A probabilistic map of the human ventral sensorimotor cortex using electrical stimulation

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OBJECT

The human ventral sensorimotor cortex (vSMC) is involved in facial expression, mastication, and swallowing, as well as the dynamic and highly coordinated movements of human speech production. However, vSMC organization remains poorly understood, and previously published population-driven maps of its somatotopy do not accurately reflect the variability across individuals in a quantitative, probabilistic fashion. The goal of this study was to describe the responses to electrical stimulation of the vSMC, generate probabilistic maps of function in the vSMC, and quantify the variability across individuals.

METHODS

Photographic, video, and stereotactic MRI data of intraoperative electrical stimulation of the vSMC were collected for 33 patients undergoing awake craniotomy. Stimulation sites were converted to a 2D coordinate system based on anatomical landmarks. Motor, sensory, and speech stimulation responses were reviewed and classified. Probabilistic maps of stimulation responses were generated, and spatial variance was quantified.

RESULTS

In 33 patients, the authors identified 194 motor, 212 sensory, 61 speech-arrest, and 27 mixed responses. Responses were complex, stereotyped, and mostly nonphysiological movements, involving hand, orofacial, and laryngeal musculature. Within individuals, the presence of oral movement representations varied; however, the dorsal-ventral order was always preserved. The most robust motor responses were jaw (probability 0.85), tongue (0.64), lips (0.58), and throat (0.52). Vocalizations were seen in 6 patients (0.18), more dorsally near lip and dorsal throat areas. Sensory responses were spatially dispersed; however, patients' subjective reports were highly precise in localization within the mouth. The most robust responses included tongue (0.82) and lips (0.42). The probability of speech arrest was 0.85, highest 15–20 mm anterior to the central sulcus and just dorsal to the sylvian fissure, in the anterior precentral gyrus or pars opercularis.

CONCLUSIONS

The authors report probabilistic maps of function in the human vSMC based on intraoperative cortical electrical stimulation. These results define the expected range of mapping outcomes in the vSMC of a single individual and shed light on the functional organization of the vSMC supporting speech motor control and nonspeech functions.

ABBREVIATIONSAIC = Akaike information criterion; AP = anterior-posterior; CN = cranial nerve; CS = central sulcus; dSMC = dorsal SMC; DV = dorsal-ventral; ECoG = electrocorticography; ECS = electrocortical stimulation; fMRI = functional MRI; MNI = Montreal Neurological Institute; SF = sylvian fissure; SMC = sensorimotor cortex; vSMC = ventral SMC.
Article Information

Contributor Notes

Correspondence Edward F. Chang, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave., M-779, San Francisco, CA 94143-0112. email: changed@neurosurg.ucsf.edu.INCLUDE WHEN CITING Published online May 15, 2015; DOI: 10.3171/2014.11.JNS14889.DISCLOSURE Dr. Chang was funded by US National Institutes of Health grants R01-DC012379, R00-NS065120, and DP2-OD00862 and the Ester A. and Joseph Klingenstein Foundation. The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

© AANS, except where prohibited by US copyright law.

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