 ppCushing H Eisenhardt L: Meningiomas: Their Classification Regional Behavior Life History and Surgical End Results. Springfield Ill: Charles C Thomas 1938 785 pp

    • Search Google Scholar
    • Export Citation
  • 4.

    Donnell MSMeyer GADonegan WL: Estrogen-receptor protein in intracranial meningiomas. J Neurosurg 50:4995021979Donnell MS Meyer GA Donegan WL: Estrogen-receptor protein in intracranial meningiomas. J Neurosurg 50:499–502 1979

    • Search Google Scholar
    • Export Citation
  • 5.

    Ekong CEUPaine KWERozdilsky B: Multiple meningiomas. Surg Neurol 9:1811841978Ekong CEU Paine KWE Rozdilsky B: Multiple meningiomas. Surg Neurol 9:181–184 1978

    • Search Google Scholar
    • Export Citation
  • 6.

    Elsberg CA: Parasagittal meningeal fibroblastomas. Bull Neurol Inst NY 1:3894181931Elsberg CA: Parasagittal meningeal fibroblastomas. Bull Neurol Inst NY 1:389–418 1931

    • Search Google Scholar
    • Export Citation
  • 7.

    Fabricant RNTodaro GJEldridge R: Increased levels of a nerve-growth-factor cross-reacting protein in “central” neurofibromatosis. Lancet 1:471979Fabricant RN Todaro GJ Eldridge R: Increased levels of a nerve-growth-factor cross-reacting protein in “central” neurofibromatosis. Lancet 1:4–7 1979

    • Search Google Scholar
    • Export Citation
  • 8.

    Frazier CHAlpers BJ: Meningeal fibroblastomas of the cerebrum. A clinicopathologic analysis of seventy-five cases. Arch Neurol Psychiatry 29:9359891933Frazier CH Alpers BJ: Meningeal fibroblastomas of the cerebrum. A clinicopathologic analysis of seventy-five cases. Arch Neurol Psychiatry 29:935–989 1933

    • Search Google Scholar
    • Export Citation
  • 9.

    Gaist GPiazza G: Meningiomas in two members of the same family (with no evidence of neurofibromatosis). J Neurosurg 16:1101131959Gaist G Piazza G: Meningiomas in two members of the same family (with no evidence of neurofibromatosis). J Neurosurg 16:110–113 1959

    • Search Google Scholar
    • Export Citation
  • 10.

    Gardner WJFrazier CH: Bilateral acoustic neurofibromas. A clinical study and field survey of a family of five generations with bilateral deafness in thirty-eight members. Arch Neurol Psychiatry 23:2663021930Gardner WJ Frazier CH: Bilateral acoustic neurofibromas. A clinical study and field survey of a family of five generations with bilateral deafness in thirty-eight members. Arch Neurol Psychiatry 23:266–302 1930

    • Search Google Scholar
    • Export Citation
  • 11.

    Girard PFTrillet MConfavreux Cet al: Méningiomatose multiple et familiale. Un syndrome voisin de la neurofibromatose de Recklinghausen. Rev Neurol 133:3593621977Girard PF Trillet M Confavreux C et al: Méningiomatose multiple et familiale. Un syndrome voisin de la neurofibromatose de Recklinghausen. Rev Neurol 133:359–362 1977

    • Search Google Scholar
    • Export Citation
  • 12.

    Heuer GJDandy WE: A report of seventy cases of brain tumor. Bull Johns Hopkins Hosp 27:2242371916Heuer GJ Dandy WE: A report of seventy cases of brain tumor. Bull Johns Hopkins Hosp 27:224–237 1916

    • Search Google Scholar
    • Export Citation
  • 13.

    Horrax G: Meningiomas of the brain. Arch Neurol Psychiatry 41:1401571939Horrax G: Meningiomas of the brain. Arch Neurol Psychiatry 41:140–157 1939

    • Search Google Scholar
    • Export Citation
  • 14.

    Hosoi K: Meningiomas. With special reference to the multiple intracranial type. Am J Pathol 6:2452601930Hosoi K: Meningiomas. With special reference to the multiple intracranial type. Am J Pathol 6:245–260 1930

    • Search Google Scholar
    • Export Citation
  • 15.

    Joynt RJPerret GE: Familial meningiomas. J Neurol Neurosurg Psychiatry 28:1631641965Joynt RJ Perret GE: Familial meningiomas. J Neurol Neurosurg Psychiatry 28:163–164 1965

    • Search Google Scholar
    • Export Citation
  • 16.

    Joynt RJPerret GE: Meningiomas in a mother and daughter. Cases without evidence of neurofibromatosis. Neurology 11:1641651961Joynt RJ Perret GE: Meningiomas in a mother and daughter. Cases without evidence of neurofibromatosis. Neurology 11:164–165 1961

    • Search Google Scholar
    • Export Citation
  • 17.

    Kanter WREldridge RFabricant Ret al: Central neurofibromatosis with bilateral acoustic neuroma: genetic, clinical and biochemical distinctions from periperal neurofibromatosis. Neurology 30:8518591980Kanter WR Eldridge R Fabricant R et al: Central neurofibromatosis with bilateral acoustic neuroma: genetic clinical and biochemical distinctions from periperal neurofibromatosis. Neurology 30:851–859 1980

    • Search Google Scholar
    • Export Citation
  • 18.

    Levin PGross SWMalis LIet al: Multiple intracranial meningiomas. Surg Gynecol Obstet 119:108510901964Levin P Gross SW Malis LI et al: Multiple intracranial meningiomas. Surg Gynecol Obstet 119:1085–1090 1964

    • Search Google Scholar
    • Export Citation
  • 19.

    Logue V: Surgery of meningiomas in Rob CSmith R (eds): Operative Surgery. Fundamental International Techniquesed 3. Head and Neck Vol 11. JSP Wilson editor. London/Boston: Butterworths1979 pp 128173Logue V: Surgery of meningiomas in Rob C Smith R (eds): Operative Surgery. Fundamental International Techniques ed 3. Head and Neck Vol 11. JSP Wilson editor. London/Boston: Butterworths 1979 pp 128–173

    • Search Google Scholar
    • Export Citation
  • 20.

    Lusins JONakagawa H: Multiple meningiomas evaluated by computed tomography. Neurosurgery 9:1371411981Lusins JO Nakagawa H: Multiple meningiomas evaluated by computed tomography. Neurosurgery 9:137–141 1981

    • Search Google Scholar
    • Export Citation
  • 21.

    Memon MY: Multiple and familial meningiomas without evidence of neurofibromatosis. Neurosurgery 7:2622641980Memon MY: Multiple and familial meningiomas without evidence of neurofibromatosis. Neurosurgery 7:262–264 1980

    • Search Google Scholar
    • Export Citation
  • 22.

    Mufson JADavidoff LM: Multiple meningiomas. Report of two cases. J Neurosurg 1:45571944Mufson JA Davidoff LM: Multiple meningiomas. Report of two cases. J Neurosurg 1:45–57 1944

    • Search Google Scholar
    • Export Citation
  • 23.

    Russell DSRubinstein LJ: Pathology of Tumours of the Nervous Systemed 4. London: Edward Arnold1977448 ppRussell DS Rubinstein LJ: Pathology of Tumours of the Nervous System ed 4. London: Edward Arnold 1977 448 pp

    • Search Google Scholar
    • Export Citation
  • 24.

    Schiffer JMundel GLahat Eet al: Multiple meningiomas in separate neuroaxial compartments in a child. Childs Brain 6:2812881980Schiffer J Mundel G Lahat E et al: Multiple meningiomas in separate neuroaxial compartments in a child. Childs Brain 6:281–288 1980

    • Search Google Scholar
    • Export Citation
  • 25.

    Schnegg JFGomez FLemarchand-Beraud Tet al: Presence of sex steroid hormone receptors in meningioma tissue. Surg Neurol 15:4154181981Schnegg JF Gomez F Lemarchand-Beraud T et al: Presence of sex steroid hormone receptors in meningioma tissue. Surg Neurol 15:415–418 1981

    • Search Google Scholar
    • Export Citation
  • 26.

    Simpson D: The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20:22391957Simpson D: The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20:22–39 1957

    • Search Google Scholar
    • Export Citation
  • 27.

    Vestergaard E: Multiple intracranial meningiomas. Acta Psychiatr Neurol 19:3894111944Vestergaard E: Multiple intracranial meningiomas. Acta Psychiatr Neurol 19:389–411 1944

    • Search Google Scholar
    • Export Citation
  • 28.

    Waga SMatsuda MHanda Het al: Multiple meningiomas. Report of four cases. J Neurosurg 37:3483511972Waga S Matsuda M Handa H et al: Multiple meningiomas. Report of four cases. J Neurosurg 37:348–351 1972

    • Search Google Scholar
    • Export Citation
  • 29.

    Winkelman NW: Post-operative seeding of the subarachnoid space and ventricles from a meningioma. J Neuropathol Exp Neurol 13:2602661954Winkelman NW: Post-operative seeding of the subarachnoid space and ventricles from a meningioma. J Neuropathol Exp Neurol 13:260–266 1954

    • Search Google Scholar
    • Export Citation
  • 30.

    Wishart JH: Case of tumours in the skull, dura mater and brain. Edinburgh Med Surg J 18:3933971822Wishart JH: Case of tumours in the skull dura mater and brain. Edinburgh Med Surg J 18:393–397 1822

    • Search Google Scholar
    • Export Citation
  • 31.

    Wood MWWhite RJKernohan JW: One hundred intracranial meningiomas found incidentally at necropsy. J Neuropathol Exp Neurol 16:3373401957Wood MW White RJ Kernohan JW: One hundred intracranial meningiomas found incidentally at necropsy. J Neuropathol Exp Neurol 16:337–340 1957

    • Search Google Scholar
    • Export Citation
  • 32.

    Worster-Drought CDickson WECMcMenemey WH: Multiple meningeal and perineural tumors with analogous changes in the glia and ependyma (neurofibroblastomatosis). Brain 60:851171937Worster-Drought C Dickson WEC McMenemey WH: Multiple meningeal and perineural tumors with analogous changes in the glia and ependyma (neurofibroblastomatosis). Brain 60:85–117 1937

    • Search Google Scholar
    • Export Citation
  • 33.

    Zervas NShintani AKallar Bet al: Multiple meningiomas occupying separate neuraxial compartments. Case report. J Neurosurg 33:2162201970Zervas N Shintani A Kallar B et al: Multiple meningiomas occupying separate neuraxial compartments. Case report. J Neurosurg 33:216–220 1970

    • Search Google Scholar
    • Export Citation
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