The effect of dexamethasone on the rate of formation of cerebrospinal fluid in the monkey

Albert N. Martins LtC USA MC1, Archimedes Ramirez Maj USA MC1, Lewis S. Solomon M.D.1, and G. Michael Wiese Maj USA MC1
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  • 1 Neurosurgery Service, Walter Reed Army Medical Center, Washington, D.C., and Neurobiology Division, Armed Forces Radiobiology Research Institute, Bethesda, Maryland
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✓ The standard ventriculocisternal perfusion technique was used to determine what effect a single large intravenous dose of dexamethasone would have on CSF formation rate in the rhesus monkey over a 4-hour period. Three monkeys received 0.15 mg/kg, four received 0.4 mg/kg and five served as the untreated controls. With time, CSF formation rates decreased in both treated and control groups. The magnitude of the decrease in the treated and untreated controls did not differ significantly. We conclude that the therapeutic benefit of dexamethasone for intracranial spatial decompensation derives from a mechanism of action that leaves the rate of CSF formation unchanged.

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