Intraarterial encephalography from an acutely implanted aneurysm embolization device in awake humans

Luyuan LiDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa;

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Kenji IbayashiDepartment of Neurosurgery, Jichi Medical University, Tochigi, Japan; and

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Anthony PiscopoDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa;

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Carolina Deifelt StreeseDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa;

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Haiming ChenDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa;

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Jeremy D. W. GreenleeDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa;

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David M. HasanDepartment of Neurosurgery, Duke University, Durham, North Carolina

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Publication Date:
05 Aug 2022
Page Range:
785–792
Volume/Issue:
Volume 138: Issue 3
DOI link:
https://doi.org/10.3171/2022.6.JNS22932
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OBJECTIVE

Endovascular electroencephalography (evEEG) uses the cerebrovascular system to record electrical activity from adjacent neural structures. The safety, feasibility, and efficacy of using the Woven EndoBridge Aneurysm Embolization System (WEB) for evEEG has not been investigated.

METHODS

Seventeen participants undergoing awake WEB endovascular treatment of unruptured cerebral aneurysms were included. After WEB deployment and before detachment, its distal deployment wire was connected to an EEG receiver, and participants performed a decision-making task for 10 minutes. WEB and scalp recordings were captured.

RESULTS

All patients underwent successful embolization and evEEG with no complications. Event-related potentials were detected on scalp EEG in 9/17 (53%) patients. Of these 9 patients, a task-related low-gamma (30–70 Hz) response on WEB channels was captured in 8/9 (89%) cases. In these 8 patients, the WEB was deployed in 2 middle cerebral arteries, 3 anterior communicating arteries, the terminal internal carotid artery, and 2 basilar tip aneurysms. Electrocardiogram artifact on WEB channels was present in 12/17 cases.

CONCLUSIONS

The WEB implanted within cerebral aneurysms of awake patients is capable of capturing task-specific brain electrical activities. Future studies are warranted to establish the efficacy of and support for evEEG as a tool for brain recording, brain stimulation, and brain-machine interface applications.

ABBREVIATIONS

ACOM = anterior communicating artery; AEP = averaged evoked potential; DBT = demodulated band transformation; EEG = electroencephalography; EKG = electrocardiogram; ERBP = event-related band power; evEEG = endovascular EEG; ICA = internal carotid artery; MCA = middle cerebral artery; WEB = Woven EndoBridge Aneurysm Embolization System.
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Cover Journal of Neurosurgery

Volume 138: Issue 3 (Mar 2023)

in Journal of Neurosurgery

Figure from Alzahrani et al. (pp 858–867). Illustrations (left) © Rajiv Midha, published with permission.

Contributor Notes

Correspondence David M. Hasan: Duke University, Durham, NC. david.hasan@duke.edu.

INCLUDE WHEN CITING Published online August 5, 2022; DOI: 10.3171/2022.6.JNS22932.

Disclosures Funding for this study consisted of an education research grant from MicroVention as well as a research fellowship grant from the Neurosurgery Research & Education Foundation.

  • 1

    Mukamel R, Fried I. Human intracranial recordings and cognitive neuroscience. Annu Rev Psychol. 2012;63:511–537.

  • 2

    Yan H, Katz JS, Anderson M, et al. Method of invasive monitoring in epilepsy surgery and seizure freedom and morbidity: a systematic review. Epilepsia. 2019;60(9):1960–1972.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3

    Gooneratne IK, Mannan S, de Tisi J, et al. Somatic complications of epilepsy surgery over 25 years at a single center. Epilepsy Res. 2017;132:70–77.

    • Search Google Scholar
    • Export Citation
  • 4

    Hamer HM, Morris HH, Mascha EJ, et al. Complications of invasive video-EEG monitoring with subdural grid electrodes. Neurology. 2002;58(1):97–103.

  • 5

    Sefcik RK, Opie NL, John SE, Kellner CP, Mocco J, Oxley TJ. The evolution of endovascular electroencephalography: historical perspective and future applications. Neurosurg Focus. 2016;40(5):E7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6

    Penn RD, Hilal SK, Michelsen WJ, Goldensohn ES, Driller J. Intravascular intracranial EEG recording. Technical note. J Neurosurg. 1973;38(2):239–243.

  • 7

    Reuter BM, Brassel F, Linke DB, Hartmann A, Kurthen M. Depth EEG and evoked potentials using an intravascular catheter electrode in the baboon. Article in German. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1989;20(2):81–83.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8

    Nakase H, Ohnishi H, Touho H, Karasawa J, Yamamoto S, Shimizu K. An intra-arterial electrode for intracranial electro-encephalogram recordings. Acta Neurochir (Wien). 1995;136(1-2):103–105.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Stoeter P, Dieterle L, Meyer A, Prey N. Intracranial electroencephalographic and evoked-potential recording from intravascular guide wires. AJNR Am J Neuroradiol. 1995;16(6):1214–1217.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Mikuni N, Ikeda A, Murao K, et al. "Cavernous sinus EEG": a new method for the preoperative evaluation of temporal lobe epilepsy. Epilepsia. 1997;38(4):472–482.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    García-Asensio S, Guelbenzu S, Barrena R, Valero P. Technical aspects of intra-arterial electroencephalogram recording. Interv Neuroradiol. 1999;5(4):289–300.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Watanabe H, Takahashi H, Nakao M, Walton K, Llinás RR. Intravascular neural interface with nanowire electrode. Electron Commun Jpn. 2009;92(7):29–37.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Oxley TJ, Opie NL, John SE, et al. Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity. Nat Biotechnol. 2016;34(3):320–327.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14

    Bower MR, Stead M, Van Gompel JJ, et al. Intravenous recording of intracranial, broadband EEG. J Neurosci Methods. 2013;214(1):21–26.

  • 15

    Soldozy S, Young S, Kumar JS, et al. A systematic review of endovascular stent-electrode arrays, a minimally invasive approach to brain-machine interfaces. Neurosurg Focus. 2020;49(1):E3.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Wong YT, Opie NL, John SE, et al. Suitability of nitinol electrodes in neural prostheses such as endovascular neural interfaces. Annu Int Conf IEEE Eng Med Biol Soc. 2016;2016:4463–4466.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17

    Ishii D, Li L, Zanaty M, et al. Safety and feasibility of the Woven EndoBridge device deployment with monitored anesthesia care. Interv Neuroradiol. 2020;26(6):767–771.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    FitzGerald TH, Seymour B, Dolan RJ. The role of human orbitofrontal cortex in value comparison for incommensurable objects. J Neurosci. 2009;29(26):8388–8395.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19

    Kovach CK, Gander PE. The demodulated band transform. J Neurosci Methods. 2016;261:135–154.

  • 20

    Forsyth IA, Dunston M, Lombardi G, et al. Evaluation of a minimally invasive endovascular neural interface for decoding motor activity. In: Maharbiz M, Chestek C, eds.9th International IEEE EMBS Conference on Neural Engineering. IEEE; 2019;750–753.

    • Search Google Scholar
    • Export Citation
  • 21

    John SE, Apollo NV, Opie NL, et al. In vivo impedance characterization of cortical recording electrodes shows dependence on electrode location and size. IEEE Trans Biomed Eng. 2019;66(3):675–681.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22

    John SE, Opie NL, Wong YT, et al. Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable. Sci Rep. 2018;8(1):8427.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23

    Oxley TJ, Yoo PE, Rind GS, et al. Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience. J Neurointerv Surg. 2021;13(2):102–108.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24

    Cogan SF. Neural stimulation and recording electrodes. Annu Rev Biomed Eng. 2008;10:275–309.

  • 25

    Hiser J, Koenigs M. The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology. Biol Psychiatry. 2018;83(8):638–647.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26

    Wen HT, Rhoton AL Jr, de Oliveira E, et al. Microsurgical anatomy of the temporal lobe: part 1: mesial temporal lobe anatomy and its vascular relationships as applied to amygdalohippocampectomy. Neurosurgery. 1999;45(3):549–592.

    • PubMed
    • Search Google Scholar
    • Export Citation

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