Dystonic tics induced by deep brain stimulation of the posterior subthalamic area for essential tremor

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OBJECTIVE

The posterior subthalamic area (PSA) is a promising target of deep brain stimulation (DBS) for medication-refractory essential tremor (ET). This case series describes a novel adverse effect manifesting as dystonic tics in patients with ET undergoing DBS of the PSA.

METHODS

Six patients with ET received electrode implants for DBS of the dorsal and caudal zona incerta subregions of the PSA.

RESULTS

Five of the 6 patients developed dystonic tics soon after clinical programming. These tics were of varying severity and required reduction of the electrical stimulation amplitude. This reduction resolved tic occurrence without significantly affecting ET control. Dystonic tics were not observed in 39 additional patients who underwent DBS of the same brain regions for controlling non-ET movement disorders.

CONCLUSIONS

The pathophysiology of tic disorders is poorly understood and may involve the basal ganglia and related cortico-striato-thalamo-cortical circuits. This series is the first report of DBS-induced tics after stimulation of any brain target. Although the PSA has not previously been implicated in tic pathophysiology, it may be a candidate region for future studies.

ABBREVIATIONScZI = caudal zona incerta; DBS = deep brain stimulation; DSM-5 = Diagnostic and Statistical Manual of Mental Disorders, 5th Edition; dZI = dorsal zona incerta; ET = essential tremor; PSA = posterior subthalamic area.
Article Information

Contributor Notes

INCLUDE WHEN CITING Published online April 29, 2016; DOI: 10.3171/2015.12.JNS15915.Correspondence Christopher Lind, Neurosurgical Service of Western Australia, First Fl., G Block, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia. email: christopher.lind@health.wa.gov.au.

© AANS, except where prohibited by US copyright law.

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