Editorial: Simpson Grade and MIB-1

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The paper by Oya and colleagues2 in the Journal of Neurosurgery is timely and important. These authors from the University of Tokyo have retrospectively, but very carefully, analyzed a series of 240 patients with 248 benign (WHO Grade I) intracranial meningiomas that were resected at the University of Tokyo Hospital between January 1995 and August 2010. The authors included only patients who had undergone radiological follow-up for at least 6 months, and they calculated the 5-year recurrence-free survival (RFS) by Kaplan-Meir analysis and correlated that with the Simpson grade and the MIB-1 labeling index (LI). All

Article Information

Please include this information when citing this paper: published online May 4, 2012; DOI: 10.3171/2012.1.JNS112319.

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Heros RC: Simpson grade and treatment. Editorial J Neurosurg 113:102610282010


Oya SKawai KNakatomi HSaito N: Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas. Clinical article. J Neurosurg [epub ahead of print May 4 2012. DOI: 10.3171/2012.3.JNS111945]


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Vranic APopovic MCör APrestor BPizem J: Mitotic count, brain invasion, and location are independent predictors of recurrence-free survival in primary atypical and malignant meningiomas: a study of 86 patients. Neurosurgery 67:112411322010




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