Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage

View More View Less
  • 1 Departments of Pediatrics, Neurology, Neurosurgery, and Gross Anatomy, Yale University School of Medicine, New Haven, Connecticut
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $515.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $612.00
Print or Print + Online

✓ Local cerebral glucose utilization has been measured by means of carbon-14 (14C)-autoradiography with 2-deoxyglucose in the newborn beagle puppy model of intraventricular hemorrhage. Our studies demonstrate gray matter/white matter differentiation of uptake of 14C-2-deoxyglucose in the control pups, as would be expected from adult animal studies. However, there is a marked homogeneity of 14C-2-deoxyglucose uptake in all brain regions in the puppies with intraventricular hemorrhage, possibly indicating a loss of the known coupling between cerebral blood flow and metabolism in this neuropathological condition.

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $515.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $612.00
  • 1.

    Cooke RWI, , Rolfe P, & Howat P: Apparent cerebral blood-flow in newborns with respiratory disease. Dev Med Child Neurol 21:154160, 1979 Cooke RWI, Rolfe P, Howat P: Apparent cerebral blood-flow in newborns with respiratory disease. Dev Med Child Neurol 21:154–160, 1979

    • Search Google Scholar
    • Export Citation
  • 2.

    Davies PA, & Tizard JPM: Very low birthweight and subsequent neurologic defect (with special reference to spastic diplegia). Dev Med Child Neurol 17:317, 1975 Davies PA, Tizard JPM: Very low birthweight and subsequent neurologic defect (with special reference to spastic diplegia). Dev Med Child Neurol 17:3–17, 1975

    • Search Google Scholar
    • Export Citation
  • 3.

    DeReuck J: The human periventricular arterial blood supply and the anatomy of cerebral infarctions. Eur Neurol 5:321334, 1971 DeReuck J: The human periventricular arterial blood supply and the anatomy of cerebral infarctions. Eur Neurol 5:321–334, 1971

    • Search Google Scholar
    • Export Citation
  • 4.

    Duffy TE, , Cavazzuit M, & Gregoire NM, et al: Regional cerebral glucose metabolism in newborn beagle dogs. Trans Am Soc Neurochem 10:171175, 1979 Duffy TE, Cavazzuit M, Gregoire NM, et al: Regional cerebral glucose metabolism in newborn beagle dogs. Trans Am Soc Neurochem 10:171–175, 1979

    • Search Google Scholar
    • Export Citation
  • 5.

    Dykes FD, , Lazzara A, & Ahmann P, et al: Intraventricular hemorrhage: a prospective evaluation of etiopathogenesis. Pediatrics 66:4249, 1980 Dykes FD, Lazzara A, Ahmann P, et al: Intraventricular hemorrhage: a prospective evaluation of etiopathogenesis. Pediatrics 66:42–49, 1980

    • Search Google Scholar
    • Export Citation
  • 6.

    Fein JM: Brain energetics and circulatory control after subarachnoid hemorrhage. J Neurosurg 45:498507, 1976 Fein JM: Brain energetics and circulatory control after subarachnoid hemorrhage. J Neurosurg 45:498–507, 1976

    • Search Google Scholar
    • Export Citation
  • 7.

    Fujimura M, , Salisbury DM, & Robinson RO, et al: Clinical events relating to intraventricular hemorrhage in the newborn. Arch Dis Child 54:409414, 1979 Fujimura M, Salisbury DM, Robinson RO, et al: Clinical events relating to intraventricular hemorrhage in the newborn. Arch Dis Child 54:409–414, 1979

    • Search Google Scholar
    • Export Citation
  • 8.

    Gardiner RM: Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the newborn calf and lamb. J Physiol (Lond) 305:357376, 1980 Gardiner RM: Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the newborn calf and lamb. J Physiol (Lond) 305:357–376, 1980

    • Search Google Scholar
    • Export Citation
  • 9.

    Goddard J, , Armstrong DL, & Michael LH: Regional cerebral blood flow in the beagle model of intraventricular hemorrhage during volume expansion following acute hemorrhagic hypotension. Ann Neurol 10:305, 1981 (Abstract) Goddard J, Armstrong DL, Michael LH: Regional cerebral blood flow in the beagle model of intraventricular hemorrhage during volume expansion following acute hemorrhagic hypotension. Ann Neurol 10:305, 1981 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 10.

    Goddard J, , Lewis RM, & Alcala H, et al: Intraventricular hemorrhage: an animal model. Ann Neurol 4:186, 1978 (Abstract) Goddard J, Lewis RM, Alcala H, et al: Intraventricular hemorrhage: an animal model. Ann Neurol 4:186, 1978 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 11.

    Goddard J, , Lewis RM, & Armstrong DL, et al: Moderate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle model. J Pediatr 96:10571060, 1980 Goddard J, Lewis RM, Armstrong DL, et al: Moderate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle model. J Pediatr 96:1057–1060, 1980

    • Search Google Scholar
    • Export Citation
  • 12.

    Goddard J, , Lewis RM, & Michael LH, et al: Preliminary studies of regional cerebral blood flow in hypovolemic and hypertensive newborn beagle pups. Ann Neurol 8:224225, 1980 (Abstract) Goddard J, Lewis RM, Michael LH, et al: Preliminary studies of regional cerebral blood flow in hypovolemic and hypertensive newborn beagle pups. Ann Neurol 8:224–225, 1980 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 13.

    Greenberg JH, , Nadasy G, & Kovach ABG, et al: Local cerebral glucose metabolism during hemorrhagic hypotension. J Cereb Blood Flow Metab 1 (Suppl 1): S254S255, 1981 Greenberg JH, Nadasy G, Kovach ABG, et al: Local cerebral glucose metabolism during hemorrhagic hypotension. J Cereb Blood Flow Metab 1 (Suppl 1):S254–S255, 1981

    • Search Google Scholar
    • Export Citation
  • 14.

    Guggenheim MA, , Rumack C, & Langendorfer S, et al: Risk factors in germinal matrix hemorrhage. Ann Neurol 8:225, 1980 (Abstract) Guggenheim MA, Rumack C, Langendorfer S, et al: Risk factors in germinal matrix hemorrhage. Ann Neurol 8:225, 1980 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 15.

    Hambleton G, & Wigglesworth JS: Origin of intraventricular haemorrhage in the preterm infant. Arch Dis Child 51:651659, 1976 Hambleton G, Wigglesworth JS: Origin of intraventricular haemorrhage in the preterm infant. Arch Dis Child 51:651–659, 1976

    • Search Google Scholar
    • Export Citation
  • 16.

    Hashi K, , Meyer JS, & Shinmaru S, et al: Cerebral hemodynamic and metabolic experimental subarachnoid hemorrhage. J Neurol Sci 17:114, 1972 Hashi K, Meyer JS, Shinmaru S, et al: Cerebral hemodynamic and metabolic experimental subarachnoid hemorrhage. J Neurol Sci 17:1–14, 1972

    • Search Google Scholar
    • Export Citation
  • 17.

    Hernández MJ, , Brennan RW, & Vannucci RC, et al: Cerebral blood flow and oxygen consumption in the newborn dog. Am J Physiol 234:R209R215, 1978 Hernández MJ, Brennan RW, Vannucci RC, et al: Cerebral blood flow and oxygen consumption in the newborn dog. Am J Physiol 234:R209–R215, 1978

    • Search Google Scholar
    • Export Citation
  • 18.

    Jones SC, , Fedora T, & Lear J, et al: The flow-metabolism couple in normal rat brain. J Cereb Blood Flow Metab 1 (Suppl 1): S488S489, 1981 Jones SC, Fedora T, Lear J, et al: The flow-metabolism couple in normal rat brain. J Cereb Blood Flow Metab 1 (Suppl 1):S488–S489, 1981

    • Search Google Scholar
    • Export Citation
  • 19.

    Kennedy C, , Grave GD, & Jehle JW, et al: Blood flow to white matter during maturation of the brain. Neurology 20:613618, 1970 Kennedy C, Grave GD, Jehle JW, et al: Blood flow to white matter during maturation of the brain. Neurology 20:613–618, 1970

    • Search Google Scholar
    • Export Citation
  • 20.

    Kennedy C, , Grave GD, & Jehle JW, et al: Changes in blood flow in the component structures of the dog brain during postnatal maturation. J Neurochem 19:24232433, 1972 Kennedy C, Grave GD, Jehle JW, et al: Changes in blood flow in the component structures of the dog brain during postnatal maturation. J Neurochem 19:2423–2433, 1972

    • Search Google Scholar
    • Export Citation
  • 21.

    Kennedy C, , Grave GD, & Jehle JW, et al: The regional circulation of the neonatal brain. Trans Am Neurol Assoc 94:286287, 1969 Kennedy C, Grave GD, Jehle JW, et al: The regional circulation of the neonatal brain. Trans Am Neurol Assoc 94:286–287, 1969

    • Search Google Scholar
    • Export Citation
  • 22.

    Kenny JD, , Garcia-Prats JA, & Hilliard JL, et al: Hypercarbia at birth: a possible role in the pathogenesis of intraventricular hemorrhage. Pediatrics 62:465467, 1978 Kenny JD, Garcia-Prats JA, Hilliard JL, et al: Hypercarbia at birth: a possible role in the pathogenesis of intraventricular hemorrhage. Pediatrics 62:465–467, 1978

    • Search Google Scholar
    • Export Citation
  • 23.

    Kjellmer I, , Karlsson K, & Olsson T, et al: Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res 8:5057, 1974 Kjellmer I, Karlsson K, Olsson T, et al: Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res 8:50–57, 1974

    • Search Google Scholar
    • Export Citation
  • 24.

    Krishnamoorthy KS, , Fernandez RA, & Momose KJ, et al: Evaluation of neonatal intracranial hemorrhage by computerized tomography. Pediatrics 59:165172, 1977 Krishnamoorthy KS, Fernandez RA, Momose KJ, et al: Evaluation of neonatal intracranial hemorrhage by computerized tomography. Pediatrics 59:165–172, 1977

    • Search Google Scholar
    • Export Citation
  • 25.

    Krishnamoorthy KS, , Rodres ID, & Huehnle KJ, et al: Neurologic sequelae in the survivors of neonatal intraventricular hemorrhage, in: Perinatal Intracranial Hemorrhage Conference Syllabus. Columbus, Ohio: Ross Laboratories, 1980, pp 697710 Krishnamoorthy KS, Rodres ID, Huehnle KJ, et al: Neurologic sequelae in the survivors of neonatal intraventricular hemorrhage, in: Perinatal Intracranial Hemorrhage Conference Syllabus. Columbus, Ohio: Ross Laboratories, 1980, pp 697–710

    • Search Google Scholar
    • Export Citation
  • 26.

    Mathew OP, , Bland HE, & Pickens JM, et al: Hypoglycorrhachia in the survivors of neonatal intracranial hemorrhage. Pediatrics 63:851854, 1979 Mathew OP, Bland HE, Pickens JM, et al: Hypoglycorrhachia in the survivors of neonatal intracranial hemorrhage. Pediatrics 63:851–854, 1979

    • Search Google Scholar
    • Export Citation
  • 27.

    Ment LR, , Scott DT, & Ehrenkranz RA, et al: 1250 grams birth weight neonates: prospective neurodevelopmental evaluation. Pediatrics (In press, 1982)Ment LR, Scott DT, Ehrenkranz RA, et al: 1250 grams birth weight neonates: prospective neurodevelopmental evaluation. Pediatrics (In press, 1982)

    • Search Google Scholar
    • Export Citation
  • 28.

    Ment LR, , Stewart WB, & Lambrecht R, et al: Local cerebral blood flow and metabolism in the beagle puppy model of intraventricular hemorrhage: an autoradiographic study. Ann Neurol 10:289, 1981 (Abstract) Ment LR, Stewart WB, Lambrecht R, et al: Local cerebral blood flow and metabolism in the beagle puppy model of intraventricular hemorrhage: an autoradiographic study. Ann Neurol 10:289, 1981 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 29.

    Milligan DWA: Failure of autoregulation and intraventricular haemorrhage in preterm infants. Lancet 1:896898, 1980 Milligan DWA: Failure of autoregulation and intraventricular haemorrhage in preterm infants. Lancet 1:896–898, 1980

    • Search Google Scholar
    • Export Citation
  • 30.

    Miyaoka M, , Shinohara M, & Kennedy C, et al: Alterations in local cerebral glucose utilization (LCGU) in rat brain during hypoxemia. Trans Am Neurol Assoc 104:151154, 1980 Miyaoka M, Shinohara M, Kennedy C, et al: Alterations in local cerebral glucose utilization (LCGU) in rat brain during hypoxemia. Trans Am Neurol Assoc 104:151–154, 1980

    • Search Google Scholar
    • Export Citation
  • 31.

    Papile LA, , Burstein J, & Burstein R, et al: Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 92:529534, 1978 Papile LA, Burstein J, Burstein R, et al: Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 92:529–534, 1978

    • Search Google Scholar
    • Export Citation
  • 32.

    Pasternak JF, , Groothuis DR, & Fischer JM: Regional cerebral blood flow in the awake newborn dog: the germinal matrix is a “low-flow” structure. Ann Neurol 10:283284, 1981 (Abstract) Pasternak JF, Groothuis DR, Fischer JM: Regional cerebral blood flow in the awake newborn dog: the germinal matrix is a “low-flow” structure. Ann Neurol 10:283–284, 1981 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 33.

    Plum F, , Posner JB, & Troy B: Cerebral metabolic and circulatory responses to induced convulsions in animals. Arch Neurol 18:113, 1968 Plum F, Posner JB, Troy B: Cerebral metabolic and circulatory responses to induced convulsions in animals. Arch Neurol 18:1–13, 1968

    • Search Google Scholar
    • Export Citation
  • 34.

    Pulsinelli WA, & Duffy TE: Local cerebral glucose metabolism during controlled hypoxemia in rats. Science 204:626629, 1979 Pulsinelli WA, Duffy TE: Local cerebral glucose metabolism during controlled hypoxemia in rats. Science 204:626–629, 1979

    • Search Google Scholar
    • Export Citation
  • 35.

    Savaki HE, , Macpherson H, & McCulloch J: Alterations in local cerebral glucose utilization during hemorrhagic hypotension. J Cereb Blood Flow Metab 1 (Suppl 1): S256S257, 1981 Savaki HE, Macpherson H, McCulloch J: Alterations in local cerebral glucose utilization during hemorrhagic hypotension. J Cereb Blood Flow Metab 1 (Suppl 1):S256–S257, 1981

    • Search Google Scholar
    • Export Citation
  • 36.

    Schechner S, , Ross G, & Auld P: Developmental follow-up at one year post-term of infants with intracranial hemorrhage, in: Perinatal Intracranial Hemorrhage Conference Syllabus. Columbus, Ohio: Ross Laboratories, 1980, pp 724735 Schechner S, Ross G, Auld P: Developmental follow-up at one year post-term of infants with intracranial hemorrhage, in: Perinatal Intracranial Hemorrhage Conference Syllabus. Columbus, Ohio: Ross Laboratories, 1980, pp 724–735

    • Search Google Scholar
    • Export Citation
  • 37.

    Silverboard G, , Horder MH, & Ahmann PA, et al: Reliability of ultrasound in diagnosis of intracerebral hemorrhage and posthemorrhagic hydrocephalus: comparison with computed tomography. Pediatrics 66:507514, 1980 Silverboard G, Horder MH, Ahmann PA, et al: Reliability of ultrasound in diagnosis of intracerebral hemorrhage and posthemorrhagic hydrocephalus: comparison with computed tomography. Pediatrics 66:507–514, 1980

    • Search Google Scholar
    • Export Citation
  • 38.

    Sokoloff L: Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1:736, 1981 Sokoloff L: Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1:7–36, 1981

    • Search Google Scholar
    • Export Citation
  • 39.

    Sokoloff L, , Reivich M, & Kennedy C, et al: The [14C]-deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897916, 1977 Sokoloff L, Reivich M, Kennedy C, et al: The [14C]-deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897–916, 1977

    • Search Google Scholar
    • Export Citation
  • 40.

    Swaab DF, & Boer K: The presence of biologically labile compounds during ischemia and their relationship to the EEG in rat cerebral cortex and hypothalamus. J Neurochem 19:28432853, 1972 Swaab DF, Boer K: The presence of biologically labile compounds during ischemia and their relationship to the EEG in rat cerebral cortex and hypothalamus. J Neurochem 19:2843–2853, 1972

    • Search Google Scholar
    • Export Citation
  • 41.

    Troost BT, , Walker JE, & Cherington M: Hypoglycorrhachia associated with subarachnoid hemorrhage. Arch Neurol 19:438442, 1968 Troost BT, Walker JE, Cherington M: Hypoglycorrhachia associated with subarachnoid hemorrhage. Arch Neurol 19:438–442, 1968

    • Search Google Scholar
    • Export Citation
  • 42.

    Vannucci RC, & Duffy TE: Cerebral metabolism in newborn dogs during reversible asphyxia. Ann Neurol 1:528534, 1977 Vannucci RC, Duffy TE: Cerebral metabolism in newborn dogs during reversible asphyxia. Ann Neurol 1:528–534, 1977

    • Search Google Scholar
    • Export Citation
  • 43.

    Vannucci RC, , Hellman J, & Dubynsky O, et al: Cerebral oxidative metabolism in perinatal post-hemorrhagic hydrocephalus. Dev Med Child Neurol 22:308316, 1980 Vannucci RC, Hellman J, Dubynsky O, et al: Cerebral oxidative metabolism in perinatal post-hemorrhagic hydrocephalus. Dev Med Child Neurol 22:308–316, 1980

    • Search Google Scholar
    • Export Citation
  • 44.

    Volpe JJ: Neonatal intracranial hemorrhage: pathophysiology, neuropathology, and clinical features. Clin Perinatol 4:77102, 1977 Volpe JJ: Neonatal intracranial hemorrhage: pathophysiology, neuropathology, and clinical features. Clin Perinatol 4:77–102, 1977

    • Search Google Scholar
    • Export Citation
  • 45.

    Wigglesworth JS, & Pape KE: An integrated model for haemorrhagic and ischaemic lesions in the newborn brain. Early Hum Dev 2:179199, 1978 Wigglesworth JS, Pape KE: An integrated model for haemorrhagic and ischaemic lesions in the newborn brain. Early Hum Dev 2:179–199, 1978

    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 339 74 2
Full Text Views 134 3 0
PDF Downloads 113 0 0
EPUB Downloads 0 0 0