Letter to the Editor: Glioma spheroids

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Article Information

Please include this information when citing this paper: published online December 2, 2011; DOI: 10.3171/2011.5.JNS11756.

© AANS, except where prohibited by US copyright law.



  • 1

    Etminan NPeters CFicnar JAnlasik SBünemann ESlotty PJ: Modulation of migratory activity and invasiveness of human glioma spheroids following 5-aminolevulinic acid–based photodynamic treatment. Laboratory investigation. J Neurosurg 115:2812882011

  • 2

    Hueng DYLin GJHuang SHLiu LWJu DTChen YW: Inhibition of Nodal suppresses angiogenesis and growth of human gliomas. J Neurooncol 104:21312011

  • 3

    Hueng DYSytwu HKHuang SMChang CMa HI: Isolation and characterization of tumor stem-like cells from human meningiomas. J Neurooncol 104:45532011

  • 4

    Jan HJLee CCShih YLHueng DYMa HILai JH: Osteopontin regulates human glioma cell invasiveness and tumor growth in mice. Neuro Oncol 12:58702010

  • 5

    Lee CCJan HJLai JHMa HIHueng DYLee YC: Nodal promotes growth and invasion in human gliomas. Oncogene 29:311031232010

  • 6

    Ma HIChiou SHHueng DYTai LKHuang PIKao CL: Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects. Laboratory investigation. J Neurosurg 114:6516622011

  • 1

    Au CMLuk SKJackson CJNg HKYow CMTo SS: Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J Photochem Photobiol B 85:921012006

  • 2

    Beck TJKreth FWBeyer WMehrkens JHObermeier AStepp H: Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX. Lasers Surg Med 39:3863932007

  • 3

    Casas ADi Venosa GVanzulli SPerotti CMamome LRodriguez L: Decreased metastatic phenotype in cells resistant to aminolevulinic acid-photodynamic therapy. Cancer Lett 271:3423512008

  • 4

    Chu ESWong TKYow CM: Photodynamic effect in medulloblastoma: downregulation of matrix metalloproteinases and human telomerase reverse transcriptase expressions. Photochem Photobiol Sci 7:76832008

  • 5

    Eljamel MSGoodman CMoseley H: ALA and Photofrin fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial. Lasers Med Sci 23:3613672008

  • 6

    Friedrich JSeidel CEbner RKunz-Schughart LA: Spheroid-based drug screen: considerations and practical approach. Nat Protoc 4:3093242009

  • 7

    Günther HSSchmidt NOPhillips HSKemming DKharbanda SSoriano R: Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene 27:289729092008

  • 8

    Hirschberg HSun CHKrasieva TMadsen SJ: Effects of ALA-mediated photodynamic therapy on the invasiveness of human glioma cells. Lasers Surg Med 38:9399452006

  • 9

    Jiang FChopp MKatakowski MCho KKYang XHochbaum N: Photodynamic therapy with photofrin reduces invasiveness of malignant human glioma cells. Lasers Med Sci 17:2802882002

  • 10

    Lee JKotliarova SKotliarov YLi ASu QDonin NM: Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:3914032006

  • 11

    Stummer WBeck TBeyer WMehrkens JHObermeier AEtminan N: Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report. J Neurooncol 87:1031092008

  • 12

    Sutherland RM: Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240:1771841988

  • 13

    Tsai TJi HTChiang PCChou RHChang WSChen CT: ALA-PDT results in phenotypic changes and decreased cellular invasion in surviving cancer cells. Lasers Surg Med 41:3053152009




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