Treatment of cerebral vasospasm from subarachnoid hemorrhage with isoproterenol and lidocaine hydrochloride

Restricted access

✓ Initial experience with intravenously administered isoproterenol and lidocaine hydrochloride in 14 patients with severe spasm from subarachnoid hemorrhage is summarized. All patients were actively deteriorating from progressive spasm without other major complications; 12 of 14 improved, and two died. The method of treatment, results, and rationale for this method of therapy are discussed.

Article Information

Address reprint requests to: Thoralf M. Sundt, Jr., M.D., Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.

© AANS, except where prohibited by US copyright law.

Headings

References

  • 1.

    Botterell EHLougheed WMScott JWet al: Hypothermia, and interruption of carotid, or carotid and vertebral circulation, in the surgical management of intracranial aneurysms. J Neurosurg 13:1421956Botterell EH Lougheed WM Scott JW et al: Hypothermia and interruption of carotid or carotid and vertebral circulation in the surgical management of intracranial aneurysms. J Neurosurg 13:1–42 1956

  • 2.

    Falck BMchedlishvili GIOwman C: Histochemical demonstration of adrenergic nerves in the cortex-pia of rabbit. Acta Pharmacol Toxicol (Kbh) 23:1331421965Falck B Mchedlishvili GI Owman C: Histochemical demonstration of adrenergic nerves in the cortex-pia of rabbit. Acta Pharmacol Toxicol (Kbh) 23:133–142 1965

  • 3.

    Fraser RARStein BMBarrett REet al: Noradrenergic mediation of experimental cerebrovascular spasm. Stroke 1:3563621970Fraser RAR Stein BM Barrett RE et al: Noradrenergic mediation of experimental cerebrovascular spasm. Stroke 1:356–362 1970

  • 4.

    Garrett HE: Personal communication1968Garrett HE: Personal communication 1968

  • 5.

    Lewis CMWeil MH: Hemodynamic spectrum of vasopressor and vasodilator drugs. JAMA 208:139113981969Lewis CM Weil MH: Hemodynamic spectrum of vasopressor and vasodilator drugs. JAMA 208:1391–1398 1969

  • 6.

    Lowe RFGilboe DD: Demonstration of alpha and beta adrenergic receptors in canine cerebral vasculature. Stroke 2:1932001971Lowe RF Gilboe DD: Demonstration of alpha and beta adrenergic receptors in canine cerebral vasculature. Stroke 2:193–200 1971

  • 7.

    Nelson ERennels M: Innervation of intracranial arteries. Brain 93:4754901970Nelson E Rennels M: Innervation of intracranial arteries. Brain 93:475–490 1970

  • 8.

    Peerless SJYasargil MG: Adrenergic innervation of the cerebral blood vessels in the rabbit. J Neurosurg 35:1481541971Peerless SJ Yasargil MG: Adrenergic innervation of the cerebral blood vessels in the rabbit. J Neurosurg 35:148–154 1971

  • 9.

    Ritchie JMCohen PJDripps RD: Cocaine; procaine and other synthetic local anesthetics in Goodman LSGilman A (eds): The Pharmacological Basis of Therapeutics. New YorkMacmillan1965ed 3 pp 367398Ritchie JM Cohen PJ Dripps RD: Cocaine; procaine and other synthetic local anesthetics in Goodman LS Gilman A (eds): The Pharmacological Basis of Therapeutics. New York Macmillan 1965 ed 3 pp 367–398

  • 10.

    Rosenblum WI: Neurogenic control of cerebral circulation. Stroke 2:4294391971Rosenblum WI: Neurogenic control of cerebral circulation. Stroke 2:429–439 1971

  • 11.

    Sato S: An electron microscope study of the innervation of the intracranial artery of the rat. Am J Anat 118:8738891966Sato S: An electron microscope study of the innervation of the intracranial artery of the rat. Am J Anat 118:873–889 1966

  • 12.

    Symon L: Vasospasm in aneurysm in Moossy JJaneway R (eds): Cerebral Vascular Diseases. New YorkGrune & Stratton1971 pp 232240Symon L: Vasospasm in aneurysm in Moossy J Janeway R (eds): Cerebral Vascular Diseases. New York Grune & Stratton 1971 pp 232–240

  • 13.

    Uchida EBohr DF: Myogenic tone in isolated perfused vessels: occurrence among vascular beds and along vascular trees. Circ Res 25:5495551969Uchida E Bohr DF: Myogenic tone in isolated perfused vessels: occurrence among vascular beds and along vascular trees. Circ Res 25:549–555 1969

  • 14.

    Wurtman RJ: Catecholamines. New Engl J Med 273:637646693–700 746–7531965Wurtman RJ: Catecholamines. New Engl J Med 273:637–646 693–700 746–753 1965

TrendMD

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 36 36 6
Full Text Views 154 154 0
PDF Downloads 100 100 0
EPUB Downloads 0 0 0

PubMed

Google Scholar