Suppression of Epileptic Movements in the Presence of Grand Mal Seizure Discharges

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    Ultrasonic suppression of epileptic movement in Cat 10. (A) Following ultrasonic irradiation at 6 watts per cm.2 for 45 sec. motor signs of the seizure discharge disappear. This record was taken 70 min. after record depicted in B of Fig. 1. (B) Electroencephalogram 3 weeks following ultrasonic irradiation. Seizures never returned and the animal's behavior appeared normal.

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    Focal slow spiking with subsequent spread to self-sustaining seizure discharge in Cat 10. (A) Localized slow spikes arising spontaneously from right posterior cortex 8 min. following injection of .05 cc. crystalline penicillin. Concomitant motor activity in left ear is recorded on channel 7. (B) Grand mal seizure discharge with generalized involvement 50 min. after injection of penicillin.

    The following abbreviations are used in this and subsequent figures: L Ant = left anterior cortex (posterior cruciate gyrus); R Ant = right anterior cortex; L Post = left posterior cortex (posterior ectosylvian gyrus); R Post = right posterior cortex; EKG = cardiac rate; RESP = respiration; L EAR — G = movement of left ear; L STM and R STM = electromyogram of left and right semitendinosus muscle.

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    Electroencephalogram monitored concomitantly with ultrasonic irradiation (Cat 2).

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    Weil-stained section through brain of Cat 6. The lesion produced by penicillin can be seen in the upper left of the section as can the destruction produced by ultrasound, limited principally to white matter, and “sectioning” the projection fibers from the epileptogenic foci.

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    Electroencephalogram taken 2 hours postirradiation (Cat 3), showing peculiar patterns resulting from high-intensity irradiation.

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