Editorial. What causes excitotoxicity after concussion?

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  • 1 Neurosurgery and
  • | 2 Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico
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  • 1

    Masse I, Moquin L, Bouchard C, Gratton A, De Beaumont L. Efficacy of prophylactic versus therapeutic administration of the NMDA receptor antagonist MK-801 on the acute neurochemical response to a concussion in a rat model combining force and rotation. J Neurosurg. Published online October 15, 2021.doi: 10.3171/2021.3.JNS204163

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  • 2

    Bouley J, Chung DY, Ayata C, Brown RH Jr, Henninger N. Cortical spreading depression denotes concussion injury. J Neurotrauma. 2019;36(7):10081017.

  • 3

    Pacheco JM, Hines-Lanham A, Stratton C, et al. Spreading depolarizations occur in mild traumatic brain injuries and are associated with postinjury behavior. eNeuro. 2019;6(6).

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4

    Muir KW, Lees KR. Excitatory amino acid antagonists for acute stroke. Cochrane Database Syst Rev. 2003;(3):CD001244.

  • 5

    Willis C, Lybrand S, Bellamy N. Excitatory amino acid inhibitors for traumatic brain injury. Cochrane Database Syst Rev. 2004;(1): CD003986.

  • 6

    Hinzman JM, DiNapoli VA, Mahoney EJ, Gerhardt GA, Hartings JA. Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions. Exp Neurol. 2015;267:243253.

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    • PubMed
    • Search Google Scholar
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  • 7

    Aiba I, Shuttleworth CW. Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons. J Physiol. 2012;590(22):58775893.

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    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8

    Hartings JA, Shuttleworth CW, Kirov SA, et al. The continuum of spreading depolarizations in acute cortical lesion development: examining Leao’s legacy. J Cereb Blood Flow Metab. 2017;37(5):15711594.

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    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Hartings JA, Strong AJ, Fabricius M, et al. Spreading depolarizations and late secondary insults after traumatic brain injury. J Neurotrauma. 2009;26(11):18571866.

  • 10

    Ayata C. Spreading depression: from serendipity to targeted therapy in migraine prophylaxis. Cephalalgia. 2009;29(10):10951114.

  • 11

    Carlson AP, Abbas M, Alunday RL, Qeadan F, Shuttleworth CW. Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial. J Neurosurg. 2019;130(5):15131519.

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    • Search Google Scholar
    • Export Citation
  • 12

    Peeters M, Gunthorpe MJ, Strijbos PJ, Goldsmith P, Upton N, James MF. Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine. J Pharmacol Exp Ther. 2007;321(2):564572.

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    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Carlson AP, Alchbli A, Hanggi D, Macdonald RL, Shuttleworth CW. Effect of locally delivered nimodipine microparticles on spreading depolarization in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2021;24:345349.

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    • Search Google Scholar
    • Export Citation
  • 1

    Giza CC, Hovda DA. The new neurometabolic cascade of concussion. Neurosurgery. 2014;75(suppl 4):S24S33.

  • 2

    Chamoun R, Suki D, Gopinath SP, Goodman JC, Robertson C. Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury. J Neurosurg. 2010;113(3):564570.

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    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3

    Purins K, Lewen A, Hillered L, Howells T, Enblad P. Brain tissue oxygenation and cerebral metabolic patterns in focal and diffuse traumatic brain injury. Front Neurol. 2014;5:64.

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    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4

    Bouley J, Chung DY, Ayata C, Brown RH Jr, Henninger N. Cortical spreading depression denotes concussion injury. J Neurotrauma. 2019;36(7):10081017.

  • 5

    Pacheco JM, Hines-Lanham A, Stratton C, et al. Spreading depolarizations occur in mild traumatic brain injuries and are associated with postinjury behavior. eNeuro. 2019;6(6).

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation

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