Cellolite (Merocel): a new form of neurosurgical patty

Evaluation of histological responses in rats

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✓ Cellolite and cottonoid were compared with regard to histological reactions provoked when they were left in contact with the rat brain. Pieces of each material were implanted in 27 rats either extra- or intracerebrally for 48 hours or 28 days. Histological findings suggest that the use of Cellolite for neurosurgery would be unlikely to cause adverse reactions any worse than those caused by cottonoid.

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Address reprint requests to: Carl H. A. Meyer, F.R.A.C.S., Department of Neurosurgery, Brook General Hospital, London S.E. 18, England.

© AANS, except where prohibited by US copyright law.

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    Cross sections of the implantation sites. The hole in the sections indicates the right side of the specimen. Cellolite is indicated by the single arrowhead, and cottonoid by the double arrowhead. For microscopic description see text. Upper Left: Group 1 rat brain shows a bilateral superficial cortical depression. Luxol fast blue, × 5.5. Upper Right: Group 2 rat brain shows greater disruption associated with cottonoid. Luxol fast blue, × 5.5. Lower Left: Group 3 rat brain shows a patch of chronic granulomatous reaction to cottonoid. Luxol fast blue, × 5.5. Lower Right: Group 4 rat brain. The cavity about the cottonoid is larger than that about the Cellolite. H & E, × 8.

References

1.

American Society for Testing and Materials (ASTM): Standard Practice for Assessment of Compatibility of Non-porous Polymeric Materials for Surgical Implants with Regard to Effects of Materials to Tissues. ASTM/ANSI F469-78. 1978 pp 711713American Society for Testing and Materials (ASTM): Standard Practice for Assessment of Compatibility of Non-porous Polymeric Materials for Surgical Implants with Regard to Effects of Materials to Tissues. ASTM/ANSI F469-78. 1978 pp 711–713

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