Complications Following Injection of Sclerosing Agent to Precipitate Fibro-Osseous Proliferation

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A Monograph was published in 19562 purporting to show that chronic low backache is in many instances the result of relaxation of the ligaments about the joints of the spine and pelvis. Treatment by the injection of an irritating solution consisting of the sodium salt of a vegetableoil fatty acid, similar to that employed in the injection and treatment of varicose veins, was recommended. This treatment is alleged to produce proliferation of fibrous tissue and bone, thereby stabilizing the involved joints. Four thousand injections were reported, with “no unfavorable incident or sequelae.” Complete relief of symptoms was

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    Case 2 (A) View of anterior portion of spinal cord showing adherent and thickened meninges, demyelinization, and degeneration of anterior horns.

    (B) Higher magnification of segment from A. Two stages of degeneration are represented. The one on the right shows demyelinization, gliosis, and degeneration of fiber pathways. The one on the left shows a more recent episode with numerous gitter cells.

    (C) Thickening of leptomeninges and dura mater with degeneration of anterior nerve roots.

    (D) Leptomeningeal artery with peri- and endarteritis. The lumen of the vessel is reduced.

References

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BeharA. J. and FeldmanS. Pathogenesis of adhesive arachnoiditis. An experimental study. J. Neuropath exp. Neurol.195716: 261268.Behar A. J. and Feldman S. Pathogenesis of adhesive arachnoiditis. An experimental study. J. Neuropath exp. Neurol. 1957 16: 261–268.

2.

HackettG. S. Joint ligament relaxation treated by fibro-osseous proliferation. With special reference to low back disability—trigger point pain referred pain and sciatica-tendon relaxation. Springfield, Ill.: Charles C Thomas19572nd ed.xv115 pp.Hackett G. S. Joint ligament relaxation treated by fibro-osseous proliferation. With special reference to low back disability—trigger point pain referred pain and sciatica-tendon relaxation. Springfield Ill.: Charles C Thomas 1957 2nd ed. xv 115 pp.

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HurstE. W. Adhesive arachnoiditis and vascular blockage caused by detergents and other chemical irritants: an experimental study. J. Path. Bact.195570: 167178.Hurst E. W. Adhesive arachnoiditis and vascular blockage caused by detergents and other chemical irritants: an experimental study. J. Path. Bact. 1955 70: 167–178.

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KeplingerJ. E. and BucyP. C. Paraplegia from treatment with sclerosing agents. Report of a case. J. Amer. med. Ass.1960173: 13831335.Keplinger J. E. and Bucy P. C. Paraplegia from treatment with sclerosing agents. Report of a case. J. Amer. med. Ass. 1960 173: 1383–1335.

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McLaurinR. L.BaileyO. T.SchurrP. H. and IngrahamF. D. Myelomalacia and multiple cavitations of spinal cord secondary to adhesive arachnoiditis. An experimental study. Arch. Path.195457: 138146.McLaurin R. L. Bailey O. T. Schurr P. H. and Ingraham F. D. Myelomalacia and multiple cavitations of spinal cord secondary to adhesive arachnoiditis. An experimental study. Arch. Path. 1954 57: 138–146.

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SchneiderR. C.WilliamsJ. J. and LissL. Fatility after injection of sclerosing agent to precipitate fibro-osseous proliferation. J. Amer. med. Ass.1959170: 17681772.Schneider R. C. Williams J. J. and Liss L. Fatility after injection of sclerosing agent to precipitate fibro-osseous proliferation. J. Amer. med. Ass. 1959 170: 1768–1772.

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