Lactate accumulation inprimate spinal cord during circulatory arrest

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  • 1 Division of Neurosurgery, College of Medicine, Ohio State University, Columbus, Ohio
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✓ In rhesus monkeys subjected to circulatory arrest, studies were made of the relationship of lactate production in the spinal cord to the duration of circulatory arrest and magnitude of lactate accumulation, and the results were compared to the magnitude of rise in cerebral tissue lactate. Both high and low thoracic laminectomies were performed on each of eight rhesus monkeys. Spinal cord tissue was excised for lactate assay at the upper laminectomy as a control, and a second tissue specimen was excised at the lower laminectomy site at time increments of 30 sec to 30 min after circulatory arrest. Tissue was excised from each site without circulatory arrest in one monkey and showed negligible increase in lactate production, indicating that excision of tissue itself does not result in increased lactate. Nonanoxic samples from seven monkeys averaged 4.60 millimoles (mM)/lactate/kg tissue, with a range of 2.22 to 6.49. Postcirculatory arrest samples from these monkeys averaged 11.10 mM lactate/kg tissue, with a range of 3.62 (at 30 sec) to 14.33 (at 10 min). Anoxic spinal tissue lactate was elevated above controls in each instance, and tissue lactate peaked between 5 to 10 min after circulatory arrest and remained stable with mild fluctuations beyond that time. Thus, the spinal cord responds to circulatory arrest much as cerebral tissue, but with some delay in the accumulation of lactic acid.

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Contributor Notes

Address reprint requests to: David Yashon, M.D., Division of Neurological Surgery, The Ohio State University Hospitals, 410 West Tenth Avenue, Columbus, Ohio 43210.
  • 1.

    Albin MS, , White RJ, & Acosta-Rua G, et al: Study of functional recovery produced by delayed localized cooling after spinal cord injury in primates. J Neurosurg 29:113120, 1968 Albin MS, White RJ, Acosta-Rua G, et al: Study of functional recovery produced by delayed localized cooling after spinal cord injury in primates. J Neurosurg 29:113–120, 1968

    • Search Google Scholar
    • Export Citation
  • 2.

    Bergmeyer HU: Methods of Enzymatic Analysis. New York, Academic Press, 1965, ed 2, pp 254, 266–270 Bergmeyer HU: Methods of Enzymatic Analysis. New York, Academic Press, 1965, ed 2, pp 254, 266–270

    • Search Google Scholar
    • Export Citation
  • 3.

    Danforth WH, , Naegle S, & Bing RJ: Effect of ischemia and reoxygenation on glycolytic reactions and adenosinetriphosphate in heart muscle. Circ Res 8:965971, 1960 Danforth WH, Naegle S, Bing RJ: Effect of ischemia and reoxygenation on glycolytic reactions and adenosinetriphosphate in heart muscle. Circ Res 8:965–971, 1960

    • Search Google Scholar
    • Export Citation
  • 4.

    Feldman RA, , Yashon D, & Locke GE, et al: Ischemia in primate spinal cord injury. (Submitted for publication) Feldman RA, Yashon D, Locke GE, et al: Ischemia in primate spinal cord injury. (Submitted for publication)

    • Search Google Scholar
    • Export Citation
  • 5.

    Gaevskaya MS: Biochemistry of the Brain During the Process of Dying and Resuscitation. New York, Consultants Bureau, 1964, ed 1, pp 3042 Gaevskaya MS: Biochemistry of the Brain During the Process of Dying and Resuscitation. New York, Consultants Bureau, 1964, ed 1, pp 30–42

    • Search Google Scholar
    • Export Citation
  • 6.

    Hurwitz BS, & Wolfson SK Jr: Brain lactate in anoxia and hypothermia: relationship to brain viability. Exp Neurol 23:426434, 1969 Hurwitz BS, Wolfson SK Jr: Brain lactate in anoxia and hypothermia: relationship to brain viability. Exp Neurol 23:426–434, 1969

    • Search Google Scholar
    • Export Citation
  • 7.

    Robinson JS: Hypotension without hypoxia. Int Anesth Clin 5:467480, 1967 Robinson JS: Hypotension without hypoxia. Int Anesth Clin 5:467–480, 1967

    • Search Google Scholar
    • Export Citation
  • 8.

    White A, , Handler P, & Smith HL: Principles of Biochemistry. New York, McGraw-Hill, 1968, ed 4, pp 389421 White A, Handler P, Smith HL: Principles of Biochemistry. New York, McGraw-Hill, 1968, ed 4, pp 389–421

    • Search Google Scholar
    • Export Citation
  • 9.

    Yashon D, , Wagner FC Jr, & Demian YK, et al: Cerebral lactate accumulation and glucose exhaustion during circulatory arrest. Proc Soc Exp Biol Med 133:728730, 1970 Yashon D, Wagner FC Jr, Demian YK, et al: Cerebral lactate accumulation and glucose exhaustion during circulatory arrest. Proc Soc Exp Biol Med 133:728–730, 1970

    • Search Google Scholar
    • Export Citation

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