Granular-cell pituicytoma associated with multiple endocrine neoplasia type 2

Case report

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✓ Granular-cell pituicytomas of the neurohypophysis have a controversial histogenesis and oncological behavior. The occurrence of such a tumor in a patient whose father and daughter had endocrine neoplasms suggests a neuroectodermal origin for these tumors. Although all of the conditions considered in this report are unusual clinical entities, their correlation offers considerations in understanding the importance of genetic factors in tumor development.

Article Information

Address reprint requests to: Joseph F. Cusick, M.D., Department of Neurosurgery, Medical College of Wisconsin, Milwaukee County Medical Complex, 8700 West Wisconsin Avenue, Milwaukee, Wisconsin 53226.

© AANS, except where prohibited by US copyright law.

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Figures

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    Contrast-enhanced computerized tomography scan, coronal projection, showing a homogeneously enhanced intrasellar mass with suprasellar extension. Opacification shown unilaterally in the sphenoid sinus represents chronic thickening of the mucosal membranes.

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    Photomicrograph of the tumor consisting of cells with abundant granular cytoplasm and small eccentric nuclei. H & E, × 12.5.

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