Letters to the Editor: Intraoperative diagnosis

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To The Editor: We read with great interest the recent article by Shioyama et al.3 on a rapid intraoperative characterization of resected gliomas by flow cytometry (Shioyama T, Muragaki Y, Maruyama T, et al: Intraoperative flow cytometry analysis of glioma tissue for rapid determination of tumor presence and its histopathological grade. Clinical article. J Neurosurg 118:1232–1238, June 2013). The authors evaluated within 10 minutes the malignancy index (MI), defined as the ratio of the number of cells with greater than normal DNA content to the total number of cells, of

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Please include this information when citing this paper: published online May 31, 2013; DOI: 10.3171/2013.3.JNS13404.

© AANS, except where prohibited by US copyright law.

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    Left: A case of benign meningioma tissue analyzed by flow cytometry. Ploidy histogram from the patient showing G0/G1 of 87.4%, S-phase of 2.5%, and G2/M of 8.9%. Right: A case of glioblastoma. Ploidy histogram from the patient showing G0/G1 of 29.2%, S-phase of 9.3%, and G2/M of 61.7%.

References

1

Alexiou GATsiouris SVartholomatos GFotakopoulos GPapadopoulos AKyritsis AP: Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptake. Clin Neurol Neurosurg 111:8088112009

2

Alexiou GAVartholomatos GTsiouris SPapadopoulos AKyritsis APPolyzoidis KS: Evaluation of meningioma aggressiveness by (99m)Tc-Tetrofosmin SPECT. Clin Neurol Neurosurg 110:6456482008

3

Shioyama TMuragaki YMaruyama TKomori TIseki H: Intraoperative flow cytometry analysis of glioma tissue for rapid determination of tumor presence and its histopathological grade. Clinical article. J Neurosurg 118:123212382013

1

Chiang MFChang CNChen MFHo YS: Nuclear multiparameter flow cytometric DNA analysis of human brain tumors: correlation of DNA content with tumor histology and clinical behavior. Surg Neurol 50:65721998

2

Coons SWJohnson PC: Regional heterogeneity in the DNA content of human gliomas. Cancer 72:305230601993

3

Garcia RBueno ACastañon SRuiz-Barnes PMaria de Campos JKusak E: Study of the DNA content by flow cytometry and proliferation in 281 brain tumors. Oncology 54:1121171997

4

Muragaki YIseki HMaruyama TTanaka MShinohara CSuzuki T: Information-guided surgical management of gliomas using low-field-strength intraoperative MRI. Acta Neurochir Suppl 109:67722011

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