Radiosurgery for patients with unruptured intracranial arteriovenous malformations

Clinical article

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Object

The appropriate management of unruptured intracranial arteriovenous malformations (AVMs) remains controversial. In the present study, the authors evaluate the radiographic and clinical outcomes of radiosurgery for a large cohort of patients with unruptured AVMs.

Methods

From a prospective database of 1204 cases of AVMs involving patients treated with radiosurgery at their institution, the authors identified 444 patients without evidence of rupture prior to radiosurgery. The patients' mean age was 36.9 years, and 50% were male. The mean AVM nidus volume was 4.2 cm3, 13.5% of the AVMs were in a deep location, and 44.4% were at least Spetzler-Martin Grade III. The median radiosurgical prescription dose was 20 Gy. Univariate and multivariate Cox regression analyses were used to determine risk factors associated with obliteration, postradiosurgery hemorrhage, radiation-induced changes, and postradiosurgery cyst formation. The mean duration of radiological and clinical follow-up was 76 months and 86 months, respectively.

Results

The cumulative AVM obliteration rate was 62%, and the postradiosurgery annual hemorrhage rate was 1.6%. Radiation-induced changes were symptomatic in 13.7% and permanent in 2.0% of patients. The statistically significant independent positive predictors of obliteration were no preradiosurgery embolization (p < 0.001), increased prescription dose (p < 0.001), single draining vein (p < 0.001), radiological presence of radiation-induced changes (p = 0.004), and lower Spetzler-Martin grade (p = 0.016). Increased volume and higher Pittsburgh radiosurgery-based AVM score were predictors of postradiosurgery hemorrhage in the univariate analysis only. Clinical deterioration occurred in 30 patients (6.8%), more commonly in patients with postradiosurgery hemorrhage (p = 0.018).

Conclusions

Radiosurgery afforded a reasonable chance of obliteration of unruptured AVMs with relatively low rates of clinical and radiological complications.

Abbreviations used in this paper:ARUBA = A Randomized Trial of Unruptured Brain Arteriovenous Malformations; AVM = arteriovenous malformation; DSA = digital subtraction angiography; HR = hazard ratio; RIC = radiation-induced change.

Article Information

Address correspondence to: Jason Sheehan, M.D., Ph.D., University of Virginia, Department of Neurological Surgery, P.O. Box 800212, Charlottesville, Virginia 22908. email: jps2f@virginia.edu.

Please include this information when citing this paper: published online March 26, 2013; DOI: 10.3171/2013.2.JNS121239.

© AANS, except where prohibited by US copyright law.

Headings

Figures

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    Composition of patient group.

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    Plot showing imaging (upper) and clinical (lower) follow-up for patients with unruptured AVMs.

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    Plot showing AVM obliteration rate versus time after radiosurgical treatment of unruptured AVMs.

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    Plot showing obliteration rate of unruptured AVMs following radiosurgery differentiated by presence of postradiosurgery hemorrhage. Obliteration was significantly more likely in unruptured AVMs without postradiosurgery hemorrhage than in those with postradiosurgery hemorrhage (p = 0.018).

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