Clinicopathological study of 53 tumors of the pineal region

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✓ Fifty-three cases of pineal and posterior-third ventricular tumors seen at the Massachusetts General Hospital from 1920 to 1972 are reviewed. This series includes 35 pathologically verified tumors and 18 cases accepted as pineal neoplasms on clinical and radiographic grounds. A plan of management is proposed based on a correlation between the clinical and pathological features and the response of each type of tumor to the currently available modes of therapy.

Article Information

Address reprint requests to: Henry Schmidek, M.D., Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114.

© AANS, except where prohibited by US copyright law.

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Figures

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    Germinoma. The tumor cell has a rounded vesicular nucleus, a prominent nucleolus, and a clear cytoplasm with distinct cytoplasmic borders. H & E, X 1500.

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    Pineocytoma. The tumor bears a striking resemblance to the normal pineal gland. H & E, X 180.

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    Pineoblastoma. The tumor is composed of sheets of highly malignant cells. H & E, X 700.

References

  • 1.

    Bloom HJGWallace ENKHenk JM: The treatment and prognosis of medulloblastoma in children: a study of 82 verified cases. Am J Roentgen 105:43621969Bloom HJG Wallace ENK Henk JM: The treatment and prognosis of medulloblastoma in children: a study of 82 verified cases. Am J Roentgen 105:43–62 1969

    • Search Google Scholar
    • Export Citation
  • 2.

    Cummins FMTaveras JMSchlesinger EB: Treatment of gliomas of the third ventricle and pinealomas: with special reference to the value of radiotherapy. Neurology 10:103110361960Cummins FM Taveras JM Schlesinger EB: Treatment of gliomas of the third ventricle and pinealomas: with special reference to the value of radiotherapy. Neurology 10:1031–1036 1960

    • Search Google Scholar
    • Export Citation
  • 3.

    Dandy WE: An operation for the removal of pineal tumors. Surg Gynec Obstet 33:1131191921Dandy WE: An operation for the removal of pineal tumors. Surg Gynec Obstet 33:113–119 1921

    • Search Google Scholar
    • Export Citation
  • 4.

    Dayan ADMarshall AHMiller AAet al: Atypical teratomas of the pineal and hypothalamus. J Path Bact 92:1281966Dayan AD Marshall AH Miller AA et al: Atypical teratomas of the pineal and hypothalamus. J Path Bact 92:1–28 1966

    • Search Google Scholar
    • Export Citation
  • 5.

    DeGirolami UZvaigzne O: Modification of the Achucharro-Hortega pineal stain for paraffin-embedded formalin fixed tissue. Stain Tech 48:48501973DeGirolami U Zvaigzne O: Modification of the Achucharro-Hortega pineal stain for paraffin-embedded formalin fixed tissue. Stain Tech 48:48–50 1973

    • Search Google Scholar
    • Export Citation
  • 6.

    Jamieson KG: Excision of pineal tumors. J Neurosurg 35:5505531971Jamieson KG: Excision of pineal tumors. J Neurosurg 35:550–553 1971

    • Search Google Scholar
    • Export Citation
  • 7.

    Lindgren M: On tolerance of brain tissue and sensitivity of brain tumours to irradiation. Acta Radiol Suppl 170:1731958Lindgren M: On tolerance of brain tissue and sensitivity of brain tumours to irradiation. Acta Radiol Suppl 170:1–73 1958

    • Search Google Scholar
    • Export Citation
  • 8.

    Rand RWLemmen LJ: Tumors of the posterior portion of the third ventricle. J Neurosurg 10:1181953Rand RW Lemmen LJ: Tumors of the posterior portion of the third ventricle. J Neurosurg 10:1–18 1953

    • Search Google Scholar
    • Export Citation
  • 9.

    Rubinstein LJ: Tumors of the central nervous system in: Atlas of Tumor Pathology. Washington, D CArmed Forces Institute of Pathology1972Rubinstein LJ: Tumors of the central nervous system in: Atlas of Tumor Pathology. Washington D C Armed Forces Institute of Pathology 1972

    • Search Google Scholar
    • Export Citation
  • 10.

    Russell D: The pinealoma: its relationship to teratoma. J Path Bact 56:1451501944Russell D: The pinealoma: its relationship to teratoma. J Path Bact 56:145–150 1944

    • Search Google Scholar
    • Export Citation
  • 11.

    Russell DRubinstein L: Pathology of Tumours of the Nervous System. LondonE Arnold1971ed 3 pp 208220Russell D Rubinstein L: Pathology of Tumours of the Nervous System. London E Arnold 1971 ed 3 pp 208–220

    • Search Google Scholar
    • Export Citation
  • 12.

    Schulz MDWang CCZinninger GFet al: Radiotherapy of intracranial neoplasms. Prog Neurol Surg 2:3183701968Schulz MD Wang CC Zinninger GF et al: Radiotherapy of intracranial neoplasms. Prog Neurol Surg 2:318–370 1968

    • Search Google Scholar
    • Export Citation
  • 13.

    Stein BM: The intratentorial supracerebellar approach to pineal lesions. J Neurosurg 35:1972021971Stein BM: The intratentorial supracerebellar approach to pineal lesions. J Neurosurg 35:197–202 1971

    • Search Google Scholar
    • Export Citation
  • 14.

    Suzuki JIwabuchi T: Surgical removal of pineal tumors (pinealomas and teratomas). Experience in a series of 19 cases. J Neurosurg 23:5655711965Suzuki J Iwabuchi T: Surgical removal of pineal tumors (pinealomas and teratomas). Experience in a series of 19 cases. J Neurosurg 23:565–571 1965

    • Search Google Scholar
    • Export Citation

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