Clinicopathological factors related to regrowth of vestibular schwannoma after incomplete resection

Clinical article

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Object

The authors retrospectively analyzed various clinicopathological factors to determine which are related to regrowth during a long-term follow-up period in patients who underwent incomplete vestibular schwannoma (VS) resection.

Methods

This study involved 74 patients (25 men and 49 women) in whom a VS was treated surgically via the lateral suboccipital approach, and who had postoperative follow-up periods exceeding 5 years. The mean follow-up was 104.1 months (range 60–241 months), and the mean patient age at surgery was 48.1 years (range 19–75 years). The tumors ranged in size from 0 mm (localized within the internal auditory canal) to 56 mm (28.3 ± 12.2 mm [mean ± SD]).

Results

Gross-total resection (GTR) was performed in 41 (55%) of the 74 patients; subtotal resection ([STR]; 90–99%) in 25 (34%); and partial resection ([PR]; < 90%) in 8 (11%). Regrowth rates in the GTR, STR, and PR groups were 2.4% (1 of 41 cases), 52% (13 of 25), and 62.5% (5 of 8), respectively, and the times to regrowth ranged from 6 to 76 months (median 31.9 months). The regrowth-free survival curves differed significantly between the complete (GTR) and incomplete (STR and PR) resection groups. Eighteen (54.5%) of the 33 patients who underwent incomplete resection showed evidence of regrowth during follow-up. Univariate and multivariate analyses of various factors revealed that both the thickness of the residual tumor, based on MR imaging after surgery, and the MIB-1 index were positively related to residual tumor regrowth. The receiver operating characteristic curves, plotted for both the thickness of the residual tumor and the MIB-1 index, identified the optimal cutoff points for these values as 7.4 mm (sensitivity 83.3%, specificity 86.7%) and 1.6 (sensitivity 83.3%, specificity 66.7%), respectively.

Conclusions

Greater residual tumor thickness, based on MR imaging after the initial surgery, and a higher MIB-1 index are both important factors related to postoperative tumor regrowth in patients who have undergone incomplete VS resection. These patients require frequent neuroimaging investigation during follow-up to assure early detection of tumor regrowth.

Abbreviations used in this paper: GKS = Gamma Knife surgery; GTR = gross-total resection; IAC = internal auditory canal; PR = partial resection; ROC = receiver operating characteristics; STR = subtotal resection; VS = vestibular schwannoma.
Article Information

Contributor Notes

Address correspondence to: Masafumi Fukuda, M.D., Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757 Asahimachi-dori, Niigata-City 951-8585, Japan. email: mfuku529@bri.niigata-u.ac.jp.Please include this information when citing this paper: published online January 7, 2011; DOI: 10.3171/2010.11.JNS101041.

© AANS, except where prohibited by US copyright law.

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