Petroclival meningiomas: long-term outcomes of multimodal treatments and management strategies based on 30 years of experience at a single institution

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  • 1 Department of Neurosurgery, Seoul National University Hospital; and
  • 2 Department of Neurosurgery, Seoul Metropolitan Government–Seoul National University Boramae Medical Center, Seoul, Korea
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OBJECTIVE

A thorough investigation of the long-term outcomes and chronological changes of multimodal treatments for petroclival meningiomas is required to establish optimal management strategies. The authors retrospectively reviewed the long-term clinical outcomes of patients with petroclival meningioma according to various treatments, including various surgical approaches, and they suggest treatment strategies based on 30 years of experience at a single institution.

METHODS

Ninety-two patients with petroclival meningiomas were treated surgically at the authors’ institution from 1986 to 2015. Patient demographics, overall survival, local tumor control rates, and functional outcomes according to multimodal treatments, as well as chronological change in management strategies, were evaluated. The mean clinical and radiological follow-up periods were 121 months (range 1–368 months) and 105 months (range 1–348 months), respectively.

RESULTS

A posterior transpetrosal approach was most frequently selected and was followed in 44 patients (48%); a simple retrosigmoid approach, undertaken in 30 patients, was the second most common. The initial extent of resection and following adjuvant treatment modality were classified into 3 subgroups: gross-total resection (GTR) only in 13 patients; non-GTR treatment followed by adjuvant radiosurgery or radiation therapy (non-GTR+RS/RT) in 56 patients; and non-GTR without adjuvant treatment (non-GTR only) in 23 patients. The overall progression-free survival rate was 85.8% at 5 years and 81.2% at 10 years. Progression or recurrence rates according to each subgroup were 7.7%, 12.5%, and 30.4%, respectively.

CONCLUSIONS

The authors’ preferred multimodal treatment strategy, that of planned incomplete resection and subsequent adjuvant radiosurgery, is a feasible option for the management of patients with large petroclival meningiomas, considering both local tumor control and postoperative quality of life.

ABBREVIATIONS CN = cranial nerve; GKRS = Gamma Knife radiosurgery; GTR = gross-total resection; KPS = Karnofsky Performance Scale; PR = partial resection; RS = radiosurgery; RT = radiation therapy; SRS = stereotactic radiosurgery; STR = subtotal resection; WHO = World Health Organization.

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Contributor Notes

Correspondence Sang Hyung Lee: SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea. nslee@snu.ac.kr.

INCLUDE WHEN CITING Published online May 10, 2019; DOI: 10.3171/2019.2.JNS182604.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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