Comparison of supratentorial meningioma resection outcomes by dural reconstruction technique

Silky ChotaiDepartment of Neurological Surgery, Vanderbilt University Medical Center;

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Alan R. TangVanderbilt University School of Medicine; and

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Jake R. McDermottVanderbilt University, Nashville, Tennessee

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Bradley S. GuidryVanderbilt University School of Medicine; and

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Candace J. GrishamVanderbilt University School of Medicine; and

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Aaron M. Yengo-KahnDepartment of Neurological Surgery, Vanderbilt University Medical Center;

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Peter J. MoroneDepartment of Neurological Surgery, Vanderbilt University Medical Center;

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Reid C. ThompsonDepartment of Neurological Surgery, Vanderbilt University Medical Center;

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Lola B. ChamblessDepartment of Neurological Surgery, Vanderbilt University Medical Center;

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OBJECTIVE

Excision of intracranial meningiomas often requires resection or coagulation of the dura mater. The choice of dural closure technique is individualized and based on surgeon preference. The objective of this study was to determine outcomes following various dural closure techniques for supratentorial meningiomas.

METHODS

A retrospective, single-center cohort study was performed for patients who underwent excision of supratentorial meningiomas from 2000 to 2019. Outcomes including operative time, postoperative in-hospital complications, readmission, causes of readmission including surgical site infection, pseudomeningocele, need for shunt surgery, and imaging appearance of pseudomeningocele on long-term follow-up imaging were compared. Univariate and multivariable analyses were conducted.

RESULTS

A total of 353 patients who had complete clinical and operative data available for review were included. Of these patients, 227 (64.3%) had nonsutured dural graft reconstruction and 126 (35.7%) had sutured dural repair, including primary closure, artificial dura, or pericranial graft. There was significant variability in using nonsutured dural reconstruction compared with sutured dural repair technique among surgeons (p < 0.001). Tumors with sagittal sinus involvement were more likely to undergo nonsutured closure (n = 79, 34.8%) than dural repair (n = 26, 20.6%) (p = 0.003). There were no other differences in preoperative imaging findings or WHO grade. Frequency of surgical site infection and pseudomeningocele, need for shunt surgery, and recurrence were similar between those undergoing nonsutured and those undergoing sutured dural repair. The mean operative time for the study cohort was 234.9 (SD 106.6) minutes. The nonsutured dural reconstruction group had a significantly shorter mean operative time (223.9 [SD 99.7] minutes) than the sutured dural repair group (254.5 [SD 115.8] minutes) (p = 0.015). In a multivariable linear regression analysis, after controlling for tumor size and sinus involvement, nonsutured dural graft reconstruction was associated with a 36.8-minute reduction (95% CI −60.3 to −13.2 minutes; p = 0.002) in operative time.

CONCLUSIONS

Dural reconstruction using a nonsutured graft and sutured dural repair exhibit similar postoperative outcomes for patients undergoing resection for supratentorial meningiomas. Although sutured grafts may sometimes be necessary, nonsutured graft reconstruction for most supratentorial meningioma resections may suffice. The decreased operative time associated with nonsutured grafts may ultimately result in cost savings. These findings should be taken into consideration when selecting a dural reconstruction technique for supratentorial meningioma.

ABBREVIATIONS

GTR = gross-total resection.
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Figure from Ramos et al. (pp 95–103).

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