Intracranial pressure in conscious rabbits after intraventricular reserpine

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✓ Ventricular fluid pressure was measured continuously for 50 hours in conscious rabbits via a cannula implanted into the left lateral ventricle. Intraventricular injection of 25 µg reserpine (in a volume of 10 µl) resulted in increased pressure compared to that in non-injected controls during the first 7 to 10 hours. This was interpreted as depletion of noradrenaline in intracranial sympathetic nerves leading to increased cerebral blood volume and increased cerebrospinal fluid production. During the remainder of the experiment, the ventricular fluid pressure was reduced, probably due to a predominance of the central depressant effects of reserpine.

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Address reprint requests to: Professor Christer Owman, M.D., Department of Histology, Biskopsgatan 5, S-223 62 Lund, Sweden.

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References
  • 1.

    Bein HJ: Effects of reserpine on the functional strata of the nervous system in Garattini SGhetti V (eds): Psychotropic Drugs. AmsterdamElsevier Publishing Co1957 pp 325331Bein HJ: Effects of reserpine on the functional strata of the nervous system in Garattini S Ghetti V (eds): Psychotropic Drugs. Amsterdam Elsevier Publishing Co 1957 pp 325–331

    • Search Google Scholar
    • Export Citation
  • 2.

    Carlsson A: Drugs which block the storage of 5-hydroxytryptamine and related amines in ErspamerV (ed): Handbook of Experimental Pharmacology Vol 19: 5-Hydroxytryptamine and Related Indolealkylamines. Berlin-Heidelberg-New YorkSpringer Verlag1965 pp 529592Carlsson A: Drugs which block the storage of 5-hydroxytryptamine and related amines in Erspamer V (ed): Handbook of Experimental Pharmacology Vol 19: 5-Hydroxytryptamine and Related Indolealkylamines. Berlin-Heidelberg-New York Springer Verlag 1965 pp 529–592

    • Search Google Scholar
    • Export Citation
  • 3.

    Dasgupta SRHaley TJ: Intraventricular administration of reserpine and its metabolites to conscious cats. Brit J Pharmacol 12:5295311957Dasgupta SR Haley TJ: Intraventricular administration of reserpine and its metabolites to conscious cats. Brit J Pharmacol 12:529–531 1957

    • Search Google Scholar
    • Export Citation
  • 4.

    Edvinsson LHakåson ROwman Cet al: Sympathetic influence on carbanhydrase activity in choroid plexus. Exp Cell Res 67:2451971Edvinsson L Hakåson R Owman C et al: Sympathetic influence on carbanhydrase activity in choroid plexus. Exp Cell Res 67:245 1971

    • Search Google Scholar
    • Export Citation
  • 5.

    Edvinsson LNielsen KCOwman C: Sympathetic nervous influence on the blood circulation and carbonic anhydrase activity in the choroid plexus. Stroke 4:3681973Edvinsson L Nielsen KC Owman C: Sympathetic nervous influence on the blood circulation and carbonic anhydrase activity in the choroid plexus. Stroke 4:368 1973

    • Search Google Scholar
    • Export Citation
  • 6.

    Edvinsson LNielsen KCOwman Cet al: Adrenergic innervation of mammalian choroid plexus. Amer J Anat 139:2993081974Edvinsson L Nielsen KC Owman C et al: Adrenergic innervation of mammalian choroid plexus. Amer J Anat 139:299–308 1974

    • Search Google Scholar
    • Export Citation
  • 7.

    Edvinsson LNielsen KCOwman Cet al: Alterations in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals. Acta Physiol Scand 82:5275311971aEdvinsson L Nielsen KC Owman C et al: Alterations in intracranial pressure blood-brain barrier and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals. Acta Physiol Scand 82:527–531 1971a

    • Search Google Scholar
    • Export Citation
  • 8.

    Edvinsson LNielsen KCOwman Cet al: Evidence of vasoconstrictor sympathetic nerves in brain vessels of mice. Neurology (Minneap) 23:73771973Edvinsson L Nielsen KC Owman C et al: Evidence of vasoconstrictor sympathetic nerves in brain vessels of mice. Neurology (Minneap) 23:73–77 1973

    • Search Google Scholar
    • Export Citation
  • 9.

    Edvinsson LNielsen KCOwman Cet al: Increase in kaolin-induced intracranial hypertension after decentralization of the superior cervical sympathetic ganglia in rabbits. Eur Neurol (In press)Edvinsson L Nielsen KC Owman C et al: Increase in kaolin-induced intracranial hypertension after decentralization of the superior cervical sympathetic ganglia in rabbits. Eur Neurol (In press)

    • Search Google Scholar
    • Export Citation
  • 10.

    Edvinsson LNielsen KCOwman Cet al: Sympathetic adrenergic influence on brain vessels as studied by changes in cerebral blood volume of mice. Eur Neurol 6:1932021971–72Edvinsson L Nielsen KC Owman C et al: Sympathetic adrenergic influence on brain vessels as studied by changes in cerebral blood volume of mice. Eur Neurol 6:193–202 1971–72

    • Search Google Scholar
    • Export Citation
  • 11.

    Edvinsson LOwman CWest KA: Changes in continuously recorded intracranial pressure of conscious rabbits at different time-periods after superior cervical sympathectomy. Acta Physiol Scand 83:42501971Edvinsson L Owman C West KA: Changes in continuously recorded intracranial pressure of conscious rabbits at different time-periods after superior cervical sympathectomy. Acta Physiol Scand 83:42–50 1971

    • Search Google Scholar
    • Export Citation
  • 12.

    Edvinsson LOwman CWest KA: Intracranial pressure in conscious rabbits after decentralization of the superior sympathetic ganglia. Acta Physiol Scand 85:1932001972Edvinsson L Owman C West KA: Intracranial pressure in conscious rabbits after decentralization of the superior sympathetic ganglia. Acta Physiol Scand 85:193–200 1972

    • Search Google Scholar
    • Export Citation
  • 13.

    Edvinsson LOwman CWest KA: Modification of kaolin-induced intracranial hypertension at various time-periods after superior cervical sympathectomy in rabbits. Acta Physiol Scand 83:51591971Edvinsson L Owman C West KA: Modification of kaolin-induced intracranial hypertension at various time-periods after superior cervical sympathectomy in rabbits. Acta Physiol Scand 83:51–59 1971

    • Search Google Scholar
    • Export Citation
  • 14.

    Fleming WWTrendelenburg U: Development of supersensitivity to norepinephrine after pretreatment with reserpine. J Pharmacol Exp Ther 133:41511961Fleming WW Trendelenburg U: Development of supersensitivity to norepinephrine after pretreatment with reserpine. J Pharmacol Exp Ther 133:41–51 1961

    • Search Google Scholar
    • Export Citation
  • 15.

    Lindmar RMuscholl E: Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsflüssigkeit und die Noradrenalinaufnahme in das isolierte Herz. Arch Exp Path Pharmak 247:4694921964Lindmar R Muscholl E: Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsflüssigkeit und die Noradrenalinaufnahme in das isolierte Herz. Arch Exp Path Pharmak 247:469–492 1964

    • Search Google Scholar
    • Export Citation
  • 16.

    Nielsen KCOwman C: Adrenergic innervation of pial arteries related to the circle of Willis in the cat. Brain Res 6:7737761967Nielsen KC Owman C: Adrenergic innervation of pial arteries related to the circle of Willis in the cat. Brain Res 6:773–776 1967

    • Search Google Scholar
    • Export Citation
  • 17.

    Owman CWest KA: Effect of superior cervical sympathectomy on experimentally induced intracranial hypertension. Brain Res 18:4694761970Owman C West KA: Effect of superior cervical sympathectomy on experimentally induced intracranial hypertension. Brain Res 18:469–476 1970

    • Search Google Scholar
    • Export Citation
  • 18.

    Peerless SJYasargil MG: Adrenergic innervation of the cerebral blood vessels in the rabbit. J Neurosurg 35:1481541971Peerless SJ Yasargil MG: Adrenergic innervation of the cerebral blood vessels in the rabbit. J Neurosurg 35:148–154 1971

    • Search Google Scholar
    • Export Citation
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