Pubertas praecox in craniopharyngioma

Case report

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✓ A case of craniopharyngioma associated with true precocious puberty is reported in a child operated on when she was 2 years and 8 months of age. Precocity was noted 10 months after operation and was fully documented 1 year later. A pneumoencephalogram showed a recurrence of tumor in the hypothalamic area. Hormonal therapy was instituted to stop sexual maturation. Reoperation was undertaken only when her visual symptoms reappeared. She received a postoperative course of radiotherapy. On last examination, she was neurologically well, and computerized tomography did not show further growth of the residual tumor. The diagnosis of precocious puberty and its etiology in this patient are discussed.

Article Information

Address reprint requests to: José M. Cabezudo, M.D., Servicio de Neurocirugia, Clinica Puerta de Hierro, San Martin de Porres 4, Madrid 35, Spain.

© AANS, except where prohibited by US copyright law.

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Figures

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    Preoperative pneumoencephalogram, lateral view. The suprasellar tumor can be seen filling the third ventricle from below.

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    Preoperative air ventriculogram, lateral view. The third ventricle fills only in its anterior part due to the tumor impinging upon it from below.

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    Photomicrograph of the surgical specimen showing the typical epithelial pattern of craniopharyngioma. H & E, × 175.

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    Pneumoencephalogram showing recurrence of the tumor. The suprasellar cistern is free, but the anterior recesses of the third ventricle do not fill due to tumoral impingement upon them.

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    Computerized tomographic scan in May, 1978, showing cystic and calcified recurrent tumor.

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