Ischemia in primate spinal cord injury

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✓ Lactate accumulation in spinal cord tissue following trauma was determined to ascertain the role and magnitude of ischemia. High thoracic and low thoracic laminectomies were performed on each of nine rhesus monkeys. The lower exposed cord was traumatized with a calibrated blow of 300 gm cm. The upper exposed cord served as a nontraumatized control. At time intervals of 1.5 min to 48 hrs after trauma, both cord segments were removed and assayed for lactic acid. Lactate in nontraumatized segments averaged 3.64 mM/kg tissue, with a range of 2.20 to 4.95. Lactate in traumatized segments removed in from 1.5 min to 12 hrs from six monkeys averaged 5.50 mM/kg tissue, with a range of 4.32 to 6.46. Lactate in traumatized segments from three monkeys 18 to 40 hrs after trauma averaged 4.07 mM/kg, with a range of 3.20 to 5.18. This finding supports the concept that ischemia plays a role early in the traumatic process in spinal cord injury.

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Address reprint requests to: David Yashon, M.D., Division of Neurological Surgery, The Ohio State University Hospitals, 410 West Tenth Avenue, Columbus, Ohio 43210.

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    Elevation of spinal cord tissue lactate in early phase following spinal cord trauma.

References

  • 1.

    Albin MSWhite RJAcosta-Rua Get al: Study of functional recovery produced by delayed localized cooling after spinal cord injury in primates. J Neurosurg 29:1131201968Albin MS White RJ Acosta-Rua G et al: Study of functional recovery produced by delayed localized cooling after spinal cord injury in primates. J Neurosurg 29:113–120 1968

  • 2.

    Albin MSWhite RJLocke GEet al: Localized spinal cord hypothermia: anesthetic effects and application to traumatic injury. Anesth Analg 46:8161967Albin MS White RJ Locke GE et al: Localized spinal cord hypothermia: anesthetic effects and application to traumatic injury. Anesth Analg 46:8–16 1967

  • 3.

    Bakay LLee JC: Cerebral Edema. Springfield, IllCharles C Thomas1965Bakay L Lee JC: Cerebral Edema. Springfield Ill Charles C Thomas 1965

  • 4.

    Bergmeyer H: Methods of Enzymatic Analysis. New YorkAcademic Press1965ed 1Bergmeyer H: Methods of Enzymatic Analysis. New York Academic Press 1965 ed 1

  • 5.

    Danforth WigNaegle SBing RJ: Effect of ischemia and reoxygenation on glycolytic reactions and adenosinetriphosphate in heart muscle. Circ Res 8:9659711960Danforth Wig Naegle S Bing RJ: Effect of ischemia and reoxygenation on glycolytic reactions and adenosinetriphosphate in heart muscle. Circ Res 8:965–971 1960

  • 6.

    Feldman RAYashon DLocke GEet al: Lactate accumulation in primate spinal cord during circulatory arrest. (submitted for publication)Feldman RA Yashon D Locke GE et al: Lactate accumulation in primate spinal cord during circulatory arrest. (submitted for publication)

  • 7.

    Hurwitz BSWolfson SK Jr: Brain lactate in anoxia and hypothermia: relationship to brain viability. Exp Neurol 23:4264341969Hurwitz BS Wolfson SK Jr: Brain lactate in anoxia and hypothermia: relationship to brain viability. Exp Neurol 23:426–434 1969

  • 8.

    Lowry OHPassonneau JVHasselberber FXet al: Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J Biol Chem 239:18301964Lowry OH Passonneau JV Hasselberber FX et al: Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J Biol Chem 239:18–30 1964

  • 9.

    Pool JL: Cerebral vasospasm. New Eng J Med 259:125912641958Pool JL: Cerebral vasospasm. New Eng J Med 259:1259–1264 1958

  • 10.

    Robinson JS: Hypotension without hypoxia. Int Anesth Clin 5:4674801967Robinson JS: Hypotension without hypoxia. Int Anesth Clin 5:467–480 1967

  • 11.

    Stone WEMarshall CNims LF: Chemical changes in the brain produced by injury and by anoxia. Amer J Physiol 132:7707751941Stone WE Marshall C Nims LF: Chemical changes in the brain produced by injury and by anoxia. Amer J Physiol 132:770–775 1941

  • 12.

    Wagner FTaslitz NWhite RJet al: Vascular phenomena in the normal and traumatized spinal cord. Anat Rec 163:2811969(abstract)Wagner F Taslitz N White RJ et al: Vascular phenomena in the normal and traumatized spinal cord. Anat Rec 163:281 1969 (abstract)

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