The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea

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  • 1 Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee; and
  • 2 Departments of Neurology and
  • 3 Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois

OBJECTIVE

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death for patients with refractory epilepsy, and there is increasing evidence for a centrally mediated respiratory depression as a pathophysiological mechanism. The brain regions responsible for a seizure’s inducing respiratory depression are unclear—the respiratory nuclei in the brainstem are thought to be involved, but involvement of forebrain structures is not yet understood. The aim of this study was to analyze intracranial EEGs in combination with the results of respiratory monitoring to investigate the relationship between seizure spread to specific mesial temporal brain regions and the onset of respiratory dysfunction and apnea.

METHODS

The authors reviewed all invasive electroencephalographic studies performed at Northwestern Memorial Hospital (Chicago) since 2010 to identify those cases in which 1) multiple mesial temporal electrodes (amygdala and hippocampal) were placed, 2) seizures were captured, and 3) patients’ respiration was monitored. They identified 8 investigations meeting these criteria in patients with temporal lobe epilepsy, and these investigations yielded data on a total of 22 seizures for analysis.

RESULTS

The onset of ictal apnea associated with each seizure was highly correlated with seizure spread to the amygdala. Onset of apnea occurred 2.7 ± 0.4 (mean ± SEM) seconds after the spread of the seizure to the amygdala, which was significantly earlier than after spread to the hippocampus (10.2 ± 0.7 seconds; p < 0.01).

CONCLUSIONS

The findings suggest that activation of amygdalar networks is correlated with central apnea during seizures. This study builds on the authors’ prior work that demonstrates a role for the amygdala in voluntary respiratory control and suggests a further role in dysfunctional breathing states seen during seizures, with implications for SUDEP pathophysiology.

ABBREVIATIONS EEG = electroencephalography; EMU = epilepsy monitoring unit; FSL = FMRIB Software Library; MNI = Montreal Neurological Institute; NMH = Northwestern Memorial Hospital; SUDEP = sudden unexpected death in epilepsy; TLE = temporal lobe epilepsy.

Supplementary Materials

    • Supplementary Figs 1 and 2 (PDF 1.47 MB)

Contributor Notes

Correspondence William P. Nobis: Vanderbilt University Medical Center, Nashville, TN. william.p.nobis@vumc.org.

INCLUDE WHEN CITING Published online April 5, 2019; DOI: 10.3171/2019.1.JNS183157.

C.Z. and S.S. share senior authorship of this work.

Disclosures Dr. Gerard reports being a speaker for UCB-China and receiving study-related clinical or research support from SAGE and Sunovion.

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