Absence of bacteria in intracranial aneurysms

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  • 1 Department of Neurosurgery, Lille University Hospital, Hopital Nord;
  • | 2 University Lille, INSERM, CHU Lille, U1189-ONCO-THAI-Image Assisted Laser Therapy for Oncology, Lille;
  • | 3 Laboratory of Bacteriology, Lille University Hospital, Hopital Nord;
  • | 4 Department of Neuroradiology, Lille University Hospital, Hopital Nord, France; and
  • | 5 Department of Neurosurgery, Antwerp University Hospital, University of Antwerp, Belgium
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OBJECTIVE

This study aimed to detect the presence of bacteria in the walls of both unruptured and ruptured aneurysms in a French population.

METHODS

Patients treated between January 2018 and July 2018 were included in a prospective study when specimens from ruptured or unruptured aneurysm walls were obtained intraoperatively. Samples from superficial temporal artery, dura mater, and middle meningeal artery were obtained from each patient during the same surgical procedure to be used as a negative control. Direct bacterial analysis, aerobic and anaerobic bacterial culture, and bacterial DNA detection were performed on each sample.

RESULTS

There were 21 women and 9 men with a mean age at treatment of 54 years (range 31–70 years). Eighteen patients were smokers. Hypertension was present in 18 patients and hyperlipidemia in 5 patients. Chronic alcoholism was found in 6 patients. Polycystic kidney disease was present in 1 patient. Fifteen patients had multiple intracranial aneurysms. Ten patients had a ruptured aneurysm and 20 had an unruptured aneurysm. The mean diameter of all aneurysms was 8.5 mm (range 2.5–50 mm). No presence of bacteria was detected with direct bacterial analysis and culture in any of the samples. No bacterial DNA was detected in any of the samples.

CONCLUSIONS

Unlike in Finnish patients, no bacterial presence was found in the wall of aneurysms in French patients. This absence of bacterial infection might explain the lower risk of aneurysm rupture in the French population compared to the Finnish population.

ABBREVIATIONS

ACoA = anterior communicating artery; MCA = middle cerebral artery; MMA = middle meningeal artery; mRS = modified Rankin Scale; PCoA = posterior communicating artery; PCR = polymerase chain reaction; rRNA = ribosomal RNA; STA = superficial temporal artery; WFNS = World Federation of Neurosurgical Societies.

Illustration from Duan et al. (pp 1174–1181).

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Contributor Notes

Correspondence Rabih Aboukais: Lille University Hospital, Lille, France. rabihdoc@hotmail.com.

INCLUDE WHEN CITING Published online March 1, 2019; DOI: 10.3171/2018.12.JNS183044.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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