Screening duplex ultrasonography in neurosurgery patients does not correlate with a reduction in pulmonary embolism rate or decreased mortality

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  • 1 University of Mississippi School of Medicine, Jackson, Mississippi;
  • | 2 Department of Medicine, Stanford University, Stanford, California;
  • | 3 Department of Neurological Surgery, Vanderbilt University, Nashville, Tennessee;
  • | 4 Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; and
  • | 5 Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi
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Deep vein thrombosis (DVT) is a major focus of patient safety indicators and a common cause of morbidity and mortality. Many practices have employed lower-extremity screening ultrasonography in addition to chemoprophylaxis and the use of sequential compression devices in an effort to reduce poor outcomes. However, the role of screening in directly decreasing pulmonary emboli (PEs) and mortality is unclear. At the University of Mississippi Medical Center, a policy change provided the opportunity to compare independent groups: patients treated under a prior paradigm of weekly screening ultrasonography versus a post–policy change group in which weekly surveillance was no longer performed.


A total of 2532 consecutive cases were reviewed, with a 4-month washout period around the time of the policy change. Criteria for inclusion were admission to the neurosurgical service or consultation for ≥ 72 hours and hospitalization for ≥ 72 hours. Patients with a known diagnosis of DVT on admission or previous inferior vena cava (IVC) filter placement were excluded. The primary outcome examined was the rate of PE diagnosis, with secondary outcomes of all-cause mortality at discharge, DVT diagnosis rate, and IVC filter placement rate. A p value < 0.05 was considered significant.


A total of 485 patients met the criteria for the pre–policy change group and 504 for the post–policy change group. Data are presented as screening (pre–policy change) versus no screening (post–policy change). There was no difference in the PE rate (2% in both groups, p = 0.72) or all-cause mortality at discharge (7% vs 6%, p = 0.49). There were significant differences in the lower-extremity DVT rate (10% vs 3%, p < 0.01) or IVC filter rate (6% vs 2%, p < 0.01).


Based on these data, screening Doppler ultrasound examinations, in conjunction with standard-of-practice techniques to prevent thromboembolism, do not appear to confer a benefit to patients. While the screening group had significantly higher rates of DVT diagnosis and IVC filter placement, the screening, additional diagnoses, and subsequent interventions did not appear to improve patient outcomes. Ultimately, this makes DVT screening difficult to justify.


BMI = body mass index; DVT = deep vein thrombosis; EVD = external ventricular drain; ICU = intensive care unit; IVC = inferior vena cava; LEDUS = lower-extremity Doppler ultrasonography; LOS = length of stay; PE = pulmonary embolus; UMMC = University of Mississippi Medical Center; VTE = venous thromboembolism.

Supplementary Materials

    • Supplementary Tables 1 and 2 (PDF 421 KB)

Illustration from Ivan et al. (pp 1517–1528). Copyright Kenneth Probst. Published with permission.

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