Statistical analysis of central nervous system tumors in China

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✓ The authors present a statistical survey of the general incidence, age distribution, and preferential sites of 25,122 tumors of the central nervous system (CNS), from 12 centers in China. Of these tumors, 22,457 were intracranial and the rest intraspinal.

Of the 22,457 intracranial neoplasms collected, tumors of neuroepithelial tissue comprised 43.85%, meningiomas 16.58%, tumors of nerve sheath cells 9.5%, pituitary adenoma 9.52%, congenital tumors 8.46%, secondary tumors 6.8%, vascular malformations and tumors 3.82%, and primary sarcomas 0.72%. Neuroepithelial and meningeal tumors occurred first and second in all series, but the other tumors varied in frequency. There was a higher incidence of nerve-sheath tumors in southern than in northern regions. The age distribution of Chinese patients with tumors of the CNS was lower than that of Caucasians: nearly two-thirds (64.57%) had the clinical onset of their tumor between the ages of 31 and 40 years, with the peak incidence at 35 years. Nearly 20% of tumors of the CNS occurred before 20 years of age. The male:female ratio was 1.53:1; the only tumor with a definite preponderance of females over males was the meningioma.

Intraspinal tumors derived from nerve sheaths comprised 47.13% of all tumors within the spinal canal. Meningiomas were second with an incidence of 14.06%, then followed congenital tumors (12.06%) and neoplasms of neuroepithelial tissue (10.83%). Secondary tumors, vascular malformations and neoplasms, and sarcoma were next in order of frequency with 4.6%, 4.5%, and 4.16%, respectively.

Article Information

Address for Xu Qing-zhong: Peking Neurosurgery Research Institute, Peking, China.

Address for Liu Zi-jun: Zhongshan Medical College, Guangzhou, China.

Address for Zhang Wen-cui: Chinese Medical College, Shenyang, China.

Address reprint requests to: A. Earl Walker, M.D., Division of Neurological Surgery, University of New Mexico, School of Medicine, Albuquerque, New Mexico 87131.

© AANS, except where prohibited by US copyright law.

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    Graphs showing the age distribution among patients with intracranial tumors. A: Age distribution of patients with astrocytomas, oligodendrogliomas, ependymomas, medulloblastomas, and glioblastomas. B: Age distribution of patients with meningiomas, nerve-sheath tumors, pituitary adenomas, and secondary tumors. C: Age distribution of patients with craniopharyngiomas, hemangioblastomas, and epidermoid and dermoid cysts.

References

1.

Alter M: Statistical aspects of spinal cord tumors in Vinken PJBruyn GW (eds): Tumours of the Spine and Spinal Cord Part I. Handbook of Clinical Neurology Vol 19. Amsterdam: North-Holland1975 pp 122Alter M: Statistical aspects of spinal cord tumors in Vinken PJ Bruyn GW (eds): Tumours of the Spine and Spinal Cord Part I. Handbook of Clinical Neurology Vol 19. Amsterdam: North-Holland 1975 pp 1–22

2.

Araki CMatsumoto S: Statistical reevaluation of pinealoma and related tumors in Japan. J Neurosurg 30:1461491969Araki C Matsumoto S: Statistical reevaluation of pinealoma and related tumors in Japan. J Neurosurg 30:146–149 1969

3.

Behrend RC: Epidemiology of brain tumours in Vinken PJBruyn GW (eds): Tumours of the Brain and Skull Part I. Handbook of Clinical Neurology Vol 16. Amsterdam: North-Holland1974 pp 5688 (see pp 56–58)Behrend RC: Epidemiology of brain tumours in Vinken PJ Bruyn GW (eds): Tumours of the Brain and Skull Part I. Handbook of Clinical Neurology Vol 16. Amsterdam: North-Holland 1974 pp 56–88 (see pp 56–58)

4.

Cushing HW: Intracranial Tumours. Notes Upon a Series of Two Thousand Verified Cases with Surgical-Mortality Percentages Pertaining Thereto. Springfield, Ill: Charles C Thomas1932150 ppCushing HW: Intracranial Tumours. Notes Upon a Series of Two Thousand Verified Cases with Surgical-Mortality Percentages Pertaining Thereto. Springfield Ill: Charles C Thomas 1932 150 pp

5.

Dastur DKLalitha VS: Pathological analysis of intracranial space-occupying lesions in 1000 cases including children. Part 2. Incidence, types and unusual cases of glioma. J Neurol Sci 8:1431701968Dastur DK Lalitha VS: Pathological analysis of intracranial space-occupying lesions in 1000 cases including children. Part 2. Incidence types and unusual cases of glioma. J Neurol Sci 8:143–170 1968

6.

Ding Yu-jiet al: Intracranial metastatic tumors in Wang Zhong Cheng (ed): Neurosurgery. Peking: People's Health Publisher1979 pp 380389Ding Yu-ji et al: Intracranial metastatic tumors in Wang Zhong Cheng (ed): Neurosurgery. Peking: People's Health Publisher 1979 pp 380–389

7.

General Hospital of the Chinese People's Liberation Armyet al (eds): Practical Neurosurgery. Peking: PLA Publisher1978 (see: Intracranial tumors pp 486–488; Intraspinal tumors pp 764–766)General Hospital of the Chinese People's Liberation Army et al (eds): Practical Neurosurgery. Peking: PLA Publisher 1978 (see: Intracranial tumors pp 486–488; Intraspinal tumors pp 764–766)

8.

Grant FC: A study of the results of surgical treatment in 2,326 consecutive patients with brain tumor. J Neurosurg 13:4794881956Grant FC: A study of the results of surgical treatment in 2326 consecutive patients with brain tumor. J Neurosurg 13:479–488 1956

9.

Huang Wen-qing: Pathology and Neural Tumors. Shanghai: Scientific and Technological Publisher1981 pp 2549Huang Wen-qing: Pathology and Neural Tumors. Shanghai: Scientific and Technological Publisher 1981 pp 25–49

10.

Jiang Yu-pinget al: Clinical manifestation and prognosis of brain metastasis. Chin J Neuropsychiatry 12:86901979Jiang Yu-ping et al: Clinical manifestation and prognosis of brain metastasis. Chin J Neuropsychiatry 12:86–90 1979

11.

Katsura SSuzuki JWada T: A statistical study of brain tumors in the neurosurgical clinics in Japan. J Neurosurg 16:5705801959Katsura S Suzuki J Wada T: A statistical study of brain tumors in the neurosurgical clinics in Japan. J Neurosurg 16:570–580 1959

12.

Kernohan JWSayre GP: Tumors of the central nervous system in: Atlas of Tumor Pathology Section X Fascicle 35. Washington, DC: Armed Forces Institute of Pathology1952Kernohan JW Sayre GP: Tumors of the central nervous system in: Atlas of Tumor Pathology Section X Fascicle 35. Washington DC: Armed Forces Institute of Pathology 1952

13.

Kurland LTMyrianthopoulos NCLessell J: Epidemiologic and genetic considerations of the intracranial neoplasms in Fields WSSharkey PC (eds): The Biology and Treatment of Intracranial Tumors. Springfield, Ill: Charles C Thomas1962 pp 548Kurland LT Myrianthopoulos NC Lessell J: Epidemiologic and genetic considerations of the intracranial neoplasms in Fields WS Sharkey PC (eds): The Biology and Treatment of Intracranial Tumors. Springfield Ill: Charles C Thomas 1962 pp 5–48

14.

Leibowitz UAlter M: Tumors of the nervous system—incidence and population selectivity. Neurology 19:2921969 (Abstract)Leibowitz U Alter M: Tumors of the nervous system—incidence and population selectivity. Neurology 19:292 1969 (Abstract)

15.

Liang Chen-ganget al: A brief survey of 681 cases brain tumor in Guang Xi Medical College (ed): Surgical Theses Vol 1. 1978 pp 1417Liang Chen-gang et al: A brief survey of 681 cases brain tumor in Guang Xi Medical College (ed): Surgical Theses Vol 1. 1978 pp 14–17

16.

Li Binget al: The distribution and mortality of malignant tumors in China. Chin J Oncol 2:1101980Li Bing et al: The distribution and mortality of malignant tumors in China. Chin J Oncol 2:1–10 1980

17.

Li Qong-binYang Shu-yuan: Intraspinal tumor in Yang Lu Chun (ed): Practical Neurology. Tian Jin: People's Publisher1976 pp 339344Li Qong-bin Yang Shu-yuan: Intraspinal tumor in Yang Lu Chun (ed): Practical Neurology. Tian Jin: People's Publisher 1976 pp 339–344

18.

Liu Yong-jiZai Yun-chang: Some key therapeutic points in the treatment of various kinds of intraspinal tumors. Chin J Neuropsychiatry 9:48511965Liu Yong-ji Zai Yun-chang: Some key therapeutic points in the treatment of various kinds of intraspinal tumors. Chin J Neuropsychiatry 9:48–51 1965

19.

Liu Zi-junet al.: A pathological analysis of 964 cases of CNS tumors. J Tumor Prevention Treat 6:16211979Liu Zi-jun et al.: A pathological analysis of 964 cases of CNS tumors. J Tumor Prevention Treat 6:16–21 1979

20.

Oddsson B: Spinal Meningioma. Copenhagen: Munksgaard1947Oddsson B: Spinal Meningioma. Copenhagen: Munksgaard 1947

21.

Olivecrona H: Die arteriovenosen Aneurysmen des Gehirns. Dtsch Med Wochenschr 75:116911731950Olivecrona H: Die arteriovenosen Aneurysmen des Gehirns. Dtsch Med Wochenschr 75:1169–1173 1950

22.

Percy AK: Neoplasms of the central nervous system: epidemiologic considerations. Neurology 20:3983991970 (Abstract)Percy AK: Neoplasms of the central nervous system: epidemiologic considerations. Neurology 20:398–399 1970 (Abstract)

23.

Percy AKElveback LROkazaki Het al: Neoplasms of the central nervous system: epidemiologic considerations. Neurology 22:40481972Percy AK Elveback LR Okazaki H et al: Neoplasms of the central nervous system: epidemiologic considerations. Neurology 22:40–48 1972

24.

Rand CW: Surgical experiences with spinal cord tumors. A survey over a forty-year period. Bull Los Angeles Neurol Soc 28:2602681963Rand CW: Surgical experiences with spinal cord tumors. A survey over a forty-year period. Bull Los Angeles Neurol Soc 28:260–268 1963

25.

Razdlovsky EY: Tumors of the Brain. Moscow: Izdatelstvo “Meditsina,” 1954 pp 1220712–13 206–207Razdlovsky EY: Tumors of the Brain. Moscow: Izdatelstvo “Meditsina” 1954 pp 12–13 206–207

26.

Research Group in Neurosurgery Department Jilin Medical University: Practical Neurosurgery. Jilin: People's Publisher1977 pp 298310Research Group in Neurosurgery Department Jilin Medical University: Practical Neurosurgery. Jilin: People's Publisher 1977 pp 298–310

27.

Russell DSRubinstein LJ: Pathology of Tumours of the Nervous Systemed 4. London: Edward Arnold1977448 ppRussell DS Rubinstein LJ: Pathology of Tumours of the Nervous System ed 4. London: Edward Arnold 1977 448 pp

28.

Sano K: [Statistics on brain tumors and glioma.] No To Shinkei 21:4634651969(Jap)Sano K: [Statistics on brain tumors and glioma.] No To Shinkei 21:463–465 1969 (Jap)

29.

Shanghai First Medical College: Lectures in Surgical Pathology.. 1977 pp 371399Shanghai First Medical College: Lectures in Surgical Pathology. 1977 pp 371–399

30.

Shi Yu-quan: An analysis of 30 surgical cases of intraspinal tumor. Chin J Neuropsychiatry 1:1071141955Shi Yu-quan: An analysis of 30 surgical cases of intraspinal tumor. Chin J Neuropsychiatry 1:107–114 1955

31.

Shuangshoti SPanyathanya R: Neural neoplasms in Thailand: a study of 2,897 cases. Neurology 24:112711341974Shuangshoti S Panyathanya R: Neural neoplasms in Thailand: a study of 2897 cases. Neurology 24:1127–1134 1974

32.

Si Li-shenget al: Pathological analysis of 800 cases of CNS tumors. J Xi An Med Coll 2:1141211975Si Li-sheng et al: Pathological analysis of 800 cases of CNS tumors. J Xi An Med Coll 2:114–121 1975

33.

Slooff JLKernohan JWMacCarty CS: Primary Intramedullary Tumors of the Spinal Cord and Filum Terminale. Philadelphia/London: WB Saunders1964Slooff JL Kernohan JW MacCarty CS: Primary Intramedullary Tumors of the Spinal Cord and Filum Terminale. Philadelphia/London: WB Saunders 1964

34.

Song Yu-lunet al: A pathological analysis of 1,309 cases of CNS tumors in: Proceedings of Pathology Seminar in North-East China. Ha Er Bin Medical University1979Song Yu-lun et al: A pathological analysis of 1309 cases of CNS tumors in: Proceedings of Pathology Seminar in North-East China. Ha Er Bin Medical University 1979

35.

Sun Si-fanget al: Surgical treatment of brain metastases in: Selected Papers of Medical Science. Institute of Medical Sciences of North-East China1978 pp 5356Sun Si-fang et al: Surgical treatment of brain metastases in: Selected Papers of Medical Science. Institute of Medical Sciences of North-East China 1978 pp 53–56

36.

World Health Organization:Histological classification of tumors of the central nervous system. Bull Los Angeles Neurol Soc 42:771977World Health Organization: Histological classification of tumors of the central nervous system. Bull Los Angeles Neurol Soc 42:77 1977

37.

Xu Qing-zhong: The pathology of intracranial tumor in Wang Zhong Cheng (ed): NeurosurgeryPart 2. Peking: People's Health Publisher1979 pp 723Xu Qing-zhong: The pathology of intracranial tumor in Wang Zhong Cheng (ed): Neurosurgery Part 2. Peking: People's Health Publisher 1979 pp 7–23

38.

Xu Qing-zhong: Statistical analysis of 6400 intracranial tumors and 710 intraspinal tumors in: Practical Oncology. Peking: People's Health Publisher (In press)Xu Qing-zhong: Statistical analysis of 6400 intracranial tumors and 710 intraspinal tumors in: Practical Oncology. Peking: People's Health Publisher (In press)

39.

Yang Shu-yuanet al: Intracranial tumor in Yang Lu Chun (ed): Practical Neurology. Tian Jin: People's Publisher1976 pp 219257Yang Shu-yuan et al: Intracranial tumor in Yang Lu Chun (ed): Practical Neurology. Tian Jin: People's Publisher 1976 pp 219–257

40.

Yaso T: Brain Tumors. Tokyo: Medicine Publisher1959 pp 100158Yaso T: Brain Tumors. Tokyo: Medicine Publisher 1959 pp 100–158

41.

Yin Zhao-yan: The diagnosis and treatment of intraspinal tumor. Chin J Surg 10:3683731962Yin Zhao-yan: The diagnosis and treatment of intraspinal tumor. Chin J Surg 10:368–373 1962

42.

Ying Yue-yinget al: Primary intracranial and intraspinal tumor (with pathological analysis of 400 cases. Proceedings of the National Symposium on Tumor1959. Peking: People's Health Publisher1960 pp 757761Ying Yue-ying et al: Primary intracranial and intraspinal tumor (with pathological analysis of 400 cases.) Proceedings of the National Symposium on Tumor 1959. Peking: People's Health Publisher 1960 pp 757–761

43.

Zhang Fu-lin: The incidence rate of CNS tumors (pathology of 4,541 cases. New Med (Suppl) Dis Nerv System 1:141978Zhang Fu-lin: The incidence rate of CNS tumors (pathology of 4541 cases.) New Med (Suppl) Dis Nerv System 1:1–4 1978

44.

Zhang Fu-lin: Some suggestions regarding the nomenclature and classification of gliomas. New Med (Suppl) Dis Nerv System 1:4101978Zhang Fu-lin: Some suggestions regarding the nomenclature and classification of gliomas. New Med (Suppl) Dis Nerv System 1:4–10 1978

45.

Zhang Wen-cui: Statistical analysis of 1,192 cases of intracranial tumors in: Concise Neurology. Liaoning: People's Publisher1981 pp 120Zhang Wen-cui: Statistical analysis of 1192 cases of intracranial tumors in: Concise Neurology. Liaoning: People's Publisher 1981 pp 1–20

46.

Zhao Yi-cheng: Analysis of 1,047 cases of intracranial tumor. Chin J Surg 9:1821841961Zhao Yi-cheng: Analysis of 1047 cases of intracranial tumor. Chin J Surg 9:182–184 1961

47.

Zhou Bing-wenet al: Primary intraspinal tumor (with analysis of 50 surgical cases. J Qing Dao Med Univ 1:19221976Zhou Bing-wen et al: Primary intraspinal tumor (with analysis of 50 surgical cases.) J Qing Dao Med Univ 1:19–22 1976

48.

Zülch KJ: Brain Tumors: Their Biology and Their Pathologyed 2. New York: Springer-Verlag1965 pp 6288Zülch KJ: Brain Tumors: Their Biology and Their Pathology ed 2. New York: Springer-Verlag 1965 pp 62–88

49.

Zülch KJ: Principles of the new World Health Organization (WHO) classification of brain tumors. Neuroradiology 19:59661980Zülch KJ: Principles of the new World Health Organization (WHO) classification of brain tumors. Neuroradiology 19:59–66 1980

50.

Zülch KJMennel HD: The biology of brain tumours in Vinken PJBruyn GW (eds): Tumours of the Brain and Skull Part I. Handbook of Clinical Neurology Vol 16. Amsterdam: North-Holland1974 pp 155Zülch KJ Mennel HD: The biology of brain tumours in Vinken PJ Bruyn GW (eds): Tumours of the Brain and Skull Part I. Handbook of Clinical Neurology Vol 16. Amsterdam: North-Holland 1974 pp 1–55

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