Plasma taurine as a predictor of poor outcome in patients with mild neurological deficits after aneurysmal subarachnoid hemorrhage

Laboratory investigation

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  • 1 Departments of Neurosurgery and
  • 2 Neurochemistry, National Institute of Neurology and Neurosurgery, Tlalpan, Mexico City, Mexico
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Object

The object of this study was to determine the relationship between plasma taurine and subarachnoid hemorrhage (SAH) outcome.

Methods

Forty patients with SAH and mild neurological deficits were included in this prospective, blinded cohort study. Plasma taurine levels were measured using high-performance liquid chromatography on admission and were correlated with patient outcomes at discharge.

Results

Twenty-five percent of the patients ultimately had a poor outcome. Plasma taurine concentrations at admission were increased (2-fold) in SAH patients with a favorable outcome and were further increased (6-fold) in those who had a poor outcome. Increased taurine levels identified patients who would be discharged with a poor outcome, with sensitivity and specificity values of approximately 80% and 100%, respectively, and positive and negative predictive values of approximately 90%. Delayed cerebral vasospasm showed an OR of 27.9 (95% CI 1.090–714.9) for a poor outcome, whereas an increased taurine concentration had an OR of 105 for a poor outcome (95% CI 8.3–1328.0, p < 0.001).

Conclusions

Increased plasma taurine concentrations on admission predict a poor outcome in SAH.

Abbreviations used in this paper:ACoA = anterior communicating artery; BI = Barthel Index; DCV = delayed cerebral vasospasm; GOS = Glasgow Outcome Scale; HH = Hunt and Hess; PCoA = posterior communicating artery; ROC = receiver operating characteristic; SAH = subarachnoid hemorrhage; TCD = transcranial Doppler; WFNS = World Federation of Neurosurgical Societies.

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Contributor Notes

Address correspondence to: Camilo Ríos, Ph.D., Department of Neurochemistry, National Institute of Neurology and Neurosurgery, Mexico City 14269, Mexico. email: crios@correo.xoc.uam.mx.

Please include this information when citing this paper: published online May 17, 2013; DOI: 10.3171/2013.4.JNS121558.

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