Influence of hemodynamics on recanalization of totally occluded intracranial aneurysms: a patient-specific computational fluid dynamic simulation study

Laboratory investigation

Chuanhui LiBeijing Tiantan Hospital, Beijing Neurosurgical Institute, and

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 M.S.
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Shengzhang WangDepartment of Mechanics and Engineering Science, Fudan University, Shanghai; and

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 Ph.D.
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Jialiang ChenDepartment of Mechanics and Engineering Science, Fudan University, Shanghai; and

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 Ph.D.
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Hongyu YuDepartment of Biomedical Engineering, Capital Medical University, Beijing;

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 Ph.D.
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Ying ZhangBeijing Tiantan Hospital, Beijing Neurosurgical Institute, and

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 M.S.
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Fan JiangKey Laboratory of Cardiovascular Remodeling and Function Research, Medical School and Qilu Hospital, Shandong University, Jinan, Shandong Province, China

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 Ph.D.
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Shiqing MuBeijing Tiantan Hospital, Beijing Neurosurgical Institute, and

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 M.D.
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Haiyun LiDepartment of Biomedical Engineering, Capital Medical University, Beijing;

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 Ph.D.
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Xinjian YangBeijing Tiantan Hospital, Beijing Neurosurgical Institute, and

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 M.D., Ph.D.
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Object

Some totally occluded intracranial aneurysms may recur. The role of hemodynamic mechanisms in this process remains to be elucidated. The authors used computational fluid dynamic analysis and investigated the local hemodynamic characteristics at the aneurysm neck before and after total embolization, attempting to identify hemodynamic risk factors leading to recurrence of totally embolized aneurysms.

Methods

Between May 2008 and June 2010, the authors recruited 17 consecutive patients with totally occluded intracranial aneurysms (7 recanalized and 10 stable lesions). Using patient-specific 3D digital subtraction angiography data, the hemodynamic features before and after embolization were retrospectively characterized.

Results

The overall preembolization blood flow patterns were nearly the same in the recanalized and stable groups, with no significant difference in either the maximum wall shear stress (WSS) (p = 0.914) or the spatially averaged WSS (p = 0.322) at peak systole at the aneurysm neck. After occlusion, the overall flow pattern changed, and the WSS distribution at the treated aneurysm neck differed in the 2 groups. In all of the 7 recanalized cases, both the maximum WSS and spatially averaged WSS at peak systole at the treated aneurysm neck were higher than those at the aneurysm neck before embolization. In contrast, both parameters were decreased in 70%–80% of the stable cases. After embolization, both the maximum WSS (p = 0.021) and spatially averaged WSS (p = 0.041) at peak systole at the treated aneurysm neck were higher in the recanalized group than in the stable group.

Conclusions

Higher WSS at the treated aneurysm neck after total embolization can be an important hemodynamic factor that contributes to aneurysm recurrence after endovascular treatment.

Abbreviations used in this paper:

CFD = computational fluid dynamics; DSA = digital subtraction angiography; SAH = subarachnoid hemorrhage; WSS = wall shear stress.
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