Scanning with Positron-Emitting Radioisotopes: Aneurysm, Arteriovenous Malformation and Intracerebral Hemorrhage

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Positron-emitting isotopes arsenic-74 and copper-64 are used to perform radioisotopic brain scans at the Massachusetts General Hospital. From 1958 to 1963 a total of 61 scans was done on 55 patients with confirmed diagnoses of aneurysm, arteriovenous malformation, and subarachnoid or intracerebral hemorrhage (Table 1). In this report the appearance of the scan, the degree of neurologic deficit, the interval of time from onset of symptoms to scan, and the angiographic and pathologic findings are correlated. In a companion paper,23 the findings were reported in 146 cases of occlusive cerebral vascular disease studied similarly.

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Figures

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    Case 1. (Left) Positrocephalogram. Aneurysm of anterior communicating artery showing increased concentration in frontal and anterior parietal areas damaged by infarction. (Right) Asymmetrogammagram. The curved marks indicate right-sided concentration.

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    Positrocephalogram in a case of arteriovenous malformation in the inferior frontal-parietal area.

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    Concentration of As74 and Cu64 in an intracerebral hematoma; surrounding tissue and blood (semilogarithmic plot).

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    (Left) Lateral positrocephalogram indicating frontal-temporal abnormality in an intracerebral hemorrhage 5 days after onset. The concentration of isotope in samples of tissue from this case is recorded in Fig. 3. (Right) Anteroposterior positrocephalogram in the same patient.

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