Experimental Cerebral Infarction: Modification by Treatment with Hemodiluting, Hemoconcentrating, and Dehydrating Agents

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Special National Institutes of Health Fellow in Basic Neurologic Sciences, Mayo Graduate School of Medicine, University of Minnesota, Rochester, Minn.

© AANS, except where prohibited by US copyright law.

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Figures

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    Superficial microvasculature of the brains of cats after occlusion of the ipsilateral middle cerebral artery. Left. This animal had been given concentrated serum albumin intravenously. At 7 days postoperatively, the infarct resulting from the occlusion did not extend to the cortical area shown in the photograph. Note the markedly increased vascularity of the cortex and the tortuosity of the small vessels. (Magnification, × 16.) Right. This animal had been given packed erythrocytes intravenously. At 5 days postoperatively there was reduction in number of visible vessels in the area of infarcted cortex; regions of stasis in venous channels were seen. (Magnification, × 12).

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    Sections of the brain of a cat killed 6 days after occlusion of the left middle cerebral artery. This animal had no treatment. The infarct is located laterally and superficially.

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    Sections of the brain of a cat killed 6 days after occlusion of the left middle cerebral artery. No. treatment had been given. The infarct is deep, near the basal ganglia.

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    Distribution of volumes of infarcts in the untreated (control) and treated groups of cats. Open bars represent cats killed 5 to 7 days postoperatively; hatched bars represent animals dying before 72 hours postoperatively.

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    Sections of the brain of a cat killed 7 days after occlusion of the left middle cerebral artery. This animal had been treated with a combination of serum albumin, low-molecular-weight dextran, and urea. No infarct was found.

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    Sections of the brain of a cat that died 18 hours after occlusion of the left middle cerebral artery. This animal had been given physiologic saline intravenously. There is a considerable amount of cerebral edema, with a shift of midline structures to the side opposite the occlusion.

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