The purpose of this work was to determine what benefits and hazards might be anticipated if flow through an occluded middle cerebral artery could be restored. Possible protective measures of hemodilution were investigated, and particular attention directed to the problem of hemorrhagic cerebral infarction. Information of this nature is of utmost importance in determining the feasibility of middle cerebral artery surgery. The isolated but dramatic reported results serve to stimulate further studies and investigation so that such procedures can be undertaken more often and with reasonable hope of success.3,8
This study is based on experimental procedures in 100 squirrel monkeys and 35 cats. The squirrel monkey was used in the studies of massive cerebral infarction, the cat in those of smaller lesions. The necessity for two models was determined by previous studies and concurrent clinical experience emphasizing the difference between the two sizes of infarction.10,12,14
SundtT. M.Jr.NofzingerJ. D. Clip-grafts for aneurysm and small vessel surgery. Part 1. Repair of segmental defects with clip-grafts; laboratory studies and clinical correlations. Part 2. Clinical application of clip-grafts to aneurysms; technical considerations. J. Neurosurg.196727:477–489.SundtJr.NofzingerJ. Neurosurg.27:477–489.
This work was supported by U.S. Public Health Service Grants NB-06822 and NB-06826.